The phosphoinositide 3‐kinase/Akt pathway is activated by daunorubicin in human acute myeloid leukemia cell lines

[1]  Philip R. Cohen,et al.  The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2. , 1998, The Biochemical journal.

[2]  J. Downward Mechanisms and consequences of activation of protein kinase B/Akt. , 1998, Current opinion in cell biology.

[3]  N. Hay,et al.  Akt, a Target of Phosphatidylinositol 3-Kinase, Inhibits Apoptosis in a Differentiating Neuronal Cell Line , 1998, Molecular and Cellular Biology.

[4]  T. Tsukahara,et al.  Wortmannin enhances activation of CPP32 (Caspase-3) induced by TNF or anti-Fas , 1998, Cell Death and Differentiation.

[5]  F. McCormick,et al.  Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. , 1998, Science.

[6]  D. Cantrell,et al.  Protection of CD95‐mediated apoptosis by activation of phosphatidylinositide 3‐kinase and protein kinase B , 1998, European journal of immunology.

[7]  P. Cohen,et al.  Role of Translocation in the Activation and Function of Protein Kinase B* , 1997, The Journal of Biological Chemistry.

[8]  G. Laurent,et al.  The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin. , 1997, Cancer research.

[9]  L. Peso,et al.  Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. , 1997, Science.

[10]  A. Kowalski-Chauvel,et al.  Tyrosine phosphorylation of insulin receptor substrate-1 and activation of the PI-3-kinase pathway by glycine-extended gastrin precursors. , 1997, Biochemical and biophysical research communications.

[11]  J. Jaffrezou,et al.  Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[12]  A. Toker,et al.  Signalling through the lipid products of phosphoinositide-3-OH kinase , 1997, Nature.

[13]  R. Salgia,et al.  Differential Signaling after β1 Integrin Ligation Is Mediated Through Binding of CRKL to p120 CBL and p110 HEF1 * , 1997, The Journal of Biological Chemistry.

[14]  G. Laurent,et al.  Influence of Bcl-2 overexpression on the ceramide pathway in daunorubicin-induced apoptosis of leukemic cells , 1997, Oncogene.

[15]  P. Tsichlis,et al.  Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[16]  R. Salgia,et al.  Steel Factor Induces Tyrosine Phosphorylation of CRKL and Binding of CRKL to a Complex Containing c-Kit, Phosphatidylinositol 3-Kinase, and p120CBL* , 1997, The Journal of Biological Chemistry.

[17]  N. Hay,et al.  The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. , 1997, Genes & development.

[18]  A. Klippel,et al.  Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt , 1997, Molecular and cellular biology.

[19]  David R. Kaplan,et al.  Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt , 1997, Science.

[20]  Y. Hannun Functions of Ceramide in Coordinating Cellular Responses to Stress , 1996, Science.

[21]  P. Cossart,et al.  A Role for Phosphoinositide 3-Kinase in Bacterial Invasion , 1996, Science.

[22]  D. Rodríguez‐Puyol,et al.  Oxidative stress induces tyrosine phosphorylation of PDGF α-and β-receptors and pp60c−src in mesangial cells , 1996 .

[23]  J. Downward,et al.  Activation of phosphoinositide 3‐kinase by interaction with Ras and by point mutation. , 1996, The EMBO journal.

[24]  J. Jaffrezou,et al.  Daunorubicin‐induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis. , 1996, The EMBO journal.

[25]  G. Laurent,et al.  Daunorubicin-induced internucleosomal DNA fragmentation in acute myeloid cell lines. , 1996, Leukemia.

[26]  B. Price,et al.  The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage. , 1996, Cancer research.

[27]  K. Teng,et al.  p21ras as a Common Signaling Target of Reactive Free Radicals and Cellular Redox Stress (*) , 1995, The Journal of Biological Chemistry.

[28]  W. El-Deiry,et al.  BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: a mechanism of resistance to multiple anticancer agents. , 1995, Blood.

[29]  G. Zon,et al.  Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells. , 1995, Blood.

[30]  B. Payrastre,et al.  Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase , 1995, The Journal of cell biology.

[31]  G. Cooper,et al.  Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. , 1995, Science.

[32]  S. Grant,et al.  Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells. , 1994, The Journal of biological chemistry.

[33]  S. Isonishi,et al.  Doxorubicin enhances transient expression of p-glycoprotein and modulates activity and isoform expression of protein-kinase-C in ah66 rat hepatoma-cells. , 1994, International journal of oncology.

[34]  J. Exton,et al.  Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. , 1993, The Journal of biological chemistry.

[35]  P. Riesz,et al.  Free radicals induced by adriamycin-sensitive and adriamycin-resistant cells: a spin-trapping study. , 1989, Biochemistry.