An Inhomogeneous Model of Protein Dielectric Properties: Intrinsic Polarizabilities of Amino Acids

A simple inhomogeneous model of protein dielectric properties is discussed. A protein in solution is modeled as a collection of polarizable dipoles in a cavity embedded inside a dielectric medium. The intrinsic polarizabilities of 20 amino acids are assumed to be portable to all proteins in nature. A reasonable set of these polarizability values has been obtained by comparing dielectric fluctuations from molecular dynamics simulations with model calculations. The results are consistent within a data set of three small proteins.

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