The Role of Human Orbitofrontal Cortex in Value Comparison for Incommensurable Objects

The human orbitofrontal cortex is strongly implicated in appetitive valuation. Whether its role extends to support comparative valuation necessary to explain probabilistic choice patterns for incommensurable goods is unknown. Using a binary choice paradigm, we derived the subjective values of different bundles of goods, under conditions of both gain and loss. We demonstrate that orbitofrontal activation reflects the difference in subjective value between available options, an effect evident across valuation for both gains and losses. In contrast, activation in dorsal striatum and supplementary motor areas reflects subjects' choice probabilities. These findings indicate that orbitofrontal cortex plays a pivotal role in valuation for incommensurable goods, a critical component process in human decision making.

[1]  A. Tversky,et al.  Prospect theory: analysis of decision under risk , 1979 .

[2]  G. E. Alexander,et al.  Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions. , 1990, Progress in brain research.

[3]  D. Kahneman,et al.  Anomalies: The Endowment Effect, Loss Aversion, and Status Quo Bias , 1991 .

[4]  P. Strick,et al.  Motor areas of the medial wall: a review of their location and functional activation. , 1996, Cerebral cortex.

[5]  O. Hikosaka,et al.  Expectation of reward modulates cognitive signals in the basal ganglia , 1998, Nature Neuroscience.

[6]  Michael L. Platt,et al.  Neural correlates of decision variables in parietal cortex , 1999, Nature.

[7]  Colin Camerer,et al.  Experience‐weighted Attraction Learning in Normal Form Games , 1999 .

[8]  W. Schultz,et al.  Relative reward preference in primate orbitofrontal cortex , 1999, Nature.

[9]  S. Chaiken,et al.  Personality and Social Psychology Bulle- Tin Chen, Bargh / Consequences of Automatic Evaluation Immediate Behavioral Predispositions to Approach or Avoid the Stimulus , 2022 .

[10]  Nir Vulkan.  An Economist's Perspective on Probability Matching , 2000 .

[11]  Nikolaus R. McFarland,et al.  Striatonigrostriatal Pathways in Primates Form an Ascending Spiral from the Shell to the Dorsolateral Striatum , 2000, The Journal of Neuroscience.

[12]  O. Hikosaka,et al.  A neural correlate of response bias in monkey caudate nucleus , 2002, Nature.

[13]  Sham M. Kakade,et al.  Opponent interactions between serotonin and dopamine , 2002, Neural Networks.

[14]  R Turner,et al.  Optimized EPI for fMRI studies of the orbitofrontal cortex , 2003, NeuroImage.

[15]  J. O'Doherty,et al.  Encoding Predictive Reward Value in Human Amygdala and Orbitofrontal Cortex , 2003, Science.

[16]  Okihide Hikosaka,et al.  Reward-Dependent Gain and Bias of Visual Responses in Primate Superior Colliculus , 2003, Neuron.

[17]  P. Glimcher,et al.  Activity in Posterior Parietal Cortex Is Correlated with the Relative Subjective Desirability of Action , 2004, Neuron.

[18]  W. Newsome,et al.  Matching Behavior and the Representation of Value in the Parietal Cortex , 2004, Science.

[19]  Jonathan D. Cohen,et al.  Conflict monitoring and anterior cingulate cortex: an update , 2004, Trends in Cognitive Sciences.

[20]  Jean-Baptiste Poline,et al.  Distinct striatal regions support movement selection, preparation and execution , 2004, Neuroreport.

[21]  Richard S. Sutton,et al.  Reinforcement Learning: An Introduction , 1998, IEEE Trans. Neural Networks.

[22]  H. Seung,et al.  JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR 2005, 84, 581–617 NUMBER 3(NOVEMBER) LINEAR-NONLINEAR-POISSON MODELS OF PRIMATE CHOICE DYNAMICS , 2022 .

[23]  M. E. Walton,et al.  Cognitive Neuroscience: Resolving Conflict in and over the Medial Frontal Cortex , 2005, Current Biology.

[24]  P. Glimcher,et al.  JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR 2005, 84, 555–579 NUMBER 3(NOVEMBER) DYNAMIC RESPONSE-BY-RESPONSE MODELS OF MATCHING BEHAVIOR IN RHESUS MONKEYS , 2022 .

