Dominating immune response Immunodominance and its significance in immunity

During the course of evolution, the immune system of higher vertebrates developed very sophisticated defence strategies. If a pathogen succeeds in invading an organism, two lines of defence become activated. The innate immunity constitutes the first and non-specific line, followed by the acquired immunity which specifically recognizes antigenic structures of the intruder. Of the many thousands of antigens that potentially can be presented to cells of the specific immune system, only a small fraction induces measurable responses. This immunodominance phenomenon results from a complex interplay of different factors which are still not fully understood. The question, why immunodominance developed and whether it serves a special purpose, is one of the hot topics in immunology.

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