Light-Emitting Diodes for Healthcare and Well-being

With the rapid development of semiconductors both in materials and technologies in recent years, LED has taken on a new look: higher luminous intensity, more stable peak wavelength, narrower half-wave bandwidth, better monochromaticity and orientation, and a nearly full coverage of the whole spectrum. In addition, LED devices are small in size, easy to operate and carry, and low in cost. They can be used to form complicated geometric figures so as to form point, line, and surface light sources and even flexible soft light source adaptable to the shape of a treatment area to realize evener illumination. For these reasons, LED light sources are now more and more popular in clinical practice. In this chapter, the mechanisms and indications of LED phototherapy and the status quo of the research on and development of LED phototherapy devices are introduced.

[1]  Michael R. Hamblin,et al.  Shining light on the head: Photobiomodulation for brain disorders , 2016, BBA clinical.

[2]  Defu Chen,et al.  Effects of pulse width and repetition rate of pulsed laser on kinetics and production of singlet oxygen luminescence , 2016 .

[3]  S. Umakanth,et al.  Closure of non-healing chronic ulcer in Klippel–Trenaunay syndrome using low-level laser therapy , 2012, BMJ Case Reports.

[4]  V. Bagnato,et al.  Comparison of Photodynamic Therapy versus conventional antifungal therapy for the treatment of denture stomatitis: a randomized clinical trial. , 2012, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[5]  E. Soh,et al.  Prevention of Thyroidectomy Scars in Asian Adults With Low-Level Light Therapy , 2016, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[6]  S. Campbell,et al.  Extraocular circadian phototransduction in humans. , 1998, Science.

[7]  Carla Bassanezi Mazzaro,et al.  [A prospective, randomized, open and comparative study to evaluate the safety and efficacy of blue light treatment versus a topical benzoyl peroxide 5% formulation in patients with acne grade II and III]. , 2009, Anais brasileiros de dermatologia.

[8]  N. Sadick.  A study to determine the effect of combination blue (415 nm) and near-infrared (830 nm) light-emitting diode (LED) therapy for moderate acne vulgaris , 2009, Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology.

[9]  Ling Zhu,et al.  The Mitochondrial Na+/Ca2+ Exchanger is Necessary but Not Sufficient for Ca2+ Homeostasis and Viability. , 2018, Advances in experimental medicine and biology.

[10]  Ying Gu,et al.  Twenty Years of Clinical Experience with a New Modality of Vascular‐Targeted Photodynamic Therapy for Port Wine Stains , 2011, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[11]  Won-Serk Kim,et al.  Is light-emitting diode phototherapy (LED-LLLT) really effective? , 2011, Laser therapy.

[12]  D. Barolet,et al.  Prophylactic low‐level light therapy for the treatment of hypertrophic scars and keloids: A case series , 2010, Lasers in surgery and medicine.

[13]  D. Xing,et al.  Intracellular signaling cascades following light irradiation , 2014 .

[14]  C. Enk,et al.  Low‐irradiance red LED traffic lamps as light source in PDT for actinic keratoses , 2012, Photodermatology, photoimmunology & photomedicine.

[15]  L. Rodrigues,et al.  Photodynamic antimicrobial chemotherapy and ultraconservative caries removal linked for management of deep caries lesions. , 2015, Photodiagnosis and photodynamic therapy.

[16]  Xiaodong Tan,et al.  The effects of low-intensity He-Ne laser irradiation on erythrocyte metabolism , 2015, Lasers in Medical Science.

[17]  V. Bagnato,et al.  Effects of photodynamic therapy with blue light and curcumin as mouth rinse for oral disinfection: a randomized controlled trial. , 2014, Photomedicine and laser surgery.

[18]  U. Schmidt-Erfurth,et al.  Mechanisms of action of photodynamic therapy with verteporfin for the treatment of age-related macular degeneration. , 2000, Survey of ophthalmology.

[19]  P. Peng,et al.  Microenvironment Dependent Photobiomodulation on Function-Specific Signal Transduction Pathways , 2014 .

[20]  T. Warloe,et al.  Guidelines for practical use of MAL‐PDT in non‐melanoma skin cancer , 2010, Journal of the European Academy of Dermatology and Venereology : JEADV.

[21]  M. Trelles,et al.  Er:YAG laser ablation of plantar verrucae with red LED therapy-assisted healing. , 2006, Photomedicine and laser surgery.

