Topical Ankaferd hemostat application for the management of oral cavity bleedings in children with hemorrhagic diathesis

Ankaferd blood stopper (ABS) is a hemostatic agent used topically for controlling bleedings of skin or mucosal surfaces in Turkey. It is currently topically used in bleedings of body injuries, traumas, and minor or major surgical interventions. Here we have evaluated 12 pediatric patients with hemorrhagic diathesis on whom Ankaferd was used for oral bleedings. Topical Ankaferd was administered for hemorrhages of oral cavity during 15 bleeding attacks. ABS administrations successfully stopped the bleedings, except for one patient with oral hemorrhage who did not respond to ABS application. Ankaferd is effective for oral bleedings of children with bleeding diathesis especially when other measures have failed.

[1]  E. Yilmaz,et al.  Reversible Protease-Activated Receptor 1 Downregulation Mediated by Ankaferd Blood Stopper Inducible With Lipopolysaccharides Inside the Human Umbilical Vein Endothelial Cells , 2011, Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.

[2]  M. Dogan,et al.  New Coagulant Agent (Ankaferd Blood Stopper) for Open Hemorrhages in Hemophilia With Inhibitor , 2010, Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.

[3]  A. Karaman,et al.  Efficacy of Ankaferd Blood Stopper in postpolypectomy bleeding. , 2010, Journal of alternative and complementary medicine.

[4]  N. Yaralı,et al.  A NEW HEMOSTATIC AGENT—ANKAFERD BLOOD STOPPER: MANAGEMENT OF GASTROINTESTINAL BLEEDING IN AN INFANT AND OTHER EXPERIENCES IN CHILDREN , 2010, Pediatric hematology and oncology.

[5]  I. Haznedaroglu,et al.  An alternative hemostatic method for early GI bleeding caused by anastomotic ulcer. , 2010, Gastrointestinal endoscopy.

[6]  I. Haznedaroglu,et al.  No prolonged effect of Ankaferd Blood Stopper on chronic radiation proctitis. , 2010, Endoscopy.

[7]  A. Yıldız,et al.  Bleeding due to slippage of elastic band during variceal ligation: successful use of Ankaferd blood stopper , 2010, Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology.

[8]  E. Huri,et al.  First Clinical Experience of Ankaferd BloodStopper as a Hemostatic Agent in Partial Nephrectomy , 2010, The Kaohsiung journal of medical sciences.

[9]  I. Haznedaroglu,et al.  A new practical alternative for tumoural gastrointestinal bleeding: Ankaferd blood stopper. , 2010, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[10]  B. Haznedaroglu,et al.  Ultrastructural and Morphological Analyses of the In Vitro and In Vivo Hemostatic Effects of Ankaferd Blood Stopper , 2010, Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.

[11]  E. Huri,et al.  Biphasic effects of ankaferd blood stopper on renal tubular apoptosis in the rat partial nephrectomy model representing distinct levels of hemorrhage. , 2010, Saudi medical journal.

[12]  S. Işler,et al.  Effects of folk medicinal plant extract Ankaferd Blood Stopper® on early bone healing , 2010, Journal of applied oral science : revista FOB.

[13]  N. Akar,et al.  Functional proteomic analysis of Ankaferd® Blood Stopper. , 2010, Turkish journal of haematology : official journal of Turkish Society of Haematology.

[14]  M. Kurt,et al.  Ankaferd Blood Stopper for controlling gastrointestinal bleeding due to distinct benign lesions refractory to conventional antihemorrhagic measures. , 2010, Canadian journal of gastroenterology = Journal canadien de gastroenterologie.

[15]  M. Kurt,et al.  Topical Ankaferd Application to Presacral Bleeding due to Total Mesorectal Excision in Rectal Carcinoma , 2010, Journal of investigative surgery : the official journal of the Academy of Surgical Research.

[16]  E. Baltacıoğlu,et al.  The use of Ankaferd blood stopper in a patient with Glanzmann's thrombasthenia with gingival bleeding. , 2010, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[17]  L. Doğanay,et al.  Instant control of fundal variceal bleeding with a folkloric medicinal plant extract: Ankaferd Blood Stopper. , 2010, Gastrointestinal endoscopy.

[18]  S. Aksu,et al.  Endoscopic topical application of Ankaferd Blood Stopper for neoplastic gastrointestinal bleeding: A retrospective analysis. , 2010, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[19]  I. Haznedaroglu,et al.  The effect of a new hemostatic agent for difficult cases of non-variceal gastrointestinal bleeding: Ankaferd blood stopper. , 2010, Hepato-gastroenterology.

[20]  M. Kurt,et al.  Safety and Efficacy of Ankaferd Blood Stopper in Dental Surgery , 2010 .

[21]  V. Kahya,et al.  Prospective, randomized, controlled clinical trial of Ankaferd Blood Stopper in patients with acute anterior epistaxis , 2010, European Archives of Oto-Rhino-Laryngology.

[22]  G. Hasçelik,et al.  Antimicrobial activity of Ankaferd Blood Stopper® against nosocomial bacterial pathogens , 2010 .

[23]  T. Baykul,et al.  Use of Ankaferd Blood Stopper as a hemostatic agent: a clinical experience. , 2010, The journal of contemporary dental practice.

[24]  V. Kahya,et al.  Prospective, controlled clinical trial of Ankaferd Blood Stopper in children undergoing tonsillectomy. , 2009, International journal of pediatric otorhinolaryngology.

[25]  N. Turhan,et al.  Topical Ankaferd Blood Stopper Administration to Bleeding Gastrointestinal Carcinomas Decreases Tumor Vascularization , 2009, The American Journal of Gastroenterology.

[26]  I. Haznedaroglu,et al.  The effect of Ankaferd blood stopper on severe radiation colitis. , 2009, Endoscopy.

[27]  C. Germiyanoğlu,et al.  Hemostasis in Retropubic Radical Prostatectomy with Ankaferd BloodStopper®: A Case Report , 2009, The Kaohsiung journal of medical sciences.

[28]  S. Aksu,et al.  In vitro anti-bacterial activities of Ankaferd medicinal plant extract. , 2009 .

[29]  Ankaferd Blood Stopper Tandem oral , rectal , and nasal administrations of Ankaferd Blood Stopper to control profuse bleeding leading to hemodynamic instability , 2009 .

[30]  S. Kaçar,et al.  Ankaferd Blood Stopper as an effective adjunctive hemostatic agent for the management of life-threatening arterial bleeding of the digestive tract. , 2008, Endoscopy.

[31]  S. Aksu,et al.  Endoscopic Application of Ankaferd Blood Stopper as a Novel Experimental Treatment Modality for Upper Gastrointestinal Bleeding: A Case Report , 2008, The American Journal of Gastroenterology.

[32]  Ş. Kirazlı,et al.  Haemostatic Actions of the Folkloric Medicinal Plant Extract Ankaferd Blood Stopper® , 2008, The Journal of international medical research.

[33]  A. Brewer,et al.  GUIDELINES FOR DENTAL TREATMENT OF PATIENTS WITH INHERITED BLEEDING DISORDERS , 2006 .