Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein

[1]  Chuong B. Do,et al.  Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease , 2014, Nature Genetics.

[2]  M. Farrer,et al.  EIF4G1 gene mutations are not a common cause of Parkinson's disease in the Japanese population. , 2014, Parkinsonism & related disorders.

[3]  G. Petsko,et al.  Pharmacological chaperones stabilize retromer to limit APP processing. , 2014, Nature chemical biology.

[4]  M. Kumar,et al.  Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson’s Disease , 2014, Cell.

[5]  S. Bardien,et al.  EIF4G1 R1205H and VPS35 D620N mutations are rare in Parkinson's disease from South Africa , 2014, Neurobiology of Aging.

[6]  C. Burd,et al.  Retromer: a master conductor of endosome sorting. , 2014, Cold Spring Harbor perspectives in biology.

[7]  Mohamad Saad,et al.  Genetic comorbidities in Parkinson's disease. , 2014, Human molecular genetics.

[8]  T. Ideker,et al.  Exome Sequencing Links Corticospinal Motor Neuron Disease to Common Neurodegenerative Disorders , 2014, Science.

[9]  M. Frick,et al.  Surfactant Secretion in LRRK2 Knock-Out Rats: Changes in Lamellar Body Morphology and Rate of Exocytosis , 2014, PloS one.

[10]  C. Burd,et al.  A mechanism for retromer endosomal coat complex assembly with cargo , 2013, Proceedings of the National Academy of Sciences.

[11]  Nancy Y. Villa,et al.  Human Eukaryotic Initiation Factor 4G (eIF4G) Protein Binds to eIF3c, -d, and -e to Promote mRNA Recruitment to the Ribosome* , 2013, The Journal of Biological Chemistry.

[12]  U. Muthane,et al.  VPS35 and EIF4G1 mutations are rare in Parkinson's disease among Indians , 2013, Neurobiology of Aging.

[13]  Y. Teo,et al.  Patterns of Linkage Disequilibrium of LRRK2 across Different Races: Implications for Genetic Association Studies , 2013, PloS one.

[14]  Vladimir Makarov,et al.  The Sac1 Domain of SYNJ1 Identified Mutated in a Family with Early‐Onset Progressive Parkinsonism with Generalized Seizures , 2013, Human mutation.

[15]  S. Pappatà,et al.  Mutation in the SYNJ1 Gene Associated with Autosomal Recessive, Early‐Onset Parkinsonism , 2013, Human mutation.

[16]  M. Farrer,et al.  Advances in the genetics of Parkinson disease , 2013, Nature Reviews Neurology.

[17]  K. Lunetta,et al.  Association of TREM2 variants with Alzheimer's disease in African-Americans: For the Alzheimer's Disease Genetics Consortium (ADGC) , 2013, Alzheimer's & Dementia.

[18]  M. Pericak-Vance,et al.  Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP) , 2013, Translational Psychiatry.

[19]  K. Majamaa,et al.  Mutations in EIF4G1 are not a common cause of Parkinson's disease , 2013, European journal of neurology.

[20]  E. Masliah,et al.  Axonopathy in an α-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated α-synuclein. , 2013, The American journal of pathology.

[21]  K. Marder,et al.  RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk , 2013, Neuron.

[22]  A. Amon,et al.  Aneuploidy causes proteotoxic stress in yeast. , 2012, Genes & development.

[23]  J. Trojanowski,et al.  Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice , 2012, Science.

[24]  P. S. St George-Hyslop,et al.  Vps10 Family Proteins and the Retromer Complex in Aging-Related Neurodegeneration and Diabetes , 2012, The Journal of Neuroscience.

[25]  A. Bonnet,et al.  EIF4G1 in familial Parkinson's disease: pathogenic mutations or rare benign variants? , 2012, Neurobiology of Aging.

[26]  C. Reitz.  The role of intracellular trafficking and the VPS10d receptors in Alzheimer's disease. , 2012, Future neurology.

[27]  J. Hardy,et al.  Study of the genetic variability in a Parkinson's Disease gene: EIF4G1 , 2012, Neuroscience Letters.

[28]  J. Massano,et al.  Clinical approach to Parkinson's disease: features, diagnosis, and principles of management. , 2012, Cold Spring Harbor perspectives in medicine.

[29]  Chuong B. Do,et al.  Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database , 2012, PLoS genetics.

[30]  P. Walter,et al.  The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation , 2011, Science.

[31]  Tapan P. Patel,et al.  Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death , 2011, Neuron.

[32]  Michael K. Hutchinson,et al.  Translation initiator EIF4G1 mutations in familial Parkinson disease. , 2011, American journal of human genetics.

[33]  M. Farrer,et al.  VPS35 mutations in Parkinson disease. , 2011, American journal of human genetics.

[34]  Ying Sun,et al.  Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies , 2011, Cell.

[35]  Nicholas Eriksson,et al.  Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease , 2011, PLoS genetics.

[36]  Simon C. Potter,et al.  A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease , 2011, PLoS genetics.

[37]  Mohamad Saad,et al.  Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies , 2011, The Lancet.

[38]  Sarah E. Walker,et al.  Multiple elements in the eIF4G1 N‐terminus promote assembly of eIF4G1•PABP mRNPs in vivo , 2011, The EMBO journal.

[39]  H. Feldman,et al.  Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin , 2010, Neuron.

[40]  T. Golde,et al.  Sorting Out Frontotemporal Dementia? , 2010, Neuron.

