Core/shell Au/MnO nanoparticles prepared through controlled oxidation of AuMn as an electