The Efficiency of Using Mirror Imaged Topography in Fellow Eyes Analyses of Pentacam HR Data

Purpose: To investigate the effectiveness of flipping left corneas topography and analysethem quantitively along with fellow right corneas based on the assumption that they are mirror images of each other. Methods: The study involved scanning both eyes of 177 healthy participants (aged 35.3 ± 15.8) and 75 keratoconic participants (aged 33.9 ± 17.8). Clinical tomography data were collected for both eyes using the Pentacam HR and processed by a fully automated custom-built MATLAB code. For every case, the right eye was used as a datum fixed surface while the left cornea was flipped around in the superior–inferior direction. In this position, the root-mean-squared difference (RMS) between the flipped left cornea and the right cornea was initially determined for both the anterior and posterior corneal surfaces. Next, the iterative closest point transformation algorithm was applied on the three-dimensional flipped cornea to allow the flipped left corneal anterior surface to translate and rotate, minimising the difference between it and the right corneal anterior surface. Then, the RMS differences were recalculated and compared. Results: A comparison of the dioptric powers showed a significant difference between the RMS of both the flipped left eyes and the right eyes in the healthy and the KC groups (p < 0.001). The RMS of the surfaces of the flipped left corneas and the right corneas was 0.6 ± 0.4 D among the healthy group and 4.1 ± 2.3 among the KC group. After transforming the flipped left corneas, the RMS was recorded as 0.5 ± 0.3 D and 2.4 ± 2 D among the healthy and KC groups, respectively. Conclusions: Although fellow eyes are highly related in their clinical parameters, they should be treated with care when one eye topography is flipped and processed with the other eye topography in an optic-related research analysis where translation might be needed. In KC, an asymmetric disease, it was observed that a portion of the asymmetry was due to a corneal apex shift interfering with the image acquisition. Therefore, transforming the flipped left eyes by rotation and translation results in a fairer comparison between the fellow KC corneas.

[1]  Bozo Vojniković,et al.  Gullstrand's optical schematic system of the eye--modified by Vojniković & Tamajo. , 2013, Collegium antropologicum.

[2]  Ahmed Elsheikh,et al.  Non-Orthogonal Corneal Astigmatism among Normal and Keratoconic Brazilian and Chinese populations , 2018, Current eye research.

[3]  T. Olsen.  On the calculation of power from curvature of the cornea. , 1986, The British journal of ophthalmology.

[4]  J. Krachmer,et al.  Keratoconus and related noninflammatory corneal thinning disorders. , 1984, Survey of ophthalmology.

[5]  Z. Nagy,et al.  Evaluation of Intereye Corneal Asymmetry in Patients with Keratoconus. A Scheimpflug Imaging Study , 2014, PloS one.

[6]  W. Ehrenstein,et al.  Eye preference within the context of binocular functions , 2005, Graefe's Archive for Clinical and Experimental Ophthalmology.

[7]  O Bergamin,et al.  Three-dimensional binocular kinematics of torsional vestibular nystagmus during convergence on head-fixed targets in humans. , 2001, Journal of neurophysiology.

[8]  M. Reiss,et al.  Ocular dominance: some family data. , 1997, Laterality.

[9]  D. O’Brart,et al.  A review of keratoconus: Diagnosis, pathophysiology, and genetics. , 2017, Survey of ophthalmology.

[10]  Bernardo T. Lopes,et al.  Positions of Ocular Geometrical and Visual Axes in Brazilian, Chinese and Italian Populations , 2018, Current eye research.

[11]  Pablo Artal,et al.  Minimum amount of astigmatism that should be corrected , 2014, Journal of cataract and refractive surgery.

[12]  Edwin J Sarver,et al.  Inattention to nonsuperimposable midline symmetry causes wavefront analysis error. , 2002, Archives of ophthalmology.

[13]  F. Cavas-Martínez,et al.  Corneal topography in keratoconus: state of the art , 2016, Eye and Vision.

[14]  A. Elsheikh,et al.  Evaluation of the Shape Symmetry of Bilateral Normal Corneas in a Chinese Population , 2013, PloS one.

[15]  J. Meunier,et al.  Corneal Shape, Volume, and Interocular Symmetry: Parameters to Optimize the Design of Biosynthetic Corneal Substitutes. , 2015, Investigative ophthalmology & visual science.

[16]  David P. Piñero,et al.  Assessment of Pattern and Shape Symmetry of Bilateral Normal Corneas by Scheimpflug Technology , 2018, Symmetry.

[17]  R. Tsai,et al.  Validity of the keratometric index: Evaluation by the Pentacam rotating Scheimpflug camera , 2008, Journal of cataract and refractive surgery.