Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function
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Christine L. Mummery | Robert Passier | Pier G. Mastroberardino | D. Atsma | R. Passier | C. Mummery | Richard P. Davis | P. Mastroberardino | V. van de Pol | D. Ward | Matthew J. Birket | H. Devalla | Douwe E. Atsma | Georgios Kosmidis | Ana Rita Canhoto Leitoguinho | Marcelo C. Ribeiro | Dorien Ward | Ana Rita Leitoguinho | Vera van de Pol | Cheryl Dambrot | Harsha D. Devalla | Marcelo C Ribeiro | G. Kosmidis | C. Dambrot | Dorien Ward | M. Birket
[1] L. Carrier,et al. Cardiac Myosin-Binding Protein C Is Required for Complete Relaxation in Intact Myocytes , 2007, Circulation research.
[2] V. Regitz-Zagrosek,et al. The 2373insG mutation in the MYBPC3 gene is a founder mutation, which accounts for nearly one-fourth of the HCM cases in the Netherlands. , 2003, European heart journal.
[3] R. Graham,et al. Thyroid hormone action in postnatal heart development. , 2014, Stem cell research.
[4] Irwin Klein,et al. Hypothyroidism as a risk factor for cardiovascular disease , 2004, Endocrine.
[5] K. McDonald,et al. Hypertrophic Cardiomyopathy in Cardiac Myosin Binding Protein-C Knockout Mice , 2002, Circulation research.
[6] S. Ikeda,et al. Transcription Factor GATA4 Is Activated but Not Required for Insulin-like Growth Factor 1 (IGF1)-induced Cardiac Hypertrophy* , 2012, The Journal of Biological Chemistry.
[7] M. Hey‐Mogensen,et al. Sites of Superoxide and Hydrogen Peroxide Production by Muscle Mitochondria Assessed ex Vivo under Conditions Mimicking Rest and Exercise* , 2014, The Journal of Biological Chemistry.
[8] Paul M. Rindler,et al. The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response , 2014, Cell.
[9] T. Wieland,et al. β-Adrenergic receptor stimulation causes cardiac hypertrophy via a Gβγ/Erk-dependent pathway. , 2012, Cardiovascular research.
[10] A. Mugelli,et al. The effect of oxygen free radicals on calcium current and dihydropyridine binding sites in guinea‐pig ventricular myocytes , 1996, British journal of pharmacology.
[11] Shiyong Wu,et al. The Warburg effect: evolving interpretations of an established concept. , 2015, Free radical biology & medicine.
[12] N. Laping,et al. Development of a small-molecule serum- and glucocorticoid-regulated kinase-1 antagonist and its evaluation as a prostate cancer therapeutic. , 2008, Cancer research.
[13] George A. Truskey,et al. Modeling the mitochondrial cardiomyopathy of Barth syndrome with iPSC and heart-on-chip technologies , 2014, Nature Medicine.
[14] J. Vicencio,et al. New insights into IGF-1 signaling in the heart , 2014, Trends in Endocrinology & Metabolism.
[15] E. Stanley,et al. A protocol describing the use of a recombinant protein-based, animal product-free medium (APEL) for human embryonic stem cell differentiation as spin embryoid bodies , 2008, Nature Protocols.
[16] Euan A Ashley,et al. Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. , 2013, Cell stem cell.
[17] Gang Wang,et al. Modeling the mitochondrial cardiomyopathy of Barth syndrome with iPSC and heart-on-chip technologies , 2014 .
[18] Yu-Li Wang,et al. The regulation of traction force in relation to cell shape and focal adhesions. , 2011, Biomaterials.
[19] L. Bertrand,et al. Role of Akt/GSK-3beta/beta-catenin transduction pathway in the muscle anti-atrophy action of insulin-like growth factor-I in glucocorticoid-treated rats. , 2008, Endocrinology.
[20] Milena Bellin,et al. Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: Disease mechanisms and pharmacological rescue , 2014, Proceedings of the National Academy of Sciences.
[21] D. Kelly,et al. Peroxisome Proliferator–Activated Receptor γ Coactivator-1 (PGC-1) Regulatory Cascade in Cardiac Physiology and Disease , 2007 .
[22] R. Passier,et al. Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells , 2015, Nature Biotechnology.
[23] C. Mummery,et al. PGC-1α and Reactive Oxygen Species Regulate Human Embryonic Stem Cell-Derived Cardiomyocyte Function , 2013, Stem cell reports.
[24] Chris Denning,et al. Aberrant α-Adrenergic Hypertrophic Response in Cardiomyocytes from Human Induced Pluripotent Cells , 2014, Stem cell reports.
[25] K. Gharbi,et al. Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α , 2014, Cell Death and Differentiation.
[26] D. Atsma,et al. Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes , 2014, Journal of cellular and molecular medicine.
[27] Florian Lang,et al. Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A. , 2003, Cardiovascular research.
[28] C. Rücker-Martin,et al. Human cardiomyocyte hypertrophy induced in vitro by gp130 stimulation. , 2003, Cardiovascular research.
[29] S. Bhattacharya,et al. Glucocorticoid receptor is required for foetal heart maturation. , 2013, Human molecular genetics.
[30] Lei Yang,et al. Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells , 2014, Cardiovascular research.
[31] Sean P. Palecek,et al. Effects of Substrate Mechanics on Contractility of Cardiomyocytes Generated from Human Pluripotent Stem Cells , 2012, International journal of cell biology.
[32] D. Chrysis,et al. Insulin-like growth factor-1 restores dexamethasone-induced heart growth arrest in rats: the role of the ubiquitin pathway , 2011, Hormones.