[41]  J. Nutt,et al.  Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson’s disease , 2010, Nature Genetics.

[42]  Emily K. Lehrman,et al.  Two Cyclin-Dependent Kinase Pathways Are Essential for Polarized Trafficking of Presynaptic Components , 2010, Cell.

[43]  A. Gitler,et al.  GTPase Activity Plays a Key Role in the Pathobiology of LRRK2 , 2010, PLoS genetics.

[44]  J. Doudna,et al.  Functional Overlap between eIF4G Isoforms in Saccharomyces cerevisiae , 2010, PloS one.

[45]  Yusuke Nakamura,et al.  Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease , 2009, Nature Genetics.

[46]  E. Masliah,et al.  Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body Diseases , 2009, The Journal of Neuroscience.

[47]  Sonja W. Scholz,et al.  Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease , 2009, Nature Genetics.

[48]  E. Mufson,et al.  Brainstem Alzheimer's-like pathology in the triple transgenic mouse model of Alzheimer's disease , 2009, Neurobiology of Disease.

[49]  M. Zeviani,et al.  Faculty Opinions recommendation of Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. , 2009 .

[50]  D. Karger,et al.  Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity , 2009, Nature Genetics.

[51]  U. Baumann,et al.  Crystal structure of the yeast eIF4A-eIF4G complex: An RNA-helicase controlled by protein–protein interactions , 2008, Proceedings of the National Academy of Sciences.

[52]  E. Masliah,et al.  Statins reduce neuronal α‐synuclein aggregation in in vitro models of Parkinson’s disease , 2008, Journal of neurochemistry.

[53]  J. Jankovic.  Parkinson’s disease: clinical features and diagnosis , 2008, Journal of Neurology, Neurosurgery, and Psychiatry.

[54]  A. Gitler.  Beer and Bread to Brains and Beyond: Can Yeast Cells Teach Us about Neurodegenerative Disease? , 2007, Neurosignals.

[55]  J. Shorter.  Hsp104: A Weapon to Combat Diverse Neurodegenerative Disorders , 2007, Neurosignals.

[56]  K. Shen,et al.  Wnt Signaling Positions Neuromuscular Connectivity by Inhibiting Synapse Formation in C. elegans , 2007, Cell.

[57]  J. Hay.  Faculty Opinions recommendation of Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. , 2007 .

[58]  J. Trojanowski,et al.  Mechanisms of Parkinson's Disease Linked to Pathological α-Synuclein: New Targets for Drug Discovery , 2006, Neuron.

[59]  S. Lindquist,et al.  α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models , 2006, Science.

[60]  Sean R. Collins,et al.  A strategy for extracting and analyzing large-scale quantitative epistatic interaction data , 2006, Genome Biology.

[61]  Sunhong Kim,et al.  Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin , 2006, Nature.

[62]  Changan Jiang,et al.  Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin , 2006, Nature.

[63]  Andrew B West,et al.  Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[64]  David Botstein,et al.  GO: : TermFinder--open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes , 2004, Bioinform..

[65]  John Q Trojanowski,et al.  Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs , 2004, Nature Medicine.

[66]  S. Lindquist,et al.  Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology , 2003, Science.

[67]  Janel O. Johnson,et al.  α-Synuclein Locus Triplication Causes Parkinson's Disease , 2003, Science.

[68]  Patrizia Rizzu,et al.  Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism , 2002, Science.

[69]  Makoto Hashimoto,et al.  Differential neuropathological alterations in transgenic mice expressing α‐synuclein from the platelet‐derived growth factor and Thy‐1 promoters , 2002, Journal of neuroscience research.

[70]  P. Madsen,et al.  The Yeast Vps10p Cytoplasmic Tail Mediates Lysosomal Sorting in Mammalian Cells and Interacts with Human GGAs* , 2002, The Journal of Biological Chemistry.

[71]  P. Walter,et al.  Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. , 2001, Current opinion in cell biology.

[72]  P. Steiner,et al.  Syntaxin 13 is a developmentally regulated SNARE involved in neurite outgrowth and endosomal trafficking , 2000, The European journal of neuroscience.

[73]  L. Mucke,et al.  Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. , 2000, Science.

[74]  S. Lovestone,et al.  UK Alzheimer's Disease Genetics Consortium , 1999, International journal of geriatric psychiatry.

[75]  Scott D. Emr,et al.  A Membrane Coat Complex Essential for Endosome-to-Golgi Retrograde Transport in Yeast , 1998, The Journal of cell biology.

[76]  H. Payami,et al.  Genetic Epidemiology of Parkinson's Disease , 1998, Journal of geriatric psychiatry and neurology.

[77]  S. Emr,et al.  Endosome to Golgi Retrieval of the Vacuolar Protein Sorting Receptor, Vps10p, Requires the Function of the VPS29, VPS30, and VPS35 Gene Products , 1997, The Journal of cell biology.

[78]  V. Bonifati.  Genetics of Parkinson's disease--state of the art, 2013. , 2014, Parkinsonism & related disorders.

[79]  A. Samii,et al.  Association mapping of the PARK10 region for Parkinson's disease susceptibility genes. , 2014, Parkinsonism & related disorders.

[80]  A. Tong,et al.  Synthetic genetic array analysis in Saccharomyces cerevisiae. , 2006, Methods in molecular biology.

[81]  A. Singleton,et al.  alpha-Synuclein locus triplication causes Parkinson's disease. , 2003, Science.