A novel method for coupling doxorubicin to lactosaminated human albumin by an acid sensitive hydrazone bond: synthesis, characterization and preliminary biological properties of the conjugate.

[1]  M. Derenzini,et al.  Liver‐targeted doxorubicin: effects on rat regenerating hepatocytes , 2004, Liver international : official journal of the International Association for the Study of the Liver.

[2]  F. Kratz,et al.  Doxorubicin coupled to lactosaminated human albumin remains confined within mouse liver cells after the intracellular release from the carrier. , 2003, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[3]  D. Rognan,et al.  Probing the cysteine-34 position of endogenous serum albumin with thiol-binding doxorubicin derivatives. Improved efficacy of an acid-sensitive doxorubicin derivative with specific albumin-binding properties compared to that of the parent compound. , 2002, Journal of medicinal chemistry.

[4]  P. Ambroise‐Thomas,et al.  Efficacy and safety of lactosaminated human serum albumin-adenine arabinoside monophosphate in chronic hepatitis B patients non-responders to interferon therapy: a randomised clinical trial. , 2001, Journal of hepatology.

[5]  D. Treré,et al.  The asialoglycoprotein receptor in human hepatocellular carcinomas: its expression on proliferating cells , 1999, British Journal of Cancer.

[6]  D. Treré,et al.  Inhibition of [3H]thymidine incorporation into DNA of rat regenerating liver by 2',2'-difluorodeoxycytidine coupled to lactosaminated poly-L-lysine. , 1999, Biochemical pharmacology.

[7]  M. Monsigny,et al.  Optimized conditions to couple two water-soluble biomolecules through alkylamine thiolation and thioetherification. , 1999, Bioconjugate chemistry.

[8]  M. Brunetto,et al.  Adenine arabinoside monophosphate coupled to lactosaminated human albumin administered for 4 weeks in patients with chronic type B hepatitis decreased viremia without producing significant side effects , 1996, Hepatology.

[9]  P. Trail,et al.  (6-Maleimidocaproyl)hydrazone of doxorubicin--a new derivative for the preparation of immunoconjugates of doxorubicin. , 1993, Bioconjugate chemistry.

[10]  T. Kaneko,et al.  Evaluation in vitro of adriamycin immunoconjugates synthesized using an acid-sensitive hydrazone linker. , 1990, Cancer research.

[11]  L. Scarlett,et al.  Effect of galactose on interaction of N‐(2‐hydroxypropyl)methacrylamide copolymers with hepatoma cells in culture: Preliminary application to an anticancer agent, daunomycin , 1989, Hepatology.

[12]  M. Brunetto,et al.  INHIBITION OF HEPATITIS B VIRUS REPLICATION BY VIDARABINE MONOPHOSPHATE CONJUGATED WITH LACTOSAMINATED SERUM ALBUMIN , 1988, The Lancet.

[13]  L. Fiume,et al.  Drug targeting in antiviral chemotherapy. A chemically stable conjugate of 9-beta-D-arabinofuranosyl-adenine 5'-monophosphate with lactosaminated albumin accomplishes a selective delivery of the drug to liver cells. , 1986, Biochemical pharmacology.

[14]  Y. Schneider,et al.  Drug Targeting in Human Cancer Chemotherapy , 1984 .

[15]  G. Ashwell,et al.  Carbohydrate-specific receptors of the liver. , 1982, Annual review of biochemistry.

[16]  P. Balboni,et al.  Hepatocyte targeting of adenine‐9‐β‐D‐arabinofuranoside 5′‐monophosphate (ara‐AMP) coupled to lactosaminated albumin , 1981, FEBS letters.

[17]  J. D. de Vries,et al.  Selective inhibition of ectromelia virus DNA synthesis in hepatocytes by adenine‐9‐β‐D‐arabinofuranoside (ara‐A) and adenine‐9‐β‐D‐arabinofuranoside 5′‐monophosphate (ara‐AMP) conjugated to asialofetuin , 1980, FEBS letters.

[18]  M. Tognon,et al.  Enhanced inhibition of virus DNA synthesis in hepatocytes by trifluorothymidine coupled to asialofetuin , 1979, FEBS letters.

[19]  G. Wilson Effect of reductive lactosamination on the hepatic uptake of bovine pancreatic ribonuclease A dimer. , 1978, The Journal of biological chemistry.

[20]  K. Weber,et al.  The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. , 1969, The Journal of biological chemistry.

[21]  I. Sternlieb,et al.  Physical and chemical studies on ceruloplasmin. V. Metabolic studies on sialic acid-free ceruloplasmin in vivo. , 1968, The Journal of biological chemistry.

[22]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.