[33] Jane Synnergren,et al. Global transcriptional profiling reveals similarities and differences between human stem cell-derived cardiomyocyte clusters and heart tissue. , 2012, Physiological genomics.
[34] K. Kolaja,et al. Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells. , 2014, Cell reports.
[35] M. Burch,et al. Hypertrophic cardiomyopathy. , 1994, Archives of disease in childhood.
[36] James A Thomson,et al. High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. , 2011, American journal of physiology. Heart and circulatory physiology.
[37] Richard P Davis,et al. Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes Under Defined Conditions. , 2016, Methods in molecular biology.
[38] T. Eschenhagen,et al. β-Adrenergic stimulation and myocardial function in the failing heart , 2009, Heart Failure Reviews.
[39] C. Proud,et al. p90(RSK)s mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes. , 2013, Journal of molecular and cellular cardiology.
[40] D. Guertin,et al. Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex , 2005, Science.
[41] R. Passier,et al. NKX2-5eGFP/w hESCs for isolation of human cardiac progenitors and cardiomyocytes , 2011, Nature Methods.
[42] S. Heymans,et al. Mutations in MYH7 reduce the force generating capacity of sarcomeres in human familial hypertrophic cardiomyopathy. , 2013, Cardiovascular research.
[43] Simona Casini,et al. Immaturity of human stem-cell-derived cardiomyocytes in culture: fatal flaw or soluble problem? , 2015, Stem cells and development.
[44] J. Magyar,et al. Effects of endothelin-1 on calcium and potassium currents in undiseased human ventricular myocytes , 2000, Pflügers Archiv.
[45] C. Chinopoulos,et al. Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium‐induced de‐ and hyperpolarization of neuronal mitochondria , 2012, The Journal of physiology.
[46] M. Gautel,et al. A newly created splice donor site in exon 25 of the MyBP-C gene is responsible for inherited hypertrophic cardiomyopathy with incomplete disease penetrance. , 2000, Circulation.
[47] E. Bettiol,et al. Developmental Changes in Cardiomyocytes Differentiated from Human Embryonic Stem Cells: A Molecular and Electrophysiological Approach , 2007, Stem cells.
[48] Robert Passier,et al. Functional maturation of human pluripotent stem cell derived cardiomyocytes in vitro--correlation between contraction force and electrophysiology. , 2015, Biomaterials.
[49] F J Schoen,et al. Comparison of Two Murine Models of Familial Hypertrophic Cardiomyopathy , 2001, Circulation research.
[50] L. Sen,et al. Acute effects of thyroid hormone on inward rectifier potassium channel currents in guinea pig ventricular myocytes. , 1996, Endocrinology.
[51] D. Discher,et al. Microscopic methods for measuring the elasticity of gel substrates for cell culture: microspheres, microindenters, and atomic force microscopy. , 2007, Methods in cell biology.
[52] G. Pazour,et al. The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation , 2009, Journal of Cell Science.
[53] Simona Casini,et al. Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome , 2013, The EMBO journal.
[54] M. Heymans,et al. Preserved cross-bridge kinetics in human hypertrophic cardiomyopathy patients with MYBPC3 mutations , 2014, Pflügers Archiv - European Journal of Physiology.
[55] E. Wouters,et al. Synergistic stimulation of myogenesis by glucocorticoid and IGF-I signaling. , 2013, Journal of applied physiology.
[56] I. Klein,et al. Triiodothyronine-mediated myosin heavy chain gene transcription in the heart. , 2003, American journal of physiology. Heart and circulatory physiology.
[57] Thomas Eschenhagen,et al. Contractile abnormalities and altered drug response in engineered heart tissue from Mybpc3-targeted knock-in mice. , 2013, Journal of molecular and cellular cardiology.
[58] F. Weinberger,et al. Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice , 2012, Journal of molecular and cellular cardiology.
[59] F. T. ten Cate,et al. Cardiac Myosin-Binding Protein C Mutations and Hypertrophic Cardiomyopathy: Haploinsufficiency, Deranged Phosphorylation, and Cardiomyocyte Dysfunction , 2009, Circulation.
[60] G. Ratto,et al. Amiodarone inhibits the 3,5,3'-triiodothyronine-dependent increase of sodium/potassium adenosine triphosphatase activity and concentration in human atrial myocardial tissue. , 2004, Thyroid : official journal of the American Thyroid Association.
[61] S. Dudley,et al. Reactive Oxygen Species Originating From Mitochondria Regulate the Cardiac Sodium Channel , 2010, Circulation research.
[62] C. Mummery,et al. Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes , 2015, Cardiovascular research.
[63] H. Ruohola-Baker,et al. Tri-iodo-l-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells. , 2014, Journal of molecular and cellular cardiology.
[64] Hirotoshi Nakamura,et al. Essential Role of TEA Domain Transcription Factors in the Negative Regulation of the MYH 7 Gene by Thyroid Hormone and Its Receptors , 2014, PloS one.
[65] J. Seidman,et al. Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice. , 2015, Journal of molecular and cellular cardiology.
[66] M. Brand,et al. The contributions of respiration and glycolysis to extracellular acid production. , 2015, Biochimica et biophysica acta.
[67] Sean P. Palecek,et al. Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells , 2009, Circulation research.
[68] C. Stournaras,et al. Regulation of transport across cell membranes by the serum- and glucocorticoid-inducible kinase SGK1 , 2014, Molecular membrane biology.
[69] R. Hamanaka,et al. Warburg Effect and Redox Balance , 2011, Science.
[70] D. Kelly,et al. Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease. , 2007, Circulation.