A model of overall regulation of body fluids

A large-scale model of body fluid regulation was presented for the purpose of studying problems concerning body fluid disturbances and fluid therapy. This model, containing subsystems of circulation, respiration, renal function, and intra and extracellular fluid spaces, was described mathematically as a set of nonlinear differential and algebraic equations of more than 200 variables. A special feature is that the respiratory and renal subsystems are combined into one system, so that acid-base disturbances of body fluid can be simulated over a wide range of time scales. Behavior of the model for various kinds of inputs simulated with a digital computer was in good agreement with a number of experimental results pertaining to body fluid and acid-base disorders. The model presented in this paper is considered to have good applicability to some clinical problems and to be a useful framework for physiological experimental research.

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