Considerations and caveats in anti-virulence drug development.
暂无分享,去创建一个
[1] R. Platt,et al. Surgical Site Infections , 2016, Medical care.
[2] Sang-Bum Hong,et al. Sepsis and Acute Respiratory Distress Syndrome: Recent Update , 2016, Tuberculosis and respiratory diseases.
[3] S. Nathan,et al. Targeting Staphylococcus aureus Toxins: A Potential form of Anti-Virulence Therapy , 2016, Toxins.
[4] R. Hartmann,et al. Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections. , 2016, Journal of medicinal chemistry.
[5] David W Bates,et al. Integrating Predictive Analytics Into High-Value Care: The Dawn of Precision Delivery. , 2016, JAMA.
[6] I. Henderson,et al. Alternatives to antibiotics-a pipeline portfolio review. , 2016, The Lancet. Infectious diseases.
[7] H. Xiang,et al. The therapeutic effect of chlorogenic acid against Staphylococcus aureus infection through sortase A inhibition , 2015, Front. Microbiol..
[8] L. Popa,et al. Microbial biofilms: impact on the pathogenesis of periodontitis, cystic fibrosis, chronic wounds and medical device-related infections. , 2015, Current topics in medicinal chemistry.
[9] Yue Zheng,et al. Agents that inhibit bacterial biofilm formation. , 2015, Future medicinal chemistry.
[10] Alexander A. Morgan,et al. Prediction of multiple infections after severe burn trauma: a prospective cohort study. , 2015, Annals of surgery.
[11] X. Zhou,et al. Morin hydrate attenuates Staphylococcus aureus virulence by inhibiting the self‐assembly of α‐hemolysin , 2015, Journal of applied microbiology.
[12] Yonatan H. Grad,et al. Origin and Proliferation of Multiple-Drug Resistance in Bacterial Pathogens , 2015, Microbiology and Molecular Reviews.
[13] R. Hartmann,et al. Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD. , 2015, European journal of medicinal chemistry.
[14] Wai-Fong Yin,et al. Non-antibiotic quorum sensing inhibitors acting against N-acyl homoserine lactone synthase as druggable target , 2014, Scientific Reports.
[15] M. Fröhlich,et al. Evaluation of the Toxicity of 5-Aryl-2-Aminoimidazole-Based Biofilm Inhibitors against Eukaryotic Cell Lines, Bone Cells and the Nematode Caenorhabditis elegans , 2014, Molecules.
[16] Jasmine Lee,et al. The hierarchy quorum sensing network in Pseudomonas aeruginosa , 2014, Protein & Cell.
[17] S. de Bentzmann,et al. Characterization of a novel two-partner secretion system implicated in the virulence of Pseudomonas aeruginosa. , 2014, Microbiology.
[18] H. Blackwell,et al. Competition Studies Confirm Two Major Barriers That Can Preclude the Spread of Resistance to Quorum-Sensing Inhibitors in Bacteria , 2014, ACS chemical biology.
[19] A. Tzika,et al. Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity , 2014, PLoS pathogens.
[20] Jintae Lee,et al. Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus , 2014, Applied Microbiology and Biotechnology.
[21] B. Sellman,et al. A Novel Anti-PcrV Antibody Providing Enhanced Protection against Pseudomonas aeruginosa in Multiple Animal Infection Models , 2014, Antimicrobial Agents and Chemotherapy.
[22] Stephen P. Diggle,et al. Targeting virulence: can we make evolution-proof drugs? , 2014, Nature Reviews Microbiology.
[23] W. Chan,et al. Targeting Staphylococcus aureus Quorum Sensing with Nonpeptidic Small Molecule Inhibitors , 2014, Journal of medicinal chemistry.
[24] Sam P. Brown,et al. Gallium-mediated siderophore quenching as an evolutionarily robust antibacterial treatment , 2014, Evolution, medicine, and public health.
[25] Ori J. Lieberman,et al. High-throughput screening using the differential radial capillary action of ligand assay identifies ebselen as an inhibitor of diguanylate cyclases. , 2014, ACS chemical biology.
[26] Richard D. Smith,et al. Activated ClpP kills persisters and eradicates a chronic biofilm infection , 2013, Nature.
[27] Knut Drescher,et al. A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation , 2013, Proceedings of the National Academy of Sciences.
[28] T. Wood,et al. Resistance to Quorum-Quenching Compounds , 2013, Applied and Environmental Microbiology.
[29] J. Engel,et al. Sugar administration is an effective adjunctive therapy in the treatment of Pseudomonas aeruginosa pneumonia. , 2013, American journal of physiology. Lung cellular and molecular physiology.
[30] P. Williams,et al. Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR) , 2013, PLoS pathogens.
[31] Michael Y. Galperin,et al. Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger , 2013, Microbiology and Molecular Reviews.
[32] Brendan F Gilmore,et al. Clinical relevance of the ESKAPE pathogens , 2013, Expert review of anti-infective therapy.
[33] R. Tompkins,et al. The Quorum Sensing Volatile Molecule 2-Amino Acetophenon Modulates Host Immune Responses in a Manner that Promotes Life with Unwanted Guests , 2012, PLoS pathogens.
[34] Michael P. Storz,et al. Validation of PqsD as an anti-biofilm target in Pseudomonas aeruginosa by development of small-molecule inhibitors. , 2012, Journal of the American Chemical Society.