[22]  Walter W. Hauck,et al.  Light Therapy for Seasonal Affective Disorder with Blue Narrow-Band Light-Emitting Diodes (LEDs) , 2006, Biological Psychiatry.

[23]  Michael S Patterson,et al.  Characterization of Photofrin photobleaching for singlet oxygen dose estimation during photodynamic therapy of MLL cells in vitro , 2005, Physics in medicine and biology.

[24]  A. Deorari,et al.  Light-emitting diode phototherapy for unconjugated hyperbilirubinaemia in neonates. , 2011, The Cochrane database of systematic reviews.

[25]  Seung Yoon Lee,et al.  Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV , 2007, Lasers in surgery and medicine.

[26]  D. Nowis,et al.  PDT-induced inflammatory and host responses , 2011, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[27]  Shiqin Tao,et al.  Efficacy of 3.6% topical ALA-PDT for the treatment of severe acne vulgaris. , 2016, European review for medical and pharmacological sciences.

[28]  T. Sanderson,et al.  Phosphorylation of mammalian cytochrome c and cytochrome c oxidase in the regulation of cell destiny: respiration, apoptosis, and human disease. , 2012, Advances in experimental medicine and biology.

[29]  Tianhong Dai,et al.  The Nuts and Bolts of Low-level Laser (Light) Therapy , 2011, Annals of Biomedical Engineering.

[30]  Dong Hun Lee,et al.  Photodynamic therapy using chlorophyll-a in the treatment of acne vulgaris: a randomized, single-blind, split-face study. , 2014, Journal of the American Academy of Dermatology.

[31]  C. Leeuwenburgh,et al.  Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart. , 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

[32]  Ann-Marie Wennberg,et al.  Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. International Society for Photodynamic Therapy in Dermatology, 2005. , 2007, Journal of the American Academy of Dermatology.

[33]  T. C. Liu,et al.  Quantitative Biology of Exercise-Induced Signal Transduction Pathways. , 2017, Advances in experimental medicine and biology.

[34]  J. Hebling,et al.  Infrared LED irradiation photobiomodulation of oxidative stress in human dental pulp cells. , 2014, International endodontic journal.

[35]  Ying Gu,et al.  Vascular targeted photodynamic therapy for bleeding gastrointestinal mucosal vascular lesions: a preliminary study. , 2012, Photodiagnosis and photodynamic therapy.

[36]  Edward N Pugh,et al.  G proteins and phototransduction. , 2002, Annual review of physiology.

[37]  François A. Auger,et al.  Regulation of skin collagen metabolism in vitro using a pulsed 660 nm LED light source: clinical correlation with a single-blinded study. , 2009, The Journal of investigative dermatology.

[38]  Tiina I. Karu,et al.  The science of low-power laser therapy , 1998 .

[39]  R. Geronemus,et al.  Clinical trial of a novel non‐thermal LED array for reversal of photoaging: Clinical, histologic, and surface profilometric results , 2005, Lasers in surgery and medicine.

[40]  R. G. Calderhead,et al.  830 nm light-emitting diode (led) phototherapy significantly reduced return-to-play in injured university athletes: a pilot study. , 2016, Laser therapy.

[41]  G. D. Tanna,et al.  Light-activated disinfection using a light-emitting diode lamp in the red spectrum: clinical and microbiological short-term findings on periodontitis patients in maintenance. A randomized controlled split-mouth clinical trial , 2012, Lasers in Medical Science.

[42]  Michael R Hamblin,et al.  Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety , 2009, Behavioral and Brain Functions.

[43]  Fei Li,et al.  Low-Dose Topical 5-Aminolevulinic Acid Photodynamic Therapy in the Treatment of Different Severity of Acne Vulgaris , 2015, Cell Biochemistry and Biophysics.

[44]  Songhao Liu,et al.  Light-cell interaction: quasi-hormone model and time theory , 1996, Other Conferences.

[45]  R Duan,et al.  Signal transduction pathways involved in low intensity He–Ne laser‐induced respiratory burst in bovine neutrophils: A potential mechanism of low intensity laser biostimulation , 2001, Lasers in surgery and medicine.

[46]  B. Braeckman,et al.  Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2 , 2014, Proceedings of the National Academy of Sciences.

[47]  W. Cannon.  The Wisdom of the Body , 1932 .

[48]  Ross Zafonte,et al.  Significant improvements in cognitive performance post-transcranial, red/near-infrared light-emitting diode treatments in chronic, mild traumatic brain injury: open-protocol study. , 2014, Journal of neurotrauma.

