A comparison of the management of potentially malignant oral mucosal lesions by oral medicine practitioners and oral & maxillofacial surgeons in the UK.

This study describes the results of a survey undertaken to assess the management of potentially malignant oral mucosal lesions by oral medicine practitioners and compares their approach with that of oral & maxillofacial surgeons that we have previously described. Significant differences were noted between the two groups in the use of photography to document the lesions and in the use of certain special investigations, which included measurement of serum iron, serum ferritin, serum Vit B12, red cell folate and candidal isolation. The groups also varied in the perceived importance of the age of the patient and anatomical site of the lesion when deciding on the need for further biopsy. There was also significant variation in the use of certain treatment modalities, including excising non-dysplastic and severely dysplastic/carcinoma in-situ lesions and eliminating trauma when treating mild/moderately dysplastic and severely dysplastic/carcinoma in-situ lesions. Significant differences in the frequency and duration of follow-up were noted for non-dysplastic lesions. Finally, the two groups differed significantly when asked to rank the perceived importance of certain factors (the histopathology of the most recent biopsy and the anatomical site of the lesion) when deciding the need to follow-up. Possible reasons for the variation are discussed.

[1]  P. Johnston,et al.  Paraffin-embedded tissue as a source of RNA for gene expression analysis in oral malignancy. , 2008, Oral diseases.

[2]  C. la Vecchia,et al.  Epidemiology and prevention of oral cancer. , 1997, Oral oncology.

[3]  S. Franceschi,et al.  Screening for cancer of the head and neck: if not now, when? , 1997, Oral oncology.

[4]  K. Schepman,et al.  Oral leukoplakia: a clinicopathological review. , 1997, Oral oncology.

[5]  C. Scully,et al.  Oral leukoplakias: to treat or not? , 1997, Oral oncology.

[6]  J G Cowpe,et al.  Oral exfoliative cytology: review of methods of assessment. , 1997, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[7]  C. Scully,et al.  Genetic aberrations in squamous cell carcinoma of the head and neck (SCCHN), with reference to oral carcinoma (review). , 1997, International journal of oncology.

[8]  N. Johnson,et al.  Sensitivity and specificity of OraScan (R) toluidine blue mouthrinse in the detection of oral cancer and precancer. , 1996, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[9]  N. Johnson,et al.  Management of potentially malignant oral mucosal lesions by consultant UK oral and maxillofacial surgeons. , 1996, The British journal of oral & maxillofacial surgery.

[10]  T. Axéll,et al.  Oral white lesions with special reference to precancerous and tobacco- related lesions: conclusions of an international symposium held in Uppsala, Sweden, May 18-21 1994. International Collaborative Group on Oral White Lesions. , 1996, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[11]  N. Johnson,et al.  Hereditary and environmental risk factors; clinical and laboratory risk matters for head and neck, especially oral, cancer and precancer. , 1996, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[12]  J. Langdon,et al.  Oral cancer: a serious and growing problem. , 1995, Annals of the Royal College of Surgeons of England.

[13]  E. Eisenberg,et al.  Intraexaminer and interexaminer reliability in the diagnosis of oral epithelial dysplasia. , 1995, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[14]  A. Karabulut,et al.  Observer variability in the histologic assessment of oral premalignant lesions. , 1995, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[15]  H Lumerman,et al.  Oral epithelial dysplasia and the development of invasive squamous cell carcinoma. , 1995, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[16]  C. Scully Oral precancer: preventive and medical approaches to management. , 1995, European journal of cancer. Part B, Oral oncology.

[17]  J. Epstein,et al.  Topical bleomycin treatment of oral leukoplakia: A randomized double‐blind clinical trial , 1994, Head & neck.

[18]  P. Robinson,et al.  Expression of human cytokeratin 14 in normal, premalignant and malignant oral tissue following isolation by plaque differential hybridisation. , 1994, European journal of cancer. Part B, Oral oncology.

[19]  C. Scully,et al.  Tissue markers of potentially malignant human oral epithelial lesions. , 1993, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[20]  Lamey Pj Management options in potentially malignant and malignant oral epithelial lesions. , 1993 .

[21]  P. Speight,et al.  The natural history and pathology of oral cancer and precancer. , 1993, Community dental health.

[22]  C. Scully Clinical diagnostic methods for the detection of premalignant and early malignant oral lesions. , 1993, Community dental health.

[23]  N. Johnson,et al.  Epidemiology and aetiology of oral cancer in the United Kingdom. , 1993, Community dental health.

[24]  J. M. Hirsch,et al.  Measures of dental beliefs and attitudes: their relationships with measures of fear. , 1993, Community dental health.

[25]  N. Johnson,et al.  Potentially malignant lesions and conditions of the mouth and oropharynx: natural history--cellular and molecular markers of risk. , 1993, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[26]  F. Kee,et al.  Trends in the relative frequency of histologically diagnosed epithelial dysplasia and intra-oral carcinoma in Northern Ireland, 1975-1989 , 1992, British Dental Journal.

[27]  F. Kee,et al.  Trends in the incidence of histologically diagnosed intra-oral squamous cell carcinoma in Northern Ireland, 1975-89 , 1992, British Dental Journal.

[28]  G. Margarino,et al.  Progressive 13-cis-retinoic acid dosage in the treatment of oral leukoplakia. , 1992, European journal of cancer. Part B, Oral oncology.

[29]  R. Cancedda,et al.  In vitro effects of beta-carotene on human oral keratinocytes from precancerous lesions and squamous carcinoma. , 1991, Anti-cancer drugs.

[30]  R. Sampliner,et al.  The effects of 13‐cis‐retinoic acid and beta‐carotene on cellular immunity in humans , 1991, Cancer.

[31]  M. Nair,et al.  Remission of oral precancerous lesions of tobacco/areca nut chewers following administration of beta-carotene or vitamin A, and maintenance of the protective effect. , 1991, Cancer detection and prevention.

[32]  P. Krogh The role of yeasts in oral cancer by means of endogenous nitrosation. , 1990, Acta odontologica Scandinavica.

[33]  Zarbo Rj,et al.  Dysplasia, in situ carcinoma, and progression to invasive squamous cell carcinoma of the upper aerodigestive tract. , 1989 .

[34]  P. Stell,et al.  CANCER OF THE HEAD AND NECK: ARE WE DOING ANY BETTER? , 1985, The Lancet.

[35]  A. Burkhardt Advanced methods in the evaluation of premalignant lesions and carcinomas of the oral mucosa. , 1985, Journal of oral pathology.

[36]  J. Reibel,et al.  Subjectivity in evaluating oral epithelial dysplasia, carcinoma in situ and initial carcinoma. , 1985, Journal of oral pathology.

[37]  S. Silverman,et al.  Proliferative verrucous leukoplakia: A long-term study of thirty patients , 1985 .

[38]  D. Macdonald,et al.  Iron and the Oral Epithelium: A Review , 1984, Journal of the Royal Society of Medicine.

[39]  M. Gorsky,et al.  Oral leukoplakia and malignant transformation. A follow‐up study of 257 patients , 1984, Cancer.

[40]  D. Macdonald,et al.  Cell kinetics of hamster ventral tongue epithelium in iron deficiency. , 1984, Archives of oral biology.

[41]  N. Johnson,et al.  Prognostic significance of STNMp and velocity of tumor growth in oral cancer , 1982, Cancer.

[42]  F. Mehta,et al.  A follow-up study of sixty-one oral dysplastic precancerous lesions in Indian villagers. , 1977, Oral surgery, oral medicine, and oral pathology.

[43]  J. Bánóczy,et al.  Occurrence of epithelial dysplasia in oral leukoplakia. Analysis and follow-up study of 12 cases. , 1976, Oral surgery, oral medicine, and oral pathology.

[44]  W. G. Shafer,et al.  Leukoplakia revisited. A clinicopathologic study 3256 oral leukoplakias , 1975, Cancer.

[45]  H. Mincer,et al.  Observations on the clinical characteristics of oral lesions showing histologic epithelial dysplasia. , 1972, Oral surgery, oral medicine, and oral pathology.

[46]  D. R. Paterson A Clinical Type of Dysphagia , 1919, The Journal of Laryngology & Otology.