Electrophysiological studies of hippocampal connections and excitability.

Abstract 1. 1. An electrophysiological study of the afferent and efferent pathways of the hippocampus has been made. 2. 2. The excitability of the hippocampus has been studied before and after isolation from the rest of the brain. 3. 3. Evidence for afferent projections to the hippocampus through the fornix has been adduced. 4. 4. Evidence that the dentate gyrus may present and intermediary relay station is advanced. 5. 5. Evidence is presented for connections between the hippocampus and various cortical and subcortical areas, including limbic cortex, amygdala, diecephalic areas and the midbrain tegmentum. 6. 6. The physiological role of the hippocampus and its significance in seizure discharge are discussed.

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