Recovery from aphasia and neglect after subcortical stroke: neuropsychological and cerebral perfusion study.

Cortical regional cerebral perfusion was assessed by N, N, N1-trimethyl-N1-(2)-hydroxy-3-methyl-5-(I-123) iodobenzyl-1, 3-propanediamine 2 HCl I-123 (HIPDM) and single photon emission computerised tomography (SPECT) in six aphasic and two neglect patients with unilateral subcortical vascular lesions. Assessments were carried out both in the acute phase and after a period ranging from 1 to 6 months after stroke onset. In all patients an almost complete spontaneous recovery occurred and was associated with a significant improvement of cortical perfusion. A relationship between severity of aphasia and degree of cortical hypoperfusion was found, in both the acute and the follow up assessments, in the aphasic subgroup.

[1]  C. Monakow,et al.  Die Lokalisation im Grosshirn und der Abbau der Funktion durch kortikale Herde , 1914 .

[2]  R. Kirk.  Experimental Design: Procedures for the Behavioral Sciences , 1970 .

[3]  A. Hirano,et al.  AN ATLAS OF THE HUMAN BRAIN FOR COMPUTERIZED TOMOGRAPHY. , 1978 .

[4]  A. Kertesz,et al.  Computer tomographic localization, lesion size, and prognosis in aphasia and nonverbal impairment , 1979, Brain and Language.

[5]  S. Cappa,et al.  “Transcortical” Features of Aphasia Following Left Thalamic Hemorrhage , 1979, Cortex.

[6]  F. Sakai,et al.  Case reports of three dysphasic patients to illustrate rCBF responses during behavioral activation , 1980, Brain and Language.

[7]  S. Cappa,et al.  Phonemic and lexical errors in fluent aphasia: Correlation with lesion site , 1981, Neuropsychologia.

[8]  B. Siesjö,et al.  Thresholds in cerebral ischemia - the ischemic penumbra. , 1981, Stroke.

[9]  A R Damasio,et al.  Aphasia with nonhemorrhagic lesions in the basal ganglia and internal capsule. , 1982, Archives of neurology.

[10]  S. Cappa,et al.  CT scan studies of aphasia. , 1983, Human neurobiology.

[11]  Daniel B Hier,et al.  Recovery of behavioral abnormalities after right hemisphere stroke , 1983, Neurology.

[12]  B. Crosson.  Role of the dominant thalamus in language: a review. , 1984, Psychological bulletin.

[13]  F. Fazio,et al.  Tomographic Assessment of Regional Cerebral Perfusion Using Intravenous 1–123 HIPDM and a Rotating Gamma Camera , 1984, Journal of computer assisted tomography.

[14]  D. Knopman,et al.  Mechanisms of recovery from aphasia: Evidence from serial xenon 133 cerebral blood flow studies , 1984, Annals of neurology.

[15]  G. Demeurisse,et al.  Prognostic value of computed tomography in aphasic stroke patients. , 1985, European neurology.

[16]  S Gilman,et al.  Basal ganglia glucose utilization after recent precentral ablation in the monkey , 1985, Annals of neurology.

[17]  M E Raichle,et al.  Positron emission tomography and its application to the study of cerebrovascular disease in man. , 1985, Stroke.

[18]  F. Fazio,et al.  Metabolic and Kinetic Considerations in the Use of [125I]HIPDM for Quantitative Measurement of Regional Cerebral Blood Flow , 1985, Journal of Cerebral Blood Flow and Metabolism.

[19]  J. Baron,et al.  Effects of thalamic stroke on energy metabolism of the cerebral cortex. A positron tomography study in man. , 1986, Brain : a journal of neurology.

[20]  J C Mazziotta,et al.  Left hemisphere intracerebral hemorrhages studied by (F‐18)‐fluorodeoxyglucose PET , 1986, Neurology.

[21]  T. Olsen,et al.  Cortical hypoperfusion as a possible cause of 'subcortical aphasia'. , 1986, Brain : a journal of neurology.

[22]  E. Metter.  Neuroanatomy and physiology of aphasia: Evidence from positron emission tomography , 1987 .

[23]  J. Penney,et al.  Experimental hemiplegia in the monkey: Basal ganglia glucose activity during recovery , 1987, Annals of neurology.

[24]  G. Demeurisse,et al.  Language recovery in aphasic stroke patients: Clinical, CT and CBF studies , 1987 .

[25]  Giuseppe Vallar,et al.  The Anatomy of Spatial Neglect in Humans , 1987 .

[26]  R. Deuel.  Neural Dysfunction During Hemineglect After Cortical Damage in Two Monkey Models , 1987 .

[27]  F Fazio,et al.  Aphasia and neglect after subcortical stroke. A clinical/cerebral perfusion correlation study. , 1987, Brain : a journal of neurology.

[28]  A. Alavi,et al.  Recovery of vision after ischemic lesions: Positron emission tomography , 1987, Annals of neurology.

[29]  M. Jeannerod.  Neurophysiological and neuropsychological aspects of spatial neglect. , 1987 .

[30]  S. Cappa,et al.  Latent dysphasia after left hemisphere lesions: A lexical–semantic and verbal memory deficit , 1988 .