Immunogenetic and Biological Aspects of in Vitro Lymphocyte Allotransformation (MLR) in the Mouse

When small lymphocytes from pairs of unrelated individuals are mixed and cultured together for several days, they are mutually stimulated and transform into DNA synthesizing blast cells capable of division. This phenomenon has been termed the Mixed Lymphocyte Reaction (MLR) and the test, the Mixed Lymphocyte Culture (MLC) test. The suggestion that MLR had a genetic basis arose from the human MLC experiments (Bain et al. 1963, Bain & Lowenstein 1964, Bach & Hirschhorn 1964) who showed that, on average, cells in MLC from pairs of unrelated individuals were more highly stimulated than those from sibling pairs, whilst lymphocytes from identical twins failed completely to react.

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