Microwave-Assisted Three-Component Reaction for Rapid Synthesis of Some 5,6-Dihydro-4H-1,3-thiazine Derivatives Under Solvent-Free Conditions

Microwave irradiation was found to efficiently promote the three-component reaction of aromatic aldehyde, thiourea, and vinylbenzene at the presence of TMSCl. The products of 5,6-dihydro-4H-1,3-thiazines were formed in a very short time with good to excellent yields as well as excellent diastereoselectivity. This newly developed protocol provided a much more facile route of preparing functionalized thiazine compounds. [Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental.]

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