Polyurethane microporous membranes as pericardial substitutes

Pericardial substitutes were prepared from stable and degradable segmented polyurethanes and/or polyurethane/polyhydroxybutyrate composites.Polyurethane membranes implanted as pericardial substitute in the rabbit, did not activate adhesion and epicardial reaction over 3 months.Polyurethane/polyhydroxybutyrate membranes induced minimal adhesion or epicardial reaction, yet stimulated the growth of epithelium on the polymeric substrate and reduced the incidence of infection.

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