[25]  Okihide Hikosaka,et al.  Functional differences between macaque prefrontal cortex and caudate nucleus during eye movements with and without reward , 2006, Experimental Brain Research.

[26]  S. Haber,et al.  Reward-Related Cortical Inputs Define a Large Striatal Region in Primates That Interface with Associative Cortical Connections, Providing a Substrate for Incentive-Based Learning , 2006, The Journal of Neuroscience.

[27]  C. Padoa-Schioppa,et al.  Neurons in the orbitofrontal cortex encode economic value , 2006, Nature.

[28]  J. O'Doherty,et al.  Predictive Neural Coding of Reward Preference Involves Dissociable Responses in Human Ventral Midbrain and Ventral Striatum , 2006, Neuron.

[29]  J. Hirsch,et al.  A Neural Representation of Categorization Uncertainty in the Human Brain , 2006, Neuron.

[30]  J. O'Doherty,et al.  Is Avoiding an Aversive Outcome Rewarding? Neural Substrates of Avoidance Learning in the Human Brain , 2006, PLoS biology.

[31]  P. Dayan,et al.  Cortical substrates for exploratory decisions in humans , 2006, Nature.

[32]  M. Walton,et al.  Separate neural pathways process different decision costs , 2006, Nature Neuroscience.

[33]  Kae Nakamura,et al.  Role of Dopamine in the Primate Caudate Nucleus in Reward Modulation of Saccades , 2006, The Journal of Neuroscience.

[34]  A. Pouget,et al.  Neural correlations, population coding and computation , 2006, Nature Reviews Neuroscience.

[35]  P. Dayan,et al.  Tonic dopamine: opportunity costs and the control of response vigor , 2007, Psychopharmacology.

[36]  A. Tversky,et al.  Prospect theory: an analysis of decision under risk — Source link , 2007 .

[37]  Timothy Edward John Behrens,et al.  Contrasting roles for cingulate and orbitofrontal cortex in decisions and social behaviour , 2007, Trends in Cognitive Sciences.

[38]  J. O'Doherty,et al.  Orbitofrontal Cortex Encodes Willingness to Pay in Everyday Economic Transactions , 2007, The Journal of Neuroscience.

[39]  Pavlo R. Blavatskyy,et al.  Stochastic Utility Theorem , 2007 .

[40]  G. Schoenbaum,et al.  Reconciling the Roles of Orbitofrontal Cortex in Reversal Learning and the Encoding of Outcome Expectancies , 2007, Annals of the New York Academy of Sciences.

[41]  G. Loewenstein,et al.  Neural Predictors of Purchases , 2007, Neuron.

[42]  Sabrina M. Tom,et al.  The Neural Basis of Loss Aversion in Decision-Making Under Risk , 2007, Science.

[43]  Masato Inoue,et al.  Neurons in the macaque orbitofrontal cortex code relative preference of both rewarding and aversive outcomes , 2007, Neuroscience Research.

[44]  P. Glimcher,et al.  The neural correlates of subjective value during intertemporal choice , 2007, Nature Neuroscience.

[45]  C. Padoa-Schioppa,et al.  The representation of economic value in the orbitofrontal cortex is invariant for changes of menu , 2008, Nature Neuroscience.

[46]  Samuel M. McClure,et al.  Anchors, scales and the relative coding of value in the brain , 2008, Current Opinion in Neurobiology.

[47]  Colin Camerer,et al.  Dissociating the Role of the Orbitofrontal Cortex and the Striatum in the Computation of Goal Values and Prediction Errors , 2008, The Journal of Neuroscience.

[48]  R. Elliott,et al.  Medial orbitofrontal cortex codes relative rather than absolute value of financial rewards in humans , 2008, The European journal of neuroscience.

[49]  N. Logothetis.  What we can do and what we cannot do with fMRI , 2008, Nature.

[50]  Timothy E. J. Behrens,et al.  Choice, uncertainty and value in prefrontal and cingulate cortex , 2008, Nature Neuroscience.

[51]  C. Kennard,et al.  Functional role of the supplementary and pre-supplementary motor areas , 2008, Nature Reviews Neuroscience.