Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens.

Helicobacter pylori is associated with development of gastritis, gastric ulcers, and adenocarcinomas in humans. The Lewis(b) (Le(b)) blood group antigen mediates H. pylori attachment to human gastric mucosa. Soluble glycoproteins presenting the Leb antigen or antibodies to the Leb antigen inhibited bacterial binding. Gastric tissue lacking Leb expression did not bind H. pylori. Bacteria did not bind to Leb antigen substituted with a terminal GalNAc alpha 1-3 residue (blood group A determinant), suggesting that the availability of H. pylori receptors might be reduced in individuals of blood group A and B phenotypes, as compared with blood group O individuals.

[1]  G. Larson,et al.  Degradation of human intestinal glycosphingolipids by extracellular glycosidases from mucin-degrading bacteria of the human fecal flora. , 1988, The Journal of biological chemistry.

[2]  J. Paulson,et al.  Glycosyltransferases. Structure, localization, and control of cell type-specific glycosylation. , 1989, The Journal of biological chemistry.

[3]  M. Blaser,et al.  Adherence of Helicobacter pylori cells and their surface components to HeLa cell membranes. , 1990, Microbial pathogenesis.

[4]  G. Strecker,et al.  Specificity of Twelve Lectins Towards Oligosaccharides and Glycopeptides Related to N‐Glycosylproteins , 2005 .

[5]  M. Breimer,et al.  Novel polyfucosylated N-linked glycopeptides with blood group A, H, X, and Y determinants from human small intestinal epithelial cells. , 1989, The Journal of biological chemistry.

[6]  S. Hakomori,et al.  ABH and Related Histo‐Blood Group Antigens; Immunochemical Differences in Carrier Isotypes and Their Distribution 1 , 1989, Vox sanguinis.

[7]  K. Karlsson,et al.  Carbohydrate-specific adhesion of bacteria to thin-layer chromatograms: a rationalized approach to the study of host cell glycolipid receptors. , 1985, Analytical biochemistry.

[8]  A. Mentis,et al.  ABO blood group, secretor status and detection of Helicobacter pylori among patients with gastric or duodenal ulcers , 1991, Epidemiology and Infection.

[9]  S. Kresovich,et al.  DNA diversity among clinical isolates of Helicobacter pylori detected by PCR-based RAPD fingerprinting. , 1992, Nucleic acids research.

[10]  K. Sugano,et al.  Identification of glycolipid receptors for Helicobacter pylori by TLC‐immunostaining , 1991, FEBS letters.

[11]  D. Graham,et al.  Effect of age on the frequency of active Campylobacter pylori infection diagnosed by the [13C]urea breath test in normal subjects and patients with peptic ulcer disease. , 1988, The Journal of infectious diseases.

[12]  M. Blaser,et al.  Seroprevalence of Helicobacter pylori infections in Thailand. , 1990, The Journal of infectious diseases.

[13]  S. Cusack,et al.  Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid , 1988, Nature.

[14]  K. Karlsson.  Animal glycosphingolipids as membrane attachment sites for bacteria. , 1989, Annual review of biochemistry.

[15]  D. Evans,et al.  Cloning, nucleotide sequence, and expression of a gene encoding an adhesin subunit protein of Helicobacter pylori , 1993, Journal of bacteriology.

[16]  S. Kornfeld,et al.  Structure of the carbohydrate units of IgA1 immunoglobulin. I. Composition, glycopeptide isolation, and structure of the asparagine-linked oligosaccharide units. , 1974, The Journal of biological chemistry.

[17]  K. Lloyd,et al.  Expression of Lewisa, Lewisb, Lewisx, Lewisy, siayl-Lewisa, and sialyl-Lewisx blood group antigens in human gastric carcinoma and in normal gastric tissue. , 1989, Cancer research.

[18]  J. Gordon,et al.  An in vitro adherence assay reveals that Helicobacter pylori exhibits cell lineage-specific tropism in the human gastric epithelium. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[19]  D. Forman,et al.  An international association between Helicobacter pylori infection and gastric cancer , 1993 .

[20]  D. Graham.  I. Helicobacter pylori: Its epidemiology and its role in duodenal ulcer disease , 1991, Journal of gastroenterology and hepatology.

[21]  P. Falk,et al.  ヒトの胃の上皮細胞でのHelicobacter pylori細胞の系統特異的な親和性を表すことを示すin vitroでの付着解析 , 1993 .