Effects of Storage Time on Quantitative and Qualitative Platelet Function after Transfusion

Background Platelet transfusions are being used increasingly in patients with thrombocytopenia to improve hemostatic function before surgery and invasive procedures. However, there are limited data on the immediate quantitative and qualitative platelet response after transfusion. Some authors have suggested that transfused platelets require time in vivo to regain maximal function, which is dependent on the duration of platelet storage. Therefore, the timing of surgery and invasive procedures with optimal platelet function may not be occurring.

[1]  J. White,et al.  Biochemistry, physiology, and function of platelets stored as concentrates , 1993, Transfusion.

[2]  C. Högman,et al.  Functional capacity of transfused platelets estimated by the Thrombostat 4000/2 , 1993, European journal of haematology.

[3]  J. AuBuchon,et al.  Effect of storage time on clinical efficacy of single‐donor platelet units , 1993, Transfusion.

[4]  W. Ouwehand,et al.  Guidelines for platelet transfusions , 1992 .

[5]  A. Chernoff,et al.  The cellular and molecular basis of the platelet storage lesion: a symposium summary , 1992, Transfusion.

[6]  S. Cardinali,et al.  Post‐transfusion recovery of function of 5‐day stored platelet concentrates , 1992, British journal of haematology.

[7]  R. Mohr,et al.  Fresh blood units contain large potent platelets that improve hemostasis after open heart operations. , 1992, The Annals of thoracic surgery.

[8]  B. Smith,et al.  Dynamics of leukocyte-platelet adhesion in whole blood , 1991 .

[9]  S. Slichter.  Platelet Transfusions a Constantly Evolving Therapy , 1991, Thrombosis and Haemostasis.

[10]  G. Escolar,et al.  Evaluation of the transfusion effectiveness of various platelet concentrates by means of an in vitro perfusion technique , 1991, Transfusion.

[11]  J. César,et al.  Arachidonic acid metabolism in platelets stored for 5 days , 1990, British journal of haematology.

[12]  L. Tarassenko,et al.  Platelet transfusion therapy: platelet concentrate preparation and storage. , 1988, The Journal of laboratory and clinical medicine.

[13]  J. Burch,et al.  Alterations in glutathione during storage of human platelet concentrates , 1987, Transfusion.

[14]  J. White,et al.  Interaction of long-term stored platelets with vascular subendothelium. , 1987, Journal of Laboratory and Clinical Medicine.

[15]  David T. Miller,et al.  Generation and Degradation of Fibrinopeptide A in Stored Platelet Concentrate , 1986, Vox sanguinis.

[16]  Edward J. Lee,et al.  Clinical evaluation of platelet concentrates stored for one to five days , 1986 .

[17]  J. White,et al.  Glutathione levels in human platelets display a circadian rhythm in vitro. , 1985, Thrombosis Research.

[18]  B. Savage.  Platelet adenine nucleotide levels during room‐temperature storage of platelet concentrates , 1982, Transfusion.

[19]  S. Murphy,et al.  Stored human platelets retain full aggregation potential in response to pairs of aggregating agents. , 1982, Blood.

[20]  J. Hirsh.  Platelet Age: its Relationship to Platelet Size, Function and Metabolism , 1972, British journal of haematology.

[21]  C. Valeri,et al.  Hemostatic effectiveness of platelets stored at 22 degrees C. , 1971, The New England journal of medicine.

[22]  F. Gardner,et al.  Platelet storage at 22 degrees C; metabolic, morphologic, and functional studies. , 1971, The Journal of clinical investigation.

[23]  S. Karpatkin.  Heterogeneity of human platelets. I. Metabolic and kinetic evidence suggestive of young and old platelets. , 1969, The Journal of clinical investigation.

[24]  C. Borchgrevink,et al.  The Role of Red Cells in Haemostasis: the Relation between Haematocrit, Bleeding Time and Platelet Adhesiveness , 1961, British journal of haematology.

[25]  G. Moroff,et al.  Concepts about current conditions for the preparation and storage of platelets. , 1991, Transfusion medicine reviews.