Trans fatty acids, blood lipids, and cardiovascular risk: where do we stand?

According to conventional wisdom, dietary substitution of vegetable fats for animal fats reduces the risk of cardiovascular heart disease (CHD). However, all forms of vegetable fat are not alike, and new research indicates that consumption of hydrogenated rather than unhydrogenated vegetable oils may negatively influence plasma lipids and risk of CHD.

[1]  J. Ordovás,et al.  Hydrogenation impairs the hypolipidemic effect of corn oil in humans. Hydrogenation, trans fatty acids, and plasma lipids. , 1993, Arteriosclerosis and thrombosis : a journal of vascular biology.

[2]  J. Manson,et al.  Intake of trans fatty acids and risk of coronary heart disease among women , 1993, The Lancet.

[3]  W. Willett,et al.  Trans-fatty acid intake in relation to serum lipid concentrations in adult men. , 1992, The American journal of clinical nutrition.

[4]  R. Mensink,et al.  Effect of dietary cis and trans fatty acids on serum lipoprotein[a] levels in humans. , 1992, Journal of lipid research.

[5]  M. Noakes,et al.  Plasma lipoprotein lipid and Lp[a] changes with substitution of elaidic acid for oleic acid in the diet. , 1992, Journal of lipid research.

[6]  M. Katan,et al.  Hydrogenation alternatives: effects of trans fatty acids and stearic acid versus linoleic acid on serum lipids and lipoproteins in humans. , 1992, Journal of lipid research.

[7]  M. Noakes,et al.  Plasma cholesterol-lowering potential of edible-oil blends suitable for commercial use. , 1992, The American journal of clinical nutrition.

[8]  T. H. Applewhite,et al.  Reassessment of trans fatty acid availability in the US diet. , 1991, The American journal of clinical nutrition.

[9]  W. Willett,et al.  Fatty acid composition of subcutaneous adipose tissue and diet in postmenopausal US women. , 1991, The American journal of clinical nutrition.

[10]  G. Getz,et al.  Use of an unsaturated fatty acid auxotroph of Saccharomyces cerevisiae to modify the lipid composition and function of mitochondrial membranes. , 1991, Journal of lipid research.

[11]  T. H. Applewhite,et al.  Isomeric fatty acids in the US diet: levels and health perspectives. , 1986, Journal of the American College of Nutrition.

[12]  F. Medzihradsky,et al.  Modulation of Opioid Receptor Binding by Cis and Trans Fatty Acids , 1990, Journal of neurochemistry.

[13]  J. Sampugna,et al.  Isomeric trans fatty acids in the U.S. diet. , 1990, Journal of the American College of Nutrition.

[14]  R. Mensink,et al.  Effect of dietary trans fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects. , 1990, The New England journal of medicine.

[15]  Daniel Steinberg,et al.  Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. The Expert Panel. , 1988, Archives of internal medicine.

[16]  R. Thompson,et al.  Lipids in margarines and margarine-like foods , 1985 .

[17]  M. Whitehurst,et al.  Selective effects of isomeric cis and trans fatty acids on fatty acyl Δ9 and Δ6 desaturation by human skin fibroblasts , 1983 .

[18]  I. Frantz,et al.  Lightly hydrogenated soy oil versus other vegetable oils as a lipid-lowering dietary constituent. , 1982, The American journal of clinical nutrition.

[19]  R. Alfin-slater,et al.  Effect of trans fatty acids on serum lecithin: cholesterol acyltransferase in rats. , 1980, The Journal of nutrition.

[20]  A. Kligman,et al.  Effect of hydrogenated fat on the plasma cholesterol and triglyceride levels of man. , 1975, The American journal of clinical nutrition.

[21]  A. Vergroesen Dietary fat and cardiovascular disease: possible modes of action of linoleic acid , 1972, Proceedings of the Nutrition Society.

[22]  A. Keys,et al.  Hydrogenated fats in the diet and lipids in the serum of man. , 1961, The Journal of nutrition.