Speculations Concerning Present and Future Developments In Indicator‐Dilution Technics

• Speculations to be of appreciable value should be based on (1) thorough knowledge of the past and (2) as realistic as possible prediction of the needs of the future. Then from a knowledge of these two factors, perhaps an educated guess can be made as to how the developments and capabilities from the past up to the present may be extended and synthesized with the needs of the future in order to fulfill these needs. The past aspects of indicator-dilution technics are well covered by Fox in another section of this symposium and will not be touched on further here. The remainder of this discussion therefore will be concerned with present and future developments. All past and future developments are determined by two factors: (1) the development of completely new concepts or the variation of old concepts based on known or newly discovered information and (2) the availability or adaptation of technics and instrumentation to obtain the data required to test and utilize these concepts. Discussion will be carried out along the lines of these two considerations. It is a truism that the development of a really new concept is indeed a very rare occurrence ; obviously, therefore, no really new concepts will be covered in this presentation. The development of new technics and instrumentation, like the development of new concepts, is actually nearly always the further development, adaptation or refinement of previous technics and instrumentation. Such new developments occur with a much greater frequency than do the development of new

[1]  A. W. Edwards,et al.  Blood level of indocyanine green in the dog during multiple dye curves and its effect on instrumental calibration. , 1960, Proceedings of the staff meetings. Mayo Clinic.

[2]  E. Wood,et al.  Hemodynamic methods for differentiation of mitral stenosis and regurgitation. , 1958, The American journal of cardiology.

[3]  E. Wood,et al.  Apparent dye-dilution curves produced by injection of transparent solutions , 1961 .

[4]  E. Wood,et al.  Dynamic response characteristics of systems for continuous recording of concentration changes in a flowing liquid (for example, indicator-dilution curves). , 1957, Journal of applied physiology.

[5]  E. Wood,et al.  O2 content of mixed venous blood in man during various phases of the respiratory and cardiac cycles in relation to possible errors in measurement of cardiac output by conventional application of the Fick method. , 1955, Journal of applied physiology.

[6]  E. Rapaport,et al.  Some Theoretical Aspects of Quantification of Mitral Valve Regurgitation by the Indicator‐Dilution Method: Sufficient and Insufficient Experiments , 1961, Circulation research.

[7]  D. F. Rochester,et al.  Estimation of pulmonary arteriovenous shunt-flow using intravenous injections of T-1824 dye and Kr85. , 1960, The Journal of clinical investigation.

[8]  M. Prinzmetal CALCULATION OF THE VENOUS-ARTERIAL SHUNT IN CONGENITAL HEART DISEASE. , 1941, The Journal of clinical investigation.

[9]  H. Warner Analysis of the Role of Indicator Technics In Quantitation of Valvular Regurgitation , 1962, Circulation research.

[10]  K. Hosie Thermal‐Dilution Technics , 1962, Circulation research.

[11]  L. C. Clark,et al.  Left-to-Right Shunt Detection by an Intravascular Electrode with Hydrogen as an Indicator , 1959, Science.

[12]  A. W. Edwards,et al.  Areas of dye-dilution curves sampled simultaneously from central and peripheral sites. , 1962, Journal of applied physiology.

[13]  J. P. Holt,et al.  Estimation of the Residual Volume of the Ventricle of the Dog's Heart by Two Indicator Dilution Technics , 1956, Circulation research.

[14]  C. Newcombe,et al.  Detection and Assessment of Mitral Regurgitation by Left Atrial Indicator‐Dilution Curves , 1961, Circulation research.

[15]  Robert E. Kalaba,et al.  The distribution of a drug in the body. , 1960 .

[16]  I. J. Fox Indicators and Detectors in Circulatory Dilution Studies and Their Application to Organ or Regional Blood‐flow Determination , 1962, Circulation research.

[17]  I. J. Fox History and Developmental Aspects of The Indicator‐Dilution Technic , 1962, Circulation research.

[18]  W. Sutterer,et al.  A compensated dichromatic densitometer for indocyanine green. , 1962, IRE transactions on bio-medical electronics.

[19]  F. Grodins,et al.  Basic Concepts in the Determination of vascular Volumes by Indicator‐Dilution Methods , 1962, Circulation research.

[20]  L. C. Clark Intravascular polarographic and potentiometric electrodes for the study of circulation. , 1960, Transactions - American Society for Artificial Internal Organs.

[21]  F. Chinard,et al.  Indicator‐Dilution Studies with “Diffusible” Indicators , 1962, Circulation research.

[22]  E H WOOD,et al.  Diagnostic Applications of Indicator‐Dilution Technics In Congenital Heart Disease , 1962, Circulation research.

[23]  W. Hitzig,et al.  The Diagnosis of Venous-arterial Shunt by Ether Circulation Time Method , 1938 .

[24]  E. Wood,et al.  Method for simultaneous measurement of total and lower-body blood flow using indicator-dilution technics. , 1960, Proceedings of the staff meetings. Mayo Clinic.