A comparative evaluation of oral midazolam with other sedatives as premedication in pediatric dentistry.

The purpose of present study was to evaluate the safety and efficacy of orally administered midazolam in children as a sedative agent and to compare it with two other older agents, triclofos and promethazine. The study was conducted on ninety child patients requiring some short dental procedure. All the patients were with a good physical status (ASA-I). The ages ranged between 3 and 9 years. The patients were randomized into three study groups: Group 1, midazolam, Group II, triclofos and Group III, promethazine, on the basis of the drugs to be administered. After administration of drugs in each group, the effects were evaluated in terms of onset of action, sedative effect, ease of treatment completion, recovery time and postoperative amnesia. Midazolam was found to be the best drug among the three to produce conscious sedation in children.

[1]  K. Chan-Tack,et al.  Neuroleptic malignant syndrome due to promethazine. , 1999, Southern medical journal.

[2]  F. Davies,et al.  Oral midazolam for conscious sedation of children during minor procedures. , 1998, Journal of accident & emergency medicine.

[3]  M. Pinaud,et al.  Premedication with midazolam in children. Effect of intranasal, rectal and oral routes on plasma midazolam concentrations , 1995, Anaesthesia.

[4]  P Milgrom,et al.  Origins of childhood dental fear. , 1995, Behaviour research and therapy.

[5]  A. Timmins,et al.  Adrenaline administered via a nebulizer in adult patients with upper airway obstruction , 1995, Anaesthesia.

[6]  S. Fuchs,et al.  Efficacy of rectal midazolam for the sedation of preschool children undergoing laceration repair. , 1994, Annals of emergency medicine.

[7]  T. Silver,et al.  Evaluation of two dosages of oral midazolam as a conscious sedation for physically and neurologically compromised pediatric dental patients. , 1994, Pediatric dentistry.

[8]  S. Curry,et al.  Effect of the cyanide antidote hydroxocobalamin on commonly ordered serum chemistry studies. , 1994, Annals of emergency medicine.

[9]  I. Kl.  Midazolam in emergency surgery--a pilot study on adult Nigerian patients. , 1994 .

[10]  R. Borie,et al.  Oral midazolam as premedication for the apprehensive child before dental treatment. , 1994, The Journal of clinical pediatric dentistry.

[11]  J. Lerman,et al.  Oral midazolam premedication in children: the minimum time interval for separation from parents , 1993, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

[12]  B. V. van Engelen,et al.  Benzodiazepine Withdrawal Reaction in Two Children following Discontinuation of Sedation with Midazolam , 1993, The Annals of pharmacotherapy.

[13]  J. Stocks,et al.  The effect of triclofos sodium sedation on respiratory rate, oxygen saturation, and heart rate in infants and young children , 1991, Pediatric pulmonology.

[14]  J. Hoogstraten,et al.  Prevalence of dental anxiety in The Netherlands. , 1990, Community dentistry and oral epidemiology.

[15]  W. Tolksdorf,et al.  [Midazolam for premedication of infants. A comparison of the effect between oral and rectal administration]. , 1989, Anasthesie, Intensivtherapie, Notfallmedizin.

[16]  J. Himberg,et al.  Comparison of oral triclofos, diazepam and flunitrazepam as premedicants in children undergoing otolaryngological surgery. , 1980, British journal of anaesthesia.

[17]  J. Orwin,et al.  Safety of chloral. , 1968, British medical journal.

[18]  M. Sadove,et al.  The Use of Promethazine for Premedication. , 1958, Journal of the American Dental Society of Anesthesiology.

[19]  W. A. Weiss,et al.  Promethazine, an Adjunct to Preoperative Medication , 1956, Annals of surgery.