Effect of injected heparin on platelet levels in man

Platelets from six normal subjects were labelled with radiochromate and reinfused into their donors. Subsequently, the effect of intravenously injected heparin upon the levels of circulating platelets and platelet radioactivity was studied. Although reductions in platelet counts occurred in three subjects following single injections of 10,000 units, these changes were not reflected in the levels of circulating platelet radioactivity. It is concluded that the alterations in platelet counts observed were probably due to an effect of heparin in vitro. The experimental evidence that heparin induces thrombocytopenia in vivo, in man, is unconvincing.

[1]  U. Abildgaard,et al.  THE SYMPTOMATIC EFFECT OF ANTICOAGULANT THERAPY IN DEFIBRINATION SYNDROME ASSOCIATED WITH DEMONSTRABLE FIBRIN IN PLASMA: A CASE REPORT. , 2009, Acta medica Scandinavica.

[2]  C. Borchgrevink.  The mechanism of the prolonged bleeding time provoked by dextran sulphate or by excessive doses of heparin. , 2009, Acta medica Scandinavica.

[3]  S. Johansson,et al.  Influence of heparin on thrombocytopenia in allergic reactions. , 2009, Acta medica Scandinavica.

[4]  F. Gardner,et al.  DESTRUCTION OF CANINE AND RABBIT PLATELETS FOLLOWING INTRAVENOUS ADMINISTRATION OF CARBON PARTICLES OR ENDOTOXIN. , 1965, The Journal of laboratory and clinical medicine.

[5]  M. Verstraete,et al.  EXCESSIVE CONSUMPTION OF BLOOD COAGULATION COMPONENTS AS CAUSE OF HEMORRHAGIC DIATHESIS. , 1965, The American journal of medicine.

[6]  S. Gollub,et al.  SOME VARIABLES AFFECTING HEMOSTASIS IN CARDIOPULMONARY BYPASS * , 1964, Annals of the New York Academy of Sciences.

[7]  H. Lander,et al.  The Behaviour of Infused Human Platelets During the First Twenty‐Four Hours After Infusion , 1964, British journal of haematology.

[8]  H. Lander,et al.  THE LABELLING OF HUMAN PLATELETS WITH RADIOCHROMATE. , 1963, The Australian journal of experimental biology and medical science.

[9]  H. Rowsell,et al.  Heparin and Thrombus Formation: Early Suppression and Late Enhancement * , 1963, British journal of haematology.

[10]  A. Amery,et al.  Heparin treatment of bleeding. , 1963, Lancet.

[11]  A. Ulin,et al.  Heparin-induced thrombocytopenia in man. , 1962, The Journal of laboratory and clinical medicine.

[12]  W. Krivit,et al.  Problems in hemostasis during openheart surgery. IV. On the changes in the blood clotting mechanism during cardiopulmonary bypass procedures. , 1962, Annals of surgery.

[13]  A. Bloom.  Changes in Blood After Using an Extracorporeal Circulation , 1961, British medical journal.

[14]  Viking Olov BjöUrk.  AN EFFECTIVE BLOOD HEAT EXCHANGER FOR DEEP HYPOTHERMIA IN ASSOCIATION WITH EXTRACORPOREAL CIRCULATION BUT EXCLUDING THE OXYGENATOR , 1960 .

[15]  Bigelow Wg,et al.  The use of heparin to minimize thrombocytopenia and bleeding tendency during hypothermia. , 1959 .

[16]  H. Perkins,et al.  The effect of heparin on the platelet count in vitro, with particular reference to the collection of blood for extracorporeal circulation. , 1958, American journal of clinical pathology.

[17]  E. Cronkite,et al.  Morphology and enumeration of human blood platelets. , 1950, Journal of applied physiology.

[18]  Jaques Lb,et al.  The effect of commercial heparin on the platelet count. , 1948, The Journal of laboratory and clinical medicine.

[19]  J. Shanberge,et al.  The effect of heparin on platelets in vivo. , 1948, The Journal of laboratory and clinical medicine.

[20]  P. Owren,et al.  Parahaemophilia; haemorrhagic diathesis due to absence of a previously unknown clotting factor. , 1947, Lancet.

[21]  A. Copley,et al.  Studies on Platelets: II. The Effect of Heparin on the Platelet Count in Vitro , 1942 .

[22]  S. Zail,et al.  Effect of ethanol on liver 8-aminolaevulinate synthetase in rats. , 1968 .

[23]  E. Cronkite,et al.  The reproducibility and constancy of the platelet count. , 1953, American journal of clinical pathology.