The DNA repair protein ATM as a target in autism spectrum disorder
暂无分享,去创建一个
M. Passafaro | E. Menna | N. Landsberger | F. Antonucci | F. Bifari | M. Sala | M. Matteoli | L. Murru | L. Ponzoni | S. Ferrara | L. Pizzamiglio | G. Desiato | C. Cambria | E. Focchi
[1] Chiara Nicolini,et al. The valproic acid-induced rodent model of autism , 2018, Experimental Neurology.
[2] M. Woodin,et al. Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model , 2018, Proceedings of the National Academy of Sciences.
[3] I. Barajon,et al. Maternal Immune Activation Delays Excitatory-to-Inhibitory Gamma-Aminobutyric Acid Switch in Offspring , 2017, Biological Psychiatry.
[4] Jennifer L. Levy,et al. Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS. , 2017, Cell reports.
[5] M. Passafaro,et al. Pharmacological Modulation of AMPAR Rescues Intellectual Disability-Like Phenotype in Tm4sf2−/y Mice , 2017, Cerebral cortex.
[6] W. Lasoń,et al. The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D. , 2017, The international journal of biochemistry & cell biology.
[7] C. Garlanda,et al. Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects , 2017, eLife.
[8] A. Bird,et al. The Role of Epigenetic Mechanisms in the Regulation of Gene Expression in the Nervous System , 2016, The Journal of Neuroscience.
[9] M. Sur,et al. Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome , 2016, Proceedings of the National Academy of Sciences.
[10] N. Landsberger,et al. Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms. , 2016, Cerebral cortex.
[11] M. Passafaro,et al. New Role of ATM in Controlling GABAergic Tone During Development. , 2016, Cerebral cortex.
[12] F. Antonucci,et al. The Timing of the Excitatory-to-Inhibitory GABA Switch Is Regulated by the Oxytocin Receptor via KCC2 , 2016, Cell reports.
[13] Wei Li,et al. Excitatory synapses are stronger in the hippocampus of Rett syndrome mice due to altered synaptic trafficking of AMPA-type glutamate receptors , 2016, Proceedings of the National Academy of Sciences.
[14] F. Gage,et al. KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome , 2016, Proceedings of the National Academy of Sciences.
[15] B. Burrell,et al. Differential effects of GABA in modulating nociceptive vs. non-nociceptive synapses , 2015, Neuroscience.
[16] Andreas R. Pfenning,et al. Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes , 2015, Cell.
[17] R. J. Mather,et al. Selective Inhibition of KCC2 Leads to Hyperexcitability and Epileptiform Discharges in Hippocampal Slices and In Vivo , 2015, The Journal of Neuroscience.
[18] A. Contestabile,et al. Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome , 2015, Nature Medicine.
[19] R. Corvò,et al. Pharmacokinetics, pharmacodynamics and efficacy on pediatric tumors of the glioma radiosensitizer KU60019 , 2015, International journal of cancer.
[20] N. Brandon,et al. KCC2 activity is critical in limiting the onset and severity of status epilepticus , 2015, Proceedings of the National Academy of Sciences.
[21] S. Hormuzdi,et al. Neuronal chloride transport tuning , 2015, The Lancet.
[22] Wei Li,et al. Excitation/inhibition imbalance and impaired synaptic inhibition in hippocampal area CA3 of Mecp2 knockout mice , 2015, Hippocampus.
[23] H. Vinters,et al. Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington’s disease , 2014, Science Translational Medicine.
[24] X. Tian,et al. The suppression of epileptiform discharges in cultured hippocampal neurons is regulated via alterations in full‐length tropomyosin‐related kinase type B receptors signalling activity , 2014, The European journal of neuroscience.
[25] M. Mottolese,et al. ATM kinase sustains HER2 tumorigenicity in breast cancer , 2014, Nature Communications.
[26] P. Awadalla,et al. Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy , 2014, EMBO reports.
[27] I. Scheffer,et al. A variant of KCC2 from patients with febrile seizures impairs neuronal Cl− extrusion and dendritic spine formation , 2014, EMBO reports.
[28] J. Schuurs-Hoeijmakers,et al. TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function , 2014, Nature Genetics.
[29] M. Milanese,et al. Fluoxetine in adulthood normalizes GABA release and rescues hippocampal synaptic plasticity and spatial memory in a mouse model of Down Syndrome , 2014, Neurobiology of Disease.
[30] Y. Lee,et al. Genome-wide pathway analysis in attention-deficit/hyperactivity disorder , 2014, Neurological Sciences.
[31] Amene Shahrokhi,et al. Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring , 2014, Science.
[32] D. Reutens,et al. Inhibition of histone deacetylase in utero causes sociability deficits in postnatal mice , 2013, Behavioural Brain Research.
[33] S. Gau,et al. Runs of Homozygosity Associated with Speech Delay in Autism in a Taiwanese Han Population: Evidence for the Recessive Model , 2013, PloS one.
[34] S. Duarte,et al. Abnormal Expression of Cerebrospinal Fluid Cation Chloride Cotransporters in Patients with Rett Syndrome , 2013, PloS one.
[35] N. Curtin,et al. Preclinical Evaluation of a Novel ATM Inhibitor, KU59403, In Vitro and In Vivo in p53 Functional and Dysfunctional Models of Human Cancer , 2013, Molecular Cancer Therapeutics.
[36] Tuoen Liu,et al. Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential. , 2012, Pharmacology & therapeutics.
[37] J. Sarkaria,et al. ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells , 2012, Journal of Neuro-Oncology.
[38] Martin K. Schwarz,et al. Evoked Axonal Oxytocin Release in the Central Amygdala Attenuates Fear Response , 2012, Neuron.
[39] A. Alpár,et al. Cracking Down on Inhibition: Selective Removal of GABAergic Interneurons from Hippocampal Networks , 2012, The Journal of Neuroscience.
[40] David A. Lewis,et al. Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia , 2012, Trends in Neurosciences.
[41] M. Jäättelä,et al. Identification of Small Molecule Inhibitors of Phosphatidylinositol 3-Kinase and Autophagy* , 2011, The Journal of Biological Chemistry.
[42] Lief E. Fenno,et al. Neocortical excitation/inhibition balance in information processing and social dysfunction , 2011, Nature.
[43] M. Greenberg,et al. Neuronal activity-regulated gene transcription in synapse development and cognitive function. , 2011, Cold Spring Harbor perspectives in biology.
[44] T. Rubino,et al. Pharmacologic Rescue of Impaired Cognitive Flexibility, Social Deficits, Increased Aggression, and Seizure Susceptibility in Oxytocin Receptor Null Mice: A Neurobehavioral Model of Autism , 2011, Biological Psychiatry.
[45] C. Rivera,et al. Early Growth Response 4 Mediates BDNF Induction of Potassium Chloride Cotransporter 2 Transcription , 2011, The Journal of Neuroscience.
[46] M. Lavin,et al. ATM Activation by Oxidative Stress , 2010, Science.
[47] D. deCatanzaro,et al. Behavioral and molecular changes in the mouse in response to prenatal exposure to the anti-epileptic drug valproic acid , 2010, Neuroscience.
[48] C. Lord,et al. Behavioural phenotyping assays for mouse models of autism , 2010, Nature Reviews Neuroscience.
[49] Da-Qing Yang,et al. The ATM Inhibitor KU-55933 Suppresses Cell Proliferation and Induces Apoptosis by Blocking Akt In Cancer Cells with Overactivated Akt , 2010, Molecular Cancer Therapeutics.
[50] K. Herrup,et al. Cytoplasmic ATM in Neurons Modulates Synaptic Function , 2009, Current Biology.
[51] I. Takasaki,et al. Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions , 2009, Neuroscience Research.
[52] Philippe Séguéla,et al. Downregulation of tonic GABAergic inhibition in a mouse model of fragile X syndrome. , 2009, Cerebral cortex.
[53] T. Hei,et al. Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells. , 2009, Cancer research.
[54] B. Price,et al. Activation of the Kinase Activity of ATM by Retinoic Acid Is Required for CREB-dependent Differentiation of Neuroblastoma Cells* , 2007, Journal of Biological Chemistry.
[55] C. Rivera,et al. Upregulation of the Neuron-Specific K+/Cl− Cotransporter Expression by Transcription Factor Early Growth Response 4 , 2006, The Journal of Neuroscience.
[56] T. Timmusk,et al. Neuronal K+/Cl– co‐transporter (KCC2) transgenes lacking neurone restrictive silencer element recapitulate CNS neurone‐specific expression and developmental up‐regulation of endogenous KCC2 gene , 2005, Journal of neurochemistry.
[57] Y. Ben-Ari,et al. Early expression of KCC2 in rat hippocampal cultures augments expression of functional GABA synapses , 2005, The Journal of physiology.
[58] A. Addington,et al. GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD67), is associated with childhood-onset schizophrenia and cortical gray matter volume loss , 2005, Molecular Psychiatry.
[59] Pat Levitt,et al. Regulation of neocortical interneuron development and the implications for neurodevelopmental disorders , 2004, Trends in Neurosciences.
[60] N. Logothetis. The Underpinnings of the BOLD Functional Magnetic Resonance Imaging Signal , 2003, The Journal of Neuroscience.
[61] Y. Ben-Ari. Excitatory actions of gaba during development: the nature of the nurture , 2002, Nature Reviews Neuroscience.
[62] Arnold R. Kriegstein,et al. Is there more to gaba than synaptic inhibition? , 2002, Nature Reviews Neuroscience.
[63] A. Barzilai,et al. Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice. , 2001, Cancer research.
[64] A. Kriegstein,et al. An excitatory GABAergic plexus in developing neocortical layer 1. , 2000, Journal of neurophysiology.
[65] F. Alt,et al. Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[66] Yogesh K. Dwivedi,et al. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[67] Xavier Leinekugel,et al. Ca2+ Oscillations Mediated by the Synergistic Excitatory Actions of GABAA and NMDA Receptors in the Neonatal Hippocampus , 1997, Neuron.
[68] A. Kriegstein,et al. Excitatory GABA Responses in Embryonic and Neonatal Cortical Slices Demonstrated by Gramicidin Perforated-Patch Recordings and Calcium Imaging , 1996, The Journal of Neuroscience.
[69] P. Rodier,et al. Embryological origin for autism: Developmental anomalies of the cranial nerve motor nuclei , 1996, The Journal of comparative neurology.
[70] S. Akbarian,et al. GABAA receptor subunit gene expression in human prefrontal cortex: comparison of schizophrenics and controls. , 1995, Cerebral cortex.
[71] S. Sombati,et al. Recurrent spontaneous seizure activity in hippocampal neuronal networks in culture. , 1995, Journal of neurophysiology.
[72] K. Kuriyama,et al. GABAA receptor stimulation enhances NMDA-induced Ca2+ influx in mouse cerebral cortical neurons in primary culture. , 1994, Brain research. Molecular brain research.
[73] M. Rudnicki,et al. Simplified mammalian DNA isolation procedure. , 1991, Nucleic acids research.
[74] Ryszard Przewłocki,et al. Behavioral Alterations in Rats Prenatally Exposed to Valproic Acid: Animal Model of Autism , 2005, Neuropsychopharmacology.
[75] I Khalilov,et al. GABA is the principal fast-acting excitatory transmitter in the neonatal brain. , 1999, Advances in neurology.
[76] R. Darnell,et al. ATM binds to beta-adaptin in cytoplasmic vesicles. , 1998, Proceedings of the National Academy of Sciences of the United States of America.