Differentiation of breast tumors by ultrasonic tissue characterization

The ability of ultrasonic tissue characterization to differentiate and classify benign and malignant breast tissues in vivo in patients with palpable breast masses and in vitro in excised breast tissue was evaluated. One‐hundred and twenty‐four in vivo and 89 in vitro studies were performed using a technique of UTC based on parameters from the power spectrum of backscattered echoes. Sensitivities and specificities for diagnosing carcinoma were 86 and 84% for in vivo studies and 94 and 92% for in vitro studies. These UTC parameters provided threshold values for color‐coding breast lesion images. The results of this preliminary investigation suggest that UTC provides a basis for assessing more accurately lesions suspected of being malignant prior to biopsy and possibly for evaluating breast lesions noninvasively.

[1]  E. Feleppa,et al.  Theoretical framework for spectrum analysis in ultrasonic tissue characterization. , 1983, The Journal of the Acoustical Society of America.

[2]  W. Sauerbrei,et al.  Continuous-wave and pulsed Doppler studies of the breast: clinical results and effect of transducer frequency. , 1991, Ultrasound in medicine & biology.

[3]  D. Adler,et al.  Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings. , 1990, Ultrasound in medicine & biology.

[4]  P. V. van Dam,et al.  Palpable solid breast masses: retrospective single- and multimodality evaluation of 201 lesions. , 1988, Radiology.

[5]  D. Hansell,et al.  The accuracy of mammography alone and in combination with clinical examination and cytology in the detection of breast cancer. , 1988, Clinical radiology.

[6]  L. Baker,et al.  Breast cancer detection demonstration project: Five‐year summary report , 1982, CA: a cancer journal for clinicians.

[7]  S K Holland,et al.  Ultrasound tissue characterization of breast biopsy specimens. , 1991, Ultrasonic imaging.

[8]  E. Feleppa,et al.  Relationship of Ultrasonic Spectral Parameters to Features of Tissue Microstructure , 1987, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[9]  F. Lizzi.  New Developments in Ultrasonic Tissue Characterization , 1992 .

[10]  R. Golub,et al.  Age determination of experimental venous thrombi by ultrasonic tissue characterization. , 1993, Journal of vascular surgery.

[11]  I Taylor,et al.  Direct contact B-scan ultrasound in the diagnosis of solid breast masses. , 1986, Clinical radiology.

[12]  Ernest J. Feleppa,et al.  Ultrasonic Tissue Characterization for Diagnosis and Monitoring , 1987, IEEE Engineering in Medicine and Biology Magazine.

[13]  L Landini,et al.  Orientation and frequency dependence of backscatter coefficient in normal and pathological breast tissues. , 1987, Ultrasound in medicine & biology.

[14]  E A Sickles,et al.  Benign breast lesions: ultrasound detection and diagnosis. , 1984, Radiology.

[15]  G. Leopold,et al.  Real-time breast sonography: application in 300 consecutive patients. , 1986, AJR. American journal of roentgenology.

[16]  D B Kopans,et al.  "Early" breast cancer detection using techniques other than mammography. , 1984, AJR. American journal of roentgenology.

[17]  D. Rosner,et al.  What ultrasonography can tell in breast masses that mammography and physical examination cannot , 1985, Journal of surgical oncology.

[18]  R. Fisher.  THE USE OF MULTIPLE MEASUREMENTS IN TAXONOMIC PROBLEMS , 1936 .

[19]  E A Sickles,et al.  Breast cancer detection with sonography and mammography: comparison using state-of-the-art equipment. , 1983, AJR. American journal of roentgenology.

[20]  F L Bookstein,et al.  Assessment of ultrasonic computed tomography in symptomatic breast patients by discriminant analysis. , 1989, Ultrasound in medicine & biology.

[21]  R. Golub,et al.  Cellularity and fibrin mesh properties as a basis for ultrasonic tissue characterization of blood clots and thrombi. , 1992, Ultrasound in medicine & biology.