Cellular polarity, mitotic synchrony and axes of symmetry during growth. Where does the information come from?

The polarization of cells during development is discussed with relationship to synchronized cell divisions and lineage restrictions. A tessellation model is proposed to explain the generation of the precise hexagonal array of ommatidia in the eye. This model allows the assembly of highly organized structures from localized cellular interactions. There is no requirement for a precise genetic description of the adult organism. Instead a sequential set of reiterated cellular interactions generates increasingly complex structures. The polarity patterns observed in adult cuticular bristles and hairs reflect accurate control of the shape of terminally differentiating cells rather than fine-grained positional information.

[1]  A. Garcı́a-Bellido.  Genetic control of wing disc development in Drosophila. , 2008, Ciba Foundation symposium.

[2]  D. Gubb,et al.  Drosophila tissue polarity requires the cell-autonomous activity of the fuzzy gene, which encodes a novel transmembrane protein. , 1997, Development.

[3]  S. Blair,et al.  Smoothened-mediated Hedgehog signalling is required for the maintenance of the anterior-posterior lineage restriction in the developing wing of Drosophila. , 1997, Development.

[4]  Konrad Basler,et al.  Control of compartmental affinity boundaries by Hedgehog , 1997, Nature.

[5]  S. Cambridge,et al.  Drosophila mitotic domain boundaries as cell fate boundaries. , 1997, Science.

[6]  P. Lawrence,et al.  Hedgehog acts by distinct gradient and signal relay mechanisms to organise cell type and cell polarity in the Drosophila abdomen. , 1997, Development.

[7]  P. Lawrence,et al.  Compartments, wingless and engrailed: patterning the ventral epidermis of Drosophila embryos. , 1996, Development.

[8]  R. Wepf,et al.  Roles for Rac1 and Cdc42 in planar polarization and hair outgrowth in the wing of Drosophila , 1996, The Journal of cell biology.

[9]  G. Struhl,et al.  Dual Roles for Patched in Sequestering and Transducing Hedgehog , 1996, Cell.

[10]  Jeremy Nathans,et al.  A new member of the frizzled family from Drosophila functions as a Wingless receptor , 1996, Nature.

[11]  Konrad Basler,et al.  Sending and Receiving the Hedgehog Signal: Control by the Drosophila Gli Protein Cubitus interruptus , 1996, Science.

[12]  S. Benzer,et al.  Independent determination of symmetry and polarity in the Drosophila eye. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[13]  P. Adler,et al.  The Drosophila tissue polarity gene inturned acts cell autonomously and encodes a novel protein. , 1996, Development.

[14]  P. Nurse,et al.  Fission yeast cell morphogenesis: identification of new genes and analysis of their role during the cell cycle , 1995, The Journal of cell biology.

[15]  U. Heberlein,et al.  Role of the morphogenetic furrow in establishing polarity in the Drosophila eye. , 1995, Development.

[16]  E. Sánchez-Herrero,et al.  The function of engrailed and the specification of Drosophila wing pattern. , 1995, Development.

[17]  J. Zhang,et al.  frizzled regulates mirror-symmetric pattern formation in the Drosophila eye. , 1995, Development.

[18]  K. Moses,et al.  Wingless and patched are negative regulators of the morphogenetic furrow and can affect tissue polarity in the developing Drosophila compound eye. , 1995, Development.

[19]  M. Wehrli,et al.  Epithelial planar polarity in the developing Drosophila eye. , 1995, Development.

[20]  G. Struhl,et al.  Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing. , 1995, Development.

[21]  S. Blair.  Compartments and appendage development in Drosophila , 1995, BioEssays : news and reviews in molecular, cellular and developmental biology.

[22]  D. Strutt,et al.  Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A , 1995, Nature.

[23]  T. J. Donohoe,et al.  Growth and differentiation in the Drosophila eye coordinated by hedgehog , 1995, Nature.

[24]  S. Benzer,et al.  Rotation of photoreceptor clusters in the developing drosophila eye requires the nemo gene , 1994, Cell.

[25]  H. Theisen,et al.  dishevelled is required during wingless signaling to establish both cell polarity and cell identity. , 1994, Development.

[26]  K. Moses,et al.  The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye , 1993, Cell.

[27]  Gerald M. Rubin,et al.  The TGFβ homolog dpp and the segment polarity gene hedgehog are required for propagation of a morphogenetic wave in the Drosophila retina , 1993, Cell.

[28]  D. Gubb.  Genes controlling cellular polarity in Drosophila. , 1993, Development (Cambridge, England). Supplement.

[29]  S. Cohen,et al.  Interaction between dorsal and ventral cells in the imaginal disc directs wing development in Drosophila , 1993, Cell.

[30]  P. Adler,et al.  Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells , 1993, The Journal of cell biology.

[31]  E. Wieschaus,et al.  Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos. , 1993, Development.

[32]  G. Rubin,et al.  Analysis of genetic mosaics in developing and adult Drosophila tissues. , 1993, Development.

[33]  M. Bate,et al.  A wingless-dependent polar coordinate system in Drosophila imaginal discs. , 1993, Science.

[34]  P. Adler.  The genetic control of tissue polarity in Drosophila , 1992, BioEssays : news and reviews in molecular, cellular and developmental biology.

[35]  P. Beachy,et al.  Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog , 1992, Cell.

[36]  T. Wolff,et al.  The beginning of pattern formation in the Drosophila compound eye: the morphogenetic furrow and the second mitotic wave. , 1991, Development.

[37]  A. Wilkins,et al.  Pattern formation in the embryo and imaginal discs of Drosophila: what are the links? , 1991, Developmental biology.

[38]  G. Odell,et al.  Mitotic Domains Partition Fly Embryos, Reflecting Early Cell Biological Consequences of Determination in Progress , 1989 .

[39]  V. Foe,et al.  Mitotic domains reveal early commitment of cells in Drosophila embryos. , 1989, Development.

[40]  P. Adler,et al.  A Drosophila tissue polarity locus encodes a protein containing seven potential transmembrane domains , 1989, Nature.

[41]  C. Nüsslein-Volhard,et al.  The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner , 1988, Cell.

[42]  N E Baker,et al.  Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo. , 1988, Development.

[43]  G. Rubin,et al.  Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of Drosophila , 1987, Cell.

[44]  Detlef Weigel,et al.  The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless , 1987, Cell.

[45]  D. Gubb,et al.  A genetic analysis of the determination of cuticular polarity during development in Drosophila melanogaster. , 1982, Journal of embryology and experimental morphology.

[46]  C. Nüsslein-Volhard,et al.  Mutations affecting segment number and polarity in Drosophila , 1980, Nature.

[47]  P. Simpson.  Parameters of cell competition in the compartments of the wing disc of Drosophila. , 1979, Developmental biology.

[48]  E. Lewis.  A gene complex controlling segmentation in Drosophila , 1978, Nature.

[49]  P. Lawrence,et al.  Compartments in the wing of Drosophila: a study of the engrailed gene. , 1976, Developmental biology.

[50]  F. Crick,et al.  Compartments and polyclones in insect development. , 1975, Science.

[51]  P. Lawrence,et al.  Control of compartment development by the engrailed gene in Drosophila , 1975, Nature.

[52]  P. Lawrence,et al.  The determination of polarity in the developing insect retina. , 1975, Journal of embryology and experimental morphology.

[53]  G. Morata,et al.  Developmental compartmentalisation of the wing disk of Drosophila. , 1973, Nature: New biology.

[54]  R. Greenberg.  Biometry , 1969, The Yale Journal of Biology and Medicine.

[55]  J. Howe.  New Member , 1951, The Bulletin of the Ecological Society of America.

[56]  J. Celis.  Positioning and differentiation of veins in the Drosophila wing , 1998 .

[57]  J. D. de Celis.  Positioning and differentiation of veins in the Drosophila wing. , 1998, The International journal of developmental biology.

[58]  C. Pillinger,et al.  A New Member of the , 1995 .

[59]  J. O'Leary.  Sending and receiving , 1993 .

[60]  S. Zipursky,et al.  Induction of the R7 neuron in the Drosophila compound eye: the bride of sevenless and sevenless interaction. , 1992, Cold Spring Harbor symposia on quantitative biology.

[61]  A. Wilkins.  Genetic analysis of animal development , 1986 .

[62]  W. McGinnis,et al.  Isolation of a homoeo box-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcripts , 1985, Nature.

[63]  S. Bryant,et al.  Pattern Formation: A Primer in Developmental Biology , 1984 .

[64]  A. Turing.  On Computable Numbers, with an Application to the Entscheidungsproblem. , 1937 .