Thalamocortical dysrhythmia syndrome: MEG imaging of neuropathic pain

Abnormal thalamocortical dynamics have been proposed as the underlying mechanism for a subset of neurological and psychiatric disorders that include centrally generated pain. Spectral analysis and independent component-based localization of neuromagnetic signals reveal ongoing theta-range activity localized to physiologically significant cortical regions in a group of subjects with well-characterized central and peripheral lesions. In addition, recordings from subjects who failed to obtain relief from spinal cord stimulation (SCS) and from those in whom SCS was successful further delineate thalamocortical dysrhythmias as a mechanism that underlies chronic pain.

[1]  A. Morel,et al.  Low-threshold calcium spike bursts in the human thalamus. Common physiopathology for sensory, motor and limbic positive symptoms. , 1996, Brain : a journal of neurology.

[2]  Bengt Långström,et al.  Somatotopic organization along the central sulcus, for pain localization in humans, as revealed by positron emission tomography , 1997, Experimental Brain Research.

[3]  G. Berríos.  Positive and negative symptoms and Jackson. A conceptual history. , 1985, Archives of general psychiatry.

[4]  M. Deschenes,et al.  The deafferented reticular thalamic nucleus generates spindle rhythmicity. , 1987, Journal of neurophysiology.

[5]  I F Gorodnitsky,et al.  Neuromagnetic source imaging with FOCUSS: a recursive weighted minimum norm algorithm. , 1995, Electroencephalography and clinical neurophysiology.

[6]  J R Moeller,et al.  Metabolic correlates of pallidal neuronal activity in Parkinson's disease. , 1997, Brain : a journal of neurology.

[7]  E. G. Jones,et al.  Viewpoint: the core and matrix of thalamic organization , 1998, Neuroscience.

[8]  W. Penfield.  The Excitable Cortex in Conscious Man , 1958 .

[9]  P. Wall,et al.  Pain mechanisms: a new theory. , 1965, Science.

[10]  P. Siddall,et al.  Thalamic neuronal activity in rats with mechanical allodynia following contusive spinal cord injury , 2003, Neuroscience.

[11]  Chronic neurogenic pain and the medial thalamotomy. , 1994, Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis.

[12]  Daniel Jeanmonod,et al.  Thalamocortical dysrhythmia II.: Clinical and surgical aspects , 2001 .

[13]  R. Llinás,et al.  Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[14]  R. Llinás,et al.  Temporal binding via cortical coincidence detection of specific and nonspecific thalamocortical inputs: A voltage-dependent dye-imaging study in mouse brain slices , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[15]  A. Benabid,et al.  Deep brain stimulation: what does it offer? , 2003, Advances in neurology.

[16]  Daniel Jeanmonod,et al.  Thalamocortical dysrhythmia I.: Functional and imaging aspects , 2001 .

[17]  K. D. Singh,et al.  Magnetic field tomography of coherent thalamocortical 40-Hz oscillations in humans. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[18]  A L Brody,et al.  Neuroimaging and frontal-subcortical circuitry in obsessive-compulsive disorder , 1998, British Journal of Psychiatry.

[19]  S Makeig,et al.  Blind separation of auditory event-related brain responses into independent components. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[20]  B. Connors,et al.  A network of electrically coupled interneurons drives synchronized inhibition in neocortex , 2000, Nature Neuroscience.

[21]  Tipu Z. Aziz,et al.  Motor cortex stimulation for chronic neuropathic pain: a preliminary study of 10 cases , 2000, Pain.

[22]  Y. Kanpolat,et al.  Percutaneous Controlled Radiofrequency Trigeminal Rhizotomy for the Treatment of Idiopathic Trigeminal Neuralgia: 25-year Experience with 1600 Patients , 1999, Neurosurgery.

[23]  R. Llinás,et al.  Human oscillatory brain activity near 40 Hz coexists with cognitive temporal binding. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[24]  E. Basar,et al.  Are cognitive processes manifested in event-related gamma, alpha, theta and delta oscillations in the EEG? , 1999, Neuroscience Letters.

[25]  R. Llinás.  The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. , 1988, Science.

[26]  D Albe-Fessard,et al.  Spontaneous neuronal hyperactivity in the medial and intralaminar thalamic nuclei of patients with deafferentation pain. , 1991, Journal of neurosurgery.

[27]  Thalamocortical dysrhythmia and the thalamic reticular nucleus in behaving rats , 2002, Clinical Neurophysiology.

[28]  J. Mäkelä,et al.  Modification of neuromagnetic cortical signals by thalamic infarctions. , 1998, Electroencephalography and clinical neurophysiology.

[29]  A. Morel,et al.  Thalamus and neurogenic pain: physiological, anatomical and clinical data. , 1993, Neuroreport.

[30]  Karen Faith Berman,et al.  Unilateral decrease in thalamic activity observed with positron emission tomography in patients with chronic neuropathic pain , 1995, Pain.

[31]  Ernst Fernando Lopes Da Silva Niedermeyer,et al.  Electroencephalography, basic principles, clinical applications, and related fields , 1982 .

[32]  W. Singer,et al.  Dynamic predictions: Oscillations and synchrony in top–down processing , 2001, Nature Reviews Neuroscience.

[33]  R. Portenoy,et al.  Pain management : theory and practice , 1996 .

[34]  P. Mitra,et al.  Analysis of dynamic brain imaging data. , 1998, Biophysical journal.

[35]  T Hirayama,et al.  Recordings of abnormal activity in patients with deafferentation and central pain. , 1989, Stereotactic and functional neurosurgery.

[36]  G. Holmes,et al.  Sensory disturbances from cerebral lesions , 1911 .

[37]  A. V. Apkarian,et al.  Brain chemistry reflects dual states of pain and anxiety in chronic low back pain , 2001, NeuroImage.

[38]  R. Llinás,et al.  The functional states of the thalamus and the associated neuronal interplay. , 1988, Physiological reviews.

[39]  L STAN LEUNG,et al.  Generation of Theta and Gamma Rhythms in the Hippocampus , 1998, Neuroscience & Biobehavioral Reviews.

[40]  R. Llinás,et al.  Neuropsychiatric thalamocortical dysrhythmia: surgical implications , 2003 .

[41]  T. Sejnowski,et al.  Thalamocortical oscillations in the sleeping and aroused brain. , 1993, Science.

[42]  F. Plum,et al.  Residual cerebral activity and behavioural fragments can remain in the persistently vegetative brain. , 2002, Brain : a journal of neurology.

[43]  H K Hartline,et al.  Visual receptors and retinal interaction. , 1969, Science.