Multiple ras functions can contribute to mammalian cell transformation

[1]  S. Fields,et al.  Analyzing protein-protein interactions using two-hybrid system. , 1995, Methods in enzymology.

[2]  G L Johnson,et al.  Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. , 1994, Science.

[3]  M. Wigler,et al.  Cooperative interaction of S. pombe proteins required for mating and morphogenesis , 1994, Cell.

[4]  M. Karin,et al.  c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases , 1994, Molecular and cellular biology.

[5]  F. McCormick,et al.  Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation. , 1994, Science.

[6]  G. Johnson,et al.  Ras-dependent growth factor regulation of MEK kinase in PC12 cells. , 1994, Science.

[7]  R. Hipskind,et al.  Transient activation of RAF-1, MEK, and ERK2 coincides kinetically with ternary complex factor phosphorylation and immediate-early gene promoter activity in vivo , 1994, Molecular and cellular biology.

[8]  Michael J. Fry,et al.  Phosphatidylinositol-3-OH kinase direct target of Ras , 1994, Nature.

[9]  M. Wigler,et al.  Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[10]  M. Shirouzu,et al.  Mutations that abolish the ability of Ha-Ras to associate with Raf-1. , 1994, Oncogene.

[11]  M. Gilman,et al.  Dual modes of control of c-fos mRNA induction by intracellular calcium in T cells , 1994, Molecular and cellular biology.

[12]  D. Brenner,et al.  Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[13]  C. Marshall,et al.  Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells , 1994, Cell.

[14]  A. Porras,et al.  Dissociation between activation of Raf-1 kinase and the 42-kDa mitogen-activated protein kinase/90-kDa S6 kinase (MAPK/RSK) cascade in the insulin/Ras pathway of adipocytic differentiation of 3T3 L1 cells. , 1994, The Journal of biological chemistry.

[15]  M. Karin,et al.  JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain , 1994, Cell.

[16]  J Downward,et al.  Interaction of Ras and Raf in intact mammalian cells upon extracellular stimulation. , 1994, The Journal of biological chemistry.

[17]  J. Bishop,et al.  Association of pRas and pRaf-1 in a complex correlates with activation of a signal transduction pathway , 1993, Current Biology.

[18]  M. Karin,et al.  Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. , 1993, Genes & development.

[19]  F. McCormick,et al.  Reconstitution of the Raf-1—MEK—ERK Signal Transduction Pathway In Vitro , 1993, Molecular and cellular biology.

[20]  M. Nakafuku,et al.  GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[21]  S. Aaronson,et al.  H-ras and raf-1 cooperate in transformation of NIH3T3 fibroblasts. , 1993, Oncogene.

[22]  P. Parker,et al.  Activity of both Raf and Ras is necessary for activation of transcription of the human T cell receptor beta gene by protein kinase C, Ras plays multiple roles. , 1993, The Journal of biological chemistry.

[23]  P. Warne,et al.  Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro , 1993, Nature.

[24]  S. Elledge,et al.  Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1 , 1993, Nature.

[25]  Jonathan A. Cooper,et al.  Mammalian Ras interacts directly with the serine/threonine kinase raf , 1993, Cell.

[26]  J. Pessin,et al.  Phosphatidylinositol 3-kinase functions upstream of Ras and Raf in mediating insulin stimulation of c-fos transcription. , 1993, The Journal of biological chemistry.

[27]  M. Wigler,et al.  Complex formation between RAS and RAF and other protein kinases. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[28]  M. Weber,et al.  Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase. , 1993, Science.

[29]  G. D’Arcangelo,et al.  A branched signaling pathway for nerve growth factor is revealed by Src-, Ras-, and Raf-mediated gene inductions , 1993, Molecular and cellular biology.

[30]  F. McCormick,et al.  Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target. , 1993, The Journal of biological chemistry.

[31]  R. Treisman,et al.  The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain , 1993, Cell.

[32]  Richard Treisman,et al.  Functional analysis of a growth factor-responsive transcription factor complex , 1993, Cell.

[33]  C. Lange-Carter,et al.  A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf , 1993, Science.

[34]  K. Kaibuchi,et al.  A protein factor for ras p21-dependent activation of mitogen-activated protein (MAP) kinase through MAP kinase kinase. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[35]  P. Cohen,et al.  Activation of the MAP kinase pathway by the protein kinase raf , 1992, Cell.

[36]  M. Wigler,et al.  Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[37]  U. Rapp,et al.  Evidence that Ha-Ras mediates two distinguishable intracellular signals activated by v-Src. , 1992, The Journal of biological chemistry.

[38]  T. Haystead,et al.  Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro. , 1992, Science.

[39]  David L. Brautigan,et al.  Raf-1 activates MAP kinase-kinase , 1992, Nature.

[40]  E. Lagendijk,et al.  Characterization of the yeast BMH1 gene encoding a putative protein homologous to mammalian protein kinase II activators and protein kinase C inhibitors , 1992, FEBS letters.

[41]  X P Zhang,et al.  Random mutagenesis of gene-sized DNA molecules by use of PCR with Taq DNA polymerase. , 1991, Nucleic acids research.

[42]  M. Wigler,et al.  byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype , 1991, Molecular and cellular biology.

[43]  W. Kolch,et al.  Raf-1 protein kinase is required for growth of induced NIH/3T3 cells , 1991, Nature.

[44]  F. McCormick,et al.  Regulators and effectors of ras proteins. , 1991, Annual review of cell biology.

[45]  Morrison Dk,et al.  The Raf-1 kinase as a transducer of mitogenic signals. , 1990 .

[46]  G. Cooper,et al.  Effect of a dominant inhibitory Ha-ras mutation on mitogenic signal transduction in NIH 3T3 cells , 1990, Molecular and cellular biology.

[47]  D. Morrison,et al.  The Raf-1 kinase as a transducer of mitogenic signals. , 1990, Cancer cells.

[48]  M. Wigler,et al.  Genetic analysis of mammalian GAP expressed in yeast , 1989, Cell.

[49]  S. Fields,et al.  A novel genetic system to detect protein–protein interactions , 1989, Nature.

[50]  M. Wigler,et al.  Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae , 1989, Molecular and cellular biology.

[51]  M. Wigler,et al.  Studies of RAS function in the yeast Saccharomyces cerevisiae. , 1988, Cold Spring Harbor symposia on quantitative biology.

[52]  M. Barbacid.  ras genes. , 1987, Annual review of biochemistry.

[53]  D. Beach,et al.  Involvement of ras in sexual differentiation but not in growth control in fission yeast , 1986, The EMBO journal.

[54]  Mark R. Smith,et al.  Requirement for c-ras proteins during viral oncogene transformation , 1986, Nature.

[55]  P. Seeburg,et al.  The complete coding sequence of the human raf oncogene and the corresponding structure of the c-raf-1 gene. , 1986, Nucleic acids research.

[56]  M. Wigler,et al.  Functional homology of mammalian and yeast RAS genes , 1985, Cell.

[57]  J. Sambrook,et al.  Molecular Cloning: A Laboratory Manual , 2001 .

[58]  M. Wigler,et al.  DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[59]  G. Fink,et al.  Methods in yeast genetics , 1979 .