Long-range restriction map of a region of human chromosome 19 containing the apolipoprotein genes, a CLL-associated translocation breakpoint, and two polymorphic MluI sites

SummaryThe apolipoprotein gene cluster on human chromosome 19 (APOC1, APOC2, APOE) has been localised by pulsed-field gel electrophoresis to within 200 kb of a chronic lymphocytic leukemia-associated translocation breakpoint. A restriction map covering 1300 kb around these loci has been constructed and contains two polymorphic MluI sites, which appear to show Mendelian inheritance. The orientation of the map on the chromosome has been established as 19cen CLL breakpoint-APOC2-19qter. Pedigree analysis using APOC2, a probe derived from the CLL breakpoint, and other localised markers on 19q suggests that the myotonic dystrophy locus is distal to APOC2 on 19q.

[1]  D. Shaw,et al.  Further mapping of markers around the centromere of human chromosome 19. , 1987, Genomics.

[2]  H. Eiberg,et al.  Report of the committee for chromosomes 17, 18, and 19. , 1987, Cytogenetics and cell genetics.

[3]  Regional localisations and linkage relationships of seven RFLPs and myotonic dystrophy on chromosome 19 , 1986, Human Genetics.

[4]  The apolipoprotein CII gene: Subchromosomal localisation and linkage to the myotonic dystrophy locus , 1985, Human Genetics.

[5]  C. L. Jackson,et al.  Localization of a human Na+,K+-ATPase alpha subunit gene to chromosome 19q12----q13.2 and linkage to the myotonic dystrophy locus. , 1988, Genomics.

[6]  R. Stallings,et al.  Human creatine kinase genes on chromosomes 15 and 19, and proximity of the gene for the muscle form to the genes for apolipoprotein C2 and excision repair. , 1988, American journal of human genetics.

[7]  K. Davies,et al.  Human genetic diseases : a practical approach , 1986 .

[8]  O. Myklebost,et al.  A physical map of the apolipoprotein gene cluster on human chromosome 19 , 1988, Human Genetics.

[9]  C. Shelley,et al.  Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance. , 1984, Nucleic acids research.

[10]  R. Hochstenbach,et al.  Toward early diagnosis of myotonic dystrophy: construction and characterization of a somatic cell hybrid with a single human der(19) chromosome. , 1986, Cytogenetics and cell genetics.

[11]  J. Scott,et al.  Localization of genes encoding apolipoproteins CI, CII, and E to the p13→cen region of human chromosome 19 , 2004, Human Genetics.

[12]  Ronald W. Davis,et al.  Resolution of DNA molecules greater than 5 megabases by contour-clamped homogeneous electric fields. , 1987, Nucleic acids research.

[13]  J. Rowley,et al.  Cloning of the chromosome translocation breakpoint junction of the t(14;19) in chronic lymphocytic leukemia. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[14]  R. Korneluk,et al.  A chromosome 19 clone from a translocation breakpoint shows close linkage and linkage disequilibrium with myotonic dystrophy. , 1989, Genomics.

[15]  R. W. Davis,et al.  Separation of large DNA molecules by contour-clamped homogeneous electric fields. , 1986, Science.

[16]  F. Oerlemans,et al.  Definition of subchromosomal intervals around the myotonic dystrophy gene region at 19q. , 1989, Genomics.

[17]  A. Bird,et al.  Use of restriction enzymes to detect potential gene sequences in mammalian DNA , 1987, Nature.

[18]  Y. Nakamura,et al.  A primary map of ten DNA markers and two serological markers for human chromosome 19. , 1988, Genomics.

[19]  E. Nanba,et al.  [Myotonic dystrophy]. , 2005, Nihon rinsho. Japanese journal of clinical medicine.