[49]  P B Cerrito,et al.  The role of microvascular damage in photodynamic therapy: the effect of treatment on vessel constriction, permeability, and leukocyte adhesion. , 1992, Cancer Research.

[50]  Ki-Ho Park,et al.  A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings. , 2007, Journal of photochemistry and photobiology. B, Biology.

[51]  Nick Lane,et al.  Power games , 2006 .

[52]  Shiqin Tao,et al.  Low-dose topical 5-aminolevulinic acid photodynamic therapy in the treatment of different severity of acne vulgaris. , 2013, Photodiagnosis and photodynamic therapy.

[53]  M. Mohammadizadeh,et al.  Is the light-emitting diode a better light source than fluorescent tube for phototherapy of neonatal jaundice in preterm infants? , 2012, Advanced biomedical research.

[54]  H. Nawashiro,et al.  Focal increase in cerebral blood flow after treatment with near-infrared light to the forehead in a patient in a persistent vegetative state. , 2012, Photomedicine and laser surgery.

[55]  D. Goldberg,et al.  Combination blue (415 nm) and red (633 nm) LED phototherapy in the treatment of mild to severe acne vulgaris , 2006, Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology.

[56]  Zheng Huang,et al.  Topical ALA PDT for the treatment of severe acne vulgaris. , 2010, Photodiagnosis and photodynamic therapy.

[57]  R. Zângaro,et al.  The effects of transcranial LED therapy (TCLT) on cerebral blood flow in the elderly women , 2014, Lasers in Medical Science.

[58]  N. Puizina-Ivic,et al.  Single treatment of low-risk basal cell carcinomas with pulsed dye laser-mediated photodynamic therapy (PDL-PDT) compared with photodynamic therapy (PDT): A controlled, investigator-blinded, intra-individual prospective study. , 2016, Photodiagnosis and photodynamic therapy.

[59]  E. Wei,et al.  Photobiomodulation on Stress , 2012 .

[60]  R. Sutterfield.  Light therapy and advanced wound care for a neuropathic plantar ulcer on a Charcot foot. , 2008, Journal of wound, ostomy, and continence nursing : official publication of The Wound, Ostomy and Continence Nurses Society.

[61]  D. Stevenson,et al.  Phototherapy: current methods and future directions. , 2004, Seminars in perinatology.

[62]  Matthias Born,et al.  Prospective Randomized Long-Term Study on the Efficacy and Safety of UV-Free Blue Light for Treating Mild Psoriasis Vulgaris , 2015, Dermatology.

[63]  Raymond W Lam,et al.  A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD) , 2007, BMC psychiatry.

[64]  I D W Samuel,et al.  An open pilot study of ambulatory photodynamic therapy using a wearable low‐irradiance organic light‐emitting diode light source in the treatment of nonmelanoma skin cancer , 2009, The British journal of dermatology.

[65]  R. Geronemus,et al.  Topical methyl-aminolevulinate photodynamic therapy using red light-emitting diode light for treatment of multiple actinic keratoses: A randomized, double-blind, placebo-controlled study. , 2008, Journal of the American Academy of Dermatology.

[66]  Li-hong Liu,et al.  Randomized trial of three phototherapy methods for the treatment of acne vulgaris in Chinese patients , 2014, Photodermatology, photoimmunology & photomedicine.

[67]  Carla Bassanezi Mazzaro,et al.  Estudo clínico, prospectivo, aberto, randomizado e comparativo para avaliar a segurança e a eficácia da luz azul versus peróxido de benzoíla 5% no tratamento da acne inflamatória graus II e III , 2009 .

[68]  T. Demchak,et al.  Adjunctive use of combination of super-pulsed laser and light-emitting diodes phototherapy on nonspecific knee pain: double-blinded randomized placebo-controlled trial , 2014, Lasers in Medical Science.

[69]  S. Hekimi,et al.  The Intrinsic Apoptosis Pathway Mediates the Pro-Longevity Response to Mitochondrial ROS in C. elegans , 2014, Cell.

[70]  Hanli Liu,et al.  Interplay between up-regulation of cytochrome-c-oxidase and hemoglobin oxygenation induced by near-infrared laser , 2016, Scientific Reports.

[71]  D. Xing,et al.  Cancer phototherapy via selective photoinactivation of respiratory chain oxidase to trigger a fatal superoxide anion burst. , 2014, Antioxidants & redox signaling.