Volociximab, a chimeric integrin alpha5beta1 antibody, inhibits the growth of VX2 tumors in rabbits

[1]  D. Shaw,et al.  A non–RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo , 2006, Molecular Cancer Therapeutics.

[2]  G. Fuhrmann,et al.  The small α5β1 integrin antagonist, SJ749, reduces proliferation and clonogenicity of human astrocytoma cells , 2006 .

[3]  E. Ruoslahti,et al.  α5β1 integrin stimulates Bcl‐2 expression and cell survival through Akt, focal adhesion kinase, and Ca2+/calmodulin‐dependent protein kinase IV , 2005 .

[4]  I. Kasman,et al.  Rapid Access of Antibodies to α5β1 Integrin Overexpressed on the Luminal Surface of Tumor Blood Vessels , 2005 .

[5]  R. Ling,et al.  Lymphatic chemotherapy induces apoptosis in lymph node metastases in a rabbit breast carcinoma model , 2005, Journal of drug targeting.

[6]  J. Folkman,et al.  Fundamental concepts of the angiogenic process. , 2003, Current molecular medicine.

[7]  Raghu Kalluri,et al.  Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by αvβ3 and α5β1 integrins , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Semi Kim,et al.  Inhibition of endothelial cell survival and angiogenesis by protein kinase A. , 2002, The Journal of clinical investigation.

[9]  Richard O Hynes,et al.  Integrins Bidirectional, Allosteric Signaling Machines , 2002, Cell.

[10]  S. Saji,et al.  Antitumor Effects Induced by the Combination of TNP-470 as an Angiogenesis Inhibitor and Lentinan as a Biological Response Modifier in a Rabbit Spontaneous Liver Metastasis Model , 2002, Surgery Today.

[11]  M. Yi,et al.  A fibronectin fragment inhibits tumor growth, angiogenesis, and metastasis. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[12]  F. Sarkar,et al.  Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin. , 1995, The Journal of clinical investigation.

[13]  H. Taniguchi,et al.  Intra-arterial administration of the angiogenesis inhibitor TNP-470 blocks liver metastasis in a rabbit model. , 1995, British Journal of Cancer.

[14]  Bing Li,et al.  Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo , 1993, Nature.

[15]  L. Grochow,et al.  Intrathecal 4-hydroperoxycyclophosphamide: neurotoxicity, cerebrospinal fluid pharmacokinetics, and antitumor activity in a rabbit model of VX2 leptomeningeal carcinomatosis. , 1992, Cancer research.

[16]  P. Rous,et al.  EXPERIMENTS ON THE CAUSE OF THE RABBIT CARCINOMAS DERIVED FROM VIRUS-INDUCED PAPILLOMAS , 1952, The Journal of experimental medicine.

[17]  R. Dubridge,et al.  Preclinical evaluation of an anti-alpha5beta1 integrin antibody as a novel anti-angiogenic agent. , 2006, Journal of experimental therapeutics & oncology.

[18]  G. Fuhrmann,et al.  The small alpha5beta1 integrin antagonist, SJ749, reduces proliferation and clonogenicity of human astrocytoma cells. , 2006, Cancer research.

[19]  I. Kasman,et al.  Rapid access of antibodies to alpha5beta1 integrin overexpressed on the luminal surface of tumor blood vessels. , 2005, Cancer research.

[20]  E. Ruoslahti,et al.  alpha5beta1 integrin stimulates Bcl-2 expression and cell survival through Akt, focal adhesion kinase, and Ca2+/calmodulin-dependent protein kinase IV. , 2005, Journal of cellular biochemistry.

[21]  R. Kalluri,et al.  Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins. , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[22]  D. Taverna,et al.  The diverse roles of integrins and their ligands in angiogenesis. , 2002, Cold Spring Harbor symposia on quantitative biology.

[23]  E Ruoslahti,et al.  Integrin signaling. , 1999, Science.

[24]  D. Cheresh,et al.  Integrins, angiogenesis and vascular cell survival. , 1996, Chemistry & biology.