Maytansinoid-Antibody Conjugates Induce Mitotic Arrest by Suppressing Microtubule Dynamic Instability
暂无分享,去创建一个
E. Oroudjev | M. Jordan | L. Wilson | R. Chari | H. Erickson | M. Lopus | Y. Kovtun | Carmela A. Provenzano | C. Audette | Manu Lopus
[1] Jordan Ma,et al. Mechanism of action of antitumor drugs that interact with microtubules and tubulin. , 2012 .
[2] E. Oroudjev,et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules , 2010, Molecular Cancer Therapeutics.
[3] Suzanne F. Jones,et al. Phase I study of trastuzumab-DM1, an HER2 antibody-drug conjugate, given every 3 weeks to patients with HER2-positive metastatic breast cancer. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[4] E. K. Maloney,et al. Antibody-maytansinoid conjugates designed to bypass multidrug resistance. , 2010, Cancer Research.
[5] K. Singletary,et al. Suppression of microtubule dynamic instability and turnover in MCF7 breast cancer cells by sulforaphane. , 2008, Carcinogenesis.
[6] Franck Perez,et al. Detection of GTP-Tubulin Conformation in Vivo Reveals a Role for GTP Remnants in Microtubule Rescues , 2008, Science.
[7] John M Lambert,et al. Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate. , 2008, Cancer research.
[8] R. Chari. Targeted cancer therapy: conferring specificity to cytotoxic drugs. , 2008, Accounts of chemical research.
[9] M. Jordan,et al. How do microtubule-targeted drugs work? An overview. , 2007, Current cancer drug targets.
[10] V. Goldmacher,et al. Cell killing by antibody-drug conjugates. , 2007, Cancer letters.
[11] A. Tolcher,et al. Technology Insight: cytotoxic drug immunoconjugates for cancer therapy , 2007, Nature Clinical Practice Oncology.
[12] Alexander Staab,et al. A Phase I Dose Escalation Study with Anti-CD44v6 Bivatuzumab Mertansine in Patients with Incurable Squamous Cell Carcinoma of the Head and Neck or Esophagus , 2006, Clinical Cancer Research.
[13] G. Larson,et al. 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules , 2006, Molecular Cancer Therapeutics.
[14] Yelena Kovtun,et al. Semisynthetic maytansine analogues for the targeted treatment of cancer. , 2006, Journal of medicinal chemistry.
[15] R. Lutz,et al. Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing. , 2006, Cancer research.
[16] T. Chittenden,et al. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. , 2006, Cancer research.
[17] J. Lambert. Drug-conjugated monoclonal antibodies for the treatment of cancer. , 2005, Current opinion in pharmacology.
[18] Anna M Wu,et al. Arming antibodies: prospects and challenges for immunoconjugates , 2005, Nature Biotechnology.
[19] Suzanne V. Smith. Technology evaluation: huN901-DM1, ImmunoGen. , 2005, Current opinion in molecular therapeutics.
[20] R. Schilsky,et al. A Phase I Study of Cantuzumab Mertansine Administered as a Single Intravenous Infusion Once Weekly in Patients with Advanced Solid Tumors , 2004, Clinical Cancer Research.
[21] M. Jordan,et al. Microtubules as a target for anticancer drugs , 2004, Nature Reviews Cancer.
[22] Hongsheng Xie,et al. Pharmacokinetics and Biodistribution of the Antitumor Immunoconjugate, Cantuzumab Mertansine (huC242-DM1), and Its Two Components in Mice , 2004, Journal of Pharmacology and Experimental Therapeutics.
[23] M. Jordan,et al. Suppression of microtubule dynamics by epothilone B is associated with mitotic arrest. , 2003, Cancer research.
[24] A. Tolcher,et al. Cantuzumab mertansine, a maytansinoid immunoconjugate directed to the CanAg antigen: a phase I, pharmacokinetic, and biologic correlative study. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[25] L. Rebhun,et al. Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids. , 2002, Journal of medicinal chemistry.
[26] B. Hill,et al. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. , 2001, Molecular pharmacology.
[27] N. Kedersha,et al. Eradication of large colon tumor xenografts by targeted delivery of maytansinoids. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[28] M. Jordan,et al. Mechanism of inhibition of cell proliferation by Vinca alkaloids. , 1991, Cancer research.
[29] D. Scudiero,et al. New colorimetric cytotoxicity assay for anticancer-drug screening. , 1990, Journal of the National Cancer Institute.
[30] A. B. Huang,et al. Maytansine inhibits nucleotide binding at the exchangeable site of tubulin. , 1985, Biochemical and biophysical research communications.
[31] A. Verma,et al. The maytansinoids. Isolation, structural elucidation, and chemical interrelation of novel ansa macrolides. , 1977, The Journal of organic chemistry.
[32] B. Bhattacharyya,et al. Maytansine binding to the vinblastine sites of tubulin , 1977, FEBS letters.
[33] D. Johns,et al. Binding of maytansine to rat brain tubulin. , 1976, Biochemical and biophysical research communications.
[34] Adamson Rh,et al. Pharmacology of antitumor agents from higher plants. , 1976 .
[35] R. Adamson,et al. Experimental studies with maytansine--a new antitumor agent. , 1976, Bibliotheca haematologica.
[36] G A Howie,et al. Antimitotic activity of the potent tumor inhibitor maytansine. , 1975, Science.
[37] R. L. Dion,et al. Initial studies on maytansine-induced metaphase arrest in L1210 murine leukemia cells. , 1975, Biochemical pharmacology.
[38] C. Gilmore,et al. Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus. , 1972, Journal of the American Chemical Society.
[39] E. Oroudjev,et al. Determination of microtubule dynamic instability in living cells. , 2010, Methods in cell biology.
[40] Rajeeva Singh,et al. Tumor delivery and in vivo processing of disulfide-linked and thioether-linked antibody-maytansinoid conjugates. , 2010, Bioconjugate chemistry.
[41] M. Jordan,et al. Mechanism of action of antitumor drugs that interact with microtubules and tubulin. , 2002, Current medicinal chemistry. Anti-cancer agents.
[42] M. Jordan,et al. The use and action of drugs in analyzing mitosis. , 1999, Methods in cell biology.
[43] M. Jordan,et al. Use of drugs to study role of microtubule assembly dynamics in living cells. , 1998, Methods in enzymology.
[44] S. Shah,et al. Immunoconjugates containing novel maytansinoids: promising anticancer drugs. , 1992, Cancer research.
[45] R. Adamson,et al. Pharmacology of antitumor agents from higher plants. , 1976, Cancer treatment reports.