Cox-2 expression, PGE(2) and cytokines production are inhibited by endogenously synthesized n-3 PUFAs in inflamed colon of fat-1 mice.

[1]  R. DuBois,et al.  Eicosanoids and cancer , 2010, Nature Reviews Cancer.

[2]  Takao Shimizu,et al.  Lipid mediators in health and disease: enzymes and receptors as therapeutic targets for the regulation of immunity and inflammation. , 2009, Annual review of pharmacology and toxicology.

[3]  J. Marsh,et al.  Purification and characterisation of relevant natural and recombinant apple allergens. , 2008, Molecular nutrition & food research.

[4]  R. DuBois,et al.  Pro-inflammatory prostaglandins and progression of colorectal cancer. , 2008, Cancer letters.

[5]  P. Calder.  Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases. , 2008, Molecular nutrition & food research.

[6]  K. Isse,et al.  Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acids. , 2008, Cancer research.

[7]  J. Kang.  Fat-1 transgenic mice: a new model for omega-3 research. , 2007, Prostaglandins, leukotrienes, and essential fatty acids.

[8]  R. Tuma,et al.  The Proinflammatory Effect of Prostaglandin E2 in Experimental Inflammatory Bowel Disease Is Mediated through the IL-23→IL-17 Axis1 , 2007, The Journal of Immunology.

[9]  B. Gasztonyi,et al.  Association of n-3 and n-6 long-chain polyunsaturated fatty acids in plasma lipid classes with inflammatory bowel diseases , 2007, British Journal of Nutrition.

[10]  R. Leicester,et al.  Eicosapentaenoic acid (EPA) reduces crypt cell proliferation and increases apoptosis in normal colonic mucosa in subjects with a history of colorectal adenomas , 2007, International Journal of Colorectal Disease.

[11]  L. Wheeler,et al.  The Prevention of Colitis by E Prostanoid Receptor 4 Agonist through Enhancement of Epithelium Survival and Regeneration , 2007, Journal of Pharmacology and Experimental Therapeutics.

[12]  Robert S Chapkin,et al.  Colon cancer, fatty acids and anti-inflammatory compounds , 2007, Current opinion in gastroenterology.

[13]  R. Xu,et al.  Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine. , 2006, Gastroenterology.

[14]  K. Weylandt,et al.  Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[15]  Agneta Karlsson,et al.  Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation. , 2005, American journal of physiology. Gastrointestinal and liver physiology.

[16]  Y. Denkins,et al.  Role of omega-3 polyunsaturated fatty acids on cyclooxygenase-2 metabolism in brain-metastatic melanoma. , 2005, Journal of lipid research.

[17]  M. Comalada,et al.  Biochemical and Molecular Actions of Nutrients Dietary Olive Oil Supplemented with Fish Oil , Rich in EPA and DHA ( n-3 ) Polyunsaturated Fatty Acids , Attenuates Colonic Inflammation in Rats with DSS-Induced Colitis 1 , 2005 .

[18]  P. Calder.  Polyunsaturated fatty acids and inflammation. , 2005, Biochemical Society transactions.

[19]  J. Kang,et al.  A simplified method for analysis of polyunsaturated fatty acids , 2005, BMC Biochemistry.

[20]  Claude Pichard,et al.  n-3 polyunsaturated fatty acids and colon cancer prevention. , 2004, Clinical nutrition.

[21]  J. Kang,et al.  Transgenic mice: Fat-1 mice convert n-6 to n-3 fatty acids , 2004, Nature.

[22]  N. Patel,et al.  Rosiglitazone and 15‐deoxy‐Δ12,14‐prostaglandin J2, ligands of the peroxisome proliferator‐activated receptor‐γ (PPAR‐γ), reduce ischaemia/reperfusion injury of the gut , 2003 .

[23]  D. Hwang,et al.  Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. , 2003, Journal of lipid research.

[24]  S. Narumiya,et al.  The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. , 2002, The Journal of clinical investigation.

[25]  L. Kopelovich,et al.  A Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice. , 2001, Carcinogenesis.

[26]  M. Bertagnolli,et al.  Progressive Changes in Adherens Junction Structure during Intestinal Adenoma Formation in Apc Mutant Mice* , 2001, The Journal of Biological Chemistry.

[27]  William L. Smith,et al.  Structure of Eicosapentaenoic and Linoleic Acids in the Cyclooxygenase Site of Prostaglandin Endoperoxide H Synthase-1* , 2001, The Journal of Biological Chemistry.

[28]  Charles N. Serhan,et al.  Lipid mediator class switching during acute inflammation: signals in resolution , 2001, Nature Immunology.

[29]  Zhihong Chen,et al.  Adenoviral gene transfer of Caenorhabditis elegans n−3 fatty acid desaturase optimizes fatty acid composition in mammalian cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[30]  H. Tsuda,et al.  Inhibitory effects of oleic and docosahexaenoic acids on lung metastasis by colon‐carcinoma‐26 cells are associated with reduced matrix metalloproteinase‐2 and ‐9 activities , 1997, International journal of cancer.

[31]  C. Rao,et al.  Modulating effect of amount and types of dietary fat on colonic mucosal phospholipase A2, phosphatidylinositol-specific phospholipase C activities, and cyclooxygenase metabolite formation during different stages of colon tumor promotion in male F344 rats. , 1996, Cancer research.

[32]  H. Cooper,et al.  Clinicopathologic study of dextran sulfate sodium experimental murine colitis. , 1993, Laboratory investigation; a journal of technical methods and pathology.

[33]  T. Ohkusa,et al.  A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice , 1990 .

[34]  J. Lupton,et al.  Immunomodulatory effects of (n-3) fatty acids: putative link to inflammation and colon cancer. , 2007, The Journal of nutrition.

[35]  V. Chajès,et al.  Omega-6/omega-3 polyunsaturated fatty acid ratio and cancer. , 2003, World review of nutrition and dietetics.