[35] A. Mebazaa,et al. Safety and pharmacokinetics of an anti-PcrV PEGylated monoclonal antibody fragment in mechanically ventilated patients colonized with Pseudomonas aeruginosa: A randomized,double-blind, placebo-controlled trial* , 2012, Critical care medicine.
[36] R. Morona,et al. Chemical Inhibition of Bacterial Protein Tyrosine Phosphatase Suppresses Capsule Production , 2012, PloS one.
[37] J. Colmer-Hamood,et al. Garlic ointment inhibits biofilm formation by bacterial pathogens from burn wounds. , 2012, Journal of medical microbiology.
[38] Ozlem Sandikci,et al. [Factors associated with mortality in Acinetobacter baumannii infected intensive care unit patients]. , 2012, Mikrobiyoloji Bulteni.
[39] L. Rahme,et al. Honey’s Ability to Counter Bacterial Infections Arises from Both Bactericidal Compounds and QS Inhibition , 2012, Front. Microbio..
[40] Martin Schuster,et al. The Sociomicrobiology of Antivirulence Drug Resistance: a Proof of Concept , 2011, mBio.
[41] L. Garcia,et al. Quorum quenching quandary: resistance to antivirulence compounds , 2011, The ISME Journal.
[42] L. Rahme,et al. A Quorum Sensing Regulated Small Volatile Molecule Reduces Acute Virulence and Promotes Chronic Infection Phenotypes , 2011, PLoS pathogens.
[43] Richard A. Moore,et al. Development and Application of a Cellular, Gain-of-Signal, Bioluminescent Reporter Screen for Inhibitors of Type II Secretion in Pseudomonas aeruginosa and Burkholderia pseudomallei , 2011, Journal of biomolecular screening.
[44] R. Hartmann,et al. Biosynthesis of 2‐Alkyl‐4(1H)‐Quinolones in Pseudomonas aeruginosa: Potential for Therapeutic Interference with Pathogenicity , 2011, Chembiochem : a European journal of chemical biology.
[45] Haihua Feng,et al. Menthol diminishes Staphylococcus aureus virulence-associated extracellular proteins expression , 2011, Applied Microbiology and Biotechnology.
[46] H. Ceri,et al. Needed, new paradigms in antibiotic development , 2010, Expert opinion on pharmacotherapy.
[47] A. Hauser. The type III secretion system of Pseudomonas aeruginosa: infection by injection , 2009, Nature Reviews Microbiology.
[48] V. Nizet,et al. Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results. , 2009, Journal of medicinal chemistry.
[49] C. Melander,et al. Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates. , 2009, Organic & biomolecular chemistry.
[50] D. Mack,et al. Inhalation with Fucose and Galactose for Treatment of Pseudomonas Aeruginosa in Cystic Fibrosis Patients , 2008, International journal of medical sciences.
[51] Samuel I. Miller,et al. An inhibitor of gram-negative bacterial virulence protein secretion. , 2008, Cell host & microbe.
[52] C. Melander,et al. Construction and screening of a 2-aminoimidazole library identifies a small molecule capable of inhibiting and dispersing bacterial biofilms across order, class, and phylum. , 2008, Angewandte Chemie.
[53] H. Boucher,et al. Epidemiology of methicillin-resistant Staphylococcus aureus. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
[54] Atlanta,et al. Invasive Methicillin-Resistant Staphylococcus aureus Infections in the United States , 2007 .
[55] R. Tompkins,et al. Inhibitors of Pathogen Intercellular Signals as Selective Anti-Infective Compounds , 2007, PLoS pathogens.
[56] P. Cosson,et al. Inhibitors of bacterial virulence identified in a surrogate host model , 2007, Cellular microbiology.
[57] T. Liljefors,et al. The LuxR receptor: the sites of interaction with quorum-sensing signals and inhibitors. , 2005, Microbiology.
[58] C. Hughes,et al. Of Mice and Not Men: Differences between Mouse and Human Immunology , 2004, The Journal of Immunology.
[59] M. Oh,et al. Pseudomonas aeruginosa bacteremia: risk factors for mortality and influence of delayed receipt of effective antimicrobial therapy on clinical outcome. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
[60] S. Kjelleberg,et al. Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors , 2003, The EMBO journal.
[61] Michael S. Gilmore,et al. Modulation of virulence within a pathogenicity island in vancomycin-resistant Enterococcus faecalis , 2002, Nature.
[62] R. Irvin,et al. Interaction between the pili of Pseudomonas aeruginosa PAK and its carbohydrate receptor β-D-GalNAc(1->4) β-D-Gal analogs , 1998 .
[63] H. Hang,et al. Small molecules aimed at type III secretion systems to inhibit bacterial virulence. , 2013, MedChemComm.
[64] M. Bottomley,et al. Covalent inhibition of bacterial quorum sensing. , 2009, Journal of the American Chemical Society.
[65] N. Siafakas,et al. Risk-factors and predictors of mortality in patients colonised with vancomycin-resistant enterococci. , 2008, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
[66] V. Nizet,et al. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. , 2008, Science.
[67] R. Irvin,et al. Interaction between the pili of Pseudomonas aeruginosa PAK and its carbohydrate receptor beta-D-GalNAc(1-->4)beta-D-Gal analogs. , 1998, Canadian Journal of Microbiology (print).