Physiological effects of weightlessness: countermeasure system development for a long-term Chinese manned spaceflight

The Chinese space station will be built around 2020. As a national space laboratory, it will offer unique opportunities for studying the physiological effects of weightlessness and the efficacy of the countermeasures against such effects. In this paper, we described the development of countermeasure systems in the Chinese space program. To emphasize the need of the Chinese space program to implement its own program for developing countermeasures, we reviewed the literature on the negative physiological effects of weightlessness, the challenges of completing missions, the development of countermeasure devices, the establishment of countermeasure programs, and the efficacy of the countermeasure techniques in American and Russian manned spaceflights. In addition, a brief overview was provided on the Chinese research and development on countermeasures to discuss the current status and goals of the development of countermeasures against physiological problems associated with weightlessness.

[1]  Beth E. Lewandowski,et al.  Digital Astronaut Project Biomechanical Models: Biomechanical Modeling of Squat, Single-Leg Squat and Heel Raise Exercises on the Hybrid Ultimate Lifting Kit (HULK) , 2015 .

[2]  H. Genant,et al.  Cortical and Trabecular Bone Mineral Loss From the Spine and Hip in Long‐Duration Spaceflight , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[3]  Jacob J. Bloomberg,et al.  Integrated Resistance and Aerobic Training Study: Sprint , 2013 .

[4]  Carlos J. Reyes,et al.  Marked Exacerbation of Orthostatic Intolerance After Long- vs. Short-Duration Spaceflight in Veteran Astronauts , 2001, Psychosomatic medicine.

[5]  J. Hawley,et al.  Integrative Biology of Exercise , 2014, Cell.

[6]  K. Ohkawara,et al.  An exercise protocol designed to control energy expenditure for long-term space missions. , 2012, Aviation, space, and environmental medicine.

[7]  L. E. Warren,et al.  Long-duration head-down bed rest: project overview, vital signs, and fluid balance. , 2009, Aviation, space, and environmental medicine.

[8]  P. Cavanagh,et al.  Exercise and pharmacological countermeasures for bone loss during long-duration space flight. , 2005, Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology.

[9]  P. Cavanagh,et al.  Effects of Spaceflight and Skeletal Unloading on Bone Fracture Healing , 2012, Clinical Reviews in Bone and Mineral Metabolism.

[10]  Inessa B Kozlovskaya,et al.  Evolution of Russian Microgravity Countermeasures. , 2015, Aerospace medicine and human performance.

[11]  M. Bemben,et al.  Potential exercise countermeasures to attenuate skeletal muscle deterioration in space , 2011 .

[12]  Nahom M. Beyene.  The Art of Space Flight Exercise Hardware: Design and Implementation , 2004 .

[13]  K. Kirsch,et al.  Muscle and bone-aging and space. , 1999, Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology.

[14]  William H. Paloski,et al.  Artificial gravity as a countermeasure for mitigating physiological deconditioning during long-duration space missions , 2015, Front. Syst. Neurosci..

[15]  Patrick A. Willems,et al.  Biomechanical analysis of running in weightlessness on a treadmill equipped with a subject loading system , 2010, European Journal of Applied Physiology.

[16]  Pedro Arezes.  Advances in Safety Management and Human Factors , 2016 .

[17]  S. Schneider.  Exercise in space : a holistic approach for the benefit of human health on Earth , 2016 .

[18]  Peter R Cavanagh,et al.  Gravity replacement during running in simulated microgravity. , 2006, Aviation, space, and environmental medicine.

[19]  J G Chen,et al.  Exercise countermeasure protocol management expert system. , 1993, Computer methods and programs in biomedicine.

[20]  Scott M Smith,et al.  Effects of high-protein intake on bone turnover in long-term bed rest in women. , 2017, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[21]  James A. Loehr,et al.  Reliability of Strength Testing using the Advanced Resistive Exercise Device and Free Weights , 2008 .

[22]  R W Günther,et al.  Changes in calf muscle performance, energy metabolism, and muscle volume caused by long-term stay on space station MIR. , 1997, International journal of sports medicine.

[23]  Deborah W Korth,et al.  Exercise Countermeasure Hardware Evolution on ISS: The First Decade. , 2015, Aerospace medicine and human performance.

[24]  Dennis L. Carlson,et al.  Design of a resistive exercise device for use on the Space Shuttle , 1992 .

[25]  M. Yu. Belyaev,et al.  Microperturbations on the International Space Station during physical exercises of the crew , 2011 .

[26]  James E. Coolahan,et al.  Simulation of Integrated Physiology Based on an Astronaut Exercise Protocol , 2004 .

[27]  P Ullom-Minnich.  Prevention of osteoporosis and fractures. , 1999, American family physician.

[28]  Thomas G. Coleman,et al.  Development of the Digital Astronaut Project for the analysis of the mechanisms of physiologic adaptation to microgravity: Validation of the cardiovascular system module , 2008 .

[29]  Joachim Mester,et al.  Exercise in space: the European Space Agency approach to in-flight exercise countermeasures for long-duration missions on ISS , 2016, Extreme Physiology & Medicine.

[30]  J. Greenleaf,et al.  The exercise and environmental physiology of extravehicular activity. , 2002, Aviation, space, and environmental medicine.

[31]  K. Yamauchi,et al.  A countermeasure to ameliorate immune dysfunction in in vitro simulated microgravity environment: Role of cellular nucleotide nutrition , 2002, In Vitro Cellular & Developmental Biology - Animal.

[32]  Stefan Schneider,et al.  Exercise in Space , 2016, SpringerBriefs in Space Life Sciences.

[33]  Jason R. Bentley,et al.  Ground Reaction Force and Mechanical Differences Between the Interim Resistive Exercise Device (Ired) and Smith Machine While Performing a Squat , 2013 .

[34]  Richard A. Hagen,et al.  Development of the Vibration Isolation System for the Advanced Resistive Exercise Device , 2011 .

[35]  C. H. Evans,et al.  COMMITTEE ON STRATEGIES FOR SMALL-NUMBER-PARTICIPANT CLINICAL RESEARCH TRIALS , 2001 .

[36]  V A Convertino,et al.  Exercise countermeasures for spaceflight. , 1995, Acta astronautica.

[37]  William H. Paloski,et al.  Assessment of Countermeasure Efficacy for Long-Term Space Missions , 2000 .

[38]  Lori L. Ploutz-Snyder,et al.  Integrated Biomechanical Modeling of Lower Body Exercises on the Advanced Resistive Exercise Device (ARED) Using LifeMOD , 2014 .

[39]  Michael N. Sawka,et al.  ACSM's advanced exercise physiology , 2006 .

[40]  Christopher D. Lamoreaux,et al.  Mechanism Development, Testing, and Lessons Learned for the Advanced Resistive Exercise Device , 2006 .

[41]  P R Cavanagh,et al.  Foot forces during exercise on the International Space Station. , 2010, Journal of biomechanics.

[42]  L. Morin.  [Space physiology]. , 1961, Laval medical.

[43]  KYLE J. HACKNEY,et al.  The Astronaut-Athlete: Optimizing Human Performance in Space , 2015, Journal of strength and conditioning research.

[44]  Robert L. Hester,et al.  HumMod: A Modeling Environment for the Simulation of Integrative Human Physiology , 2011, Front. Physio..

[45]  W. Poston,et al.  Determining the amount of physical activity needed for long-term weight control , 2001, International Journal of Obesity.

[46]  J. Thonnard,et al.  Towards human exploration of space: the THESEUS review series on neurophysiology research priorities , 2016, npj Microgravity.

[47]  Alan R. Hargens,et al.  Intraocular and intracranial pressures during head-down tilt with lower body negative pressure. , 2015, Aerospace medicine and human performance.

[48]  William H Paloski,et al.  Medical monitoring during the NASA Artificial Gravity-Bed Rest Pilot Study. , 2007, Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology.

[49]  V A Convertino,et al.  Exercise as a countermeasure for physiological adaptation to prolonged spaceflight. , 1996, Medicine and science in sports and exercise.

[50]  Thomas J. Goodwin,et al.  Incorporation of omics analyses into artificial gravity research for space exploration countermeasure development , 2015, Metabolomics.

[51]  M. Custaud,et al.  Effect of Chinese herbal medicine on vascular functions during 60-day head-down bed rest , 2015, European Journal of Applied Physiology.

[52]  T. G. Coleman,et al.  Quantitative Circulatory Physiology: An integrative mathematical model of human physiology for medical education , 2007, Advances in physiology education.

[53]  Hiroshi Ohshima,et al.  Physical Training for Long-Duration Spaceflight. , 2015, Aerospace medicine and human performance.

[54]  P R Cavanagh,et al.  Foot forces during typical days on the international space station. , 2010, Journal of biomechanics.

[55]  Martina Heer,et al.  Space motion sickness: Incidence, etiology, and countermeasures , 2006, Autonomic Neuroscience.

[56]  J. Rittweger,et al.  Intracranial and Intraocular Pressure During Various Degrees of Head-Down Tilt. , 2017, Aerospace medicine and human performance.

[57]  Scott M Smith,et al.  Benefits for bone from resistance exercise and nutrition in long‐duration spaceflight: Evidence from biochemistry and densitometry , 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[58]  Alan H Feiveson,et al.  Peak exercise oxygen uptake during and following long-duration spaceflight. , 2014, Journal of applied physiology.

[59]  V. Convertino.  Consequences of cardiovascular adaptation to spaceflight: implications for the use of pharmacological countermeasures. , 2005, Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology.

[60]  Aasthaa Bansal,et al.  A harness for enhanced comfort and loading during treadmill exercise in space , 2013 .

[61]  P R Cavanagh,et al.  Evaluation of a Treadmill with Vibration Isolation and Stabilization (TVIS) for use on the International Space Station. , 1999, Journal of applied biomechanics.

[62]  Ronald J. White,et al.  A systems approach to the physiology of weightlessness , 2004, Journal of Medical Systems.

[63]  T. Lang,et al.  What do we know about fracture risk in long-duration spaceflight? , 2006, Journal of musculoskeletal & neuronal interactions.

[64]  A. V. Rao,et al.  Comparison of non-exercise test and step test in estimation of aerobic capacity (VO2max) in young adults - , 2014 .

[65]  E V Fomina,et al.  Russian Countermeasure Systems for Adverse Effects of Microgravity on Long-Duration ISS Flights. , 2015, Aerospace medicine and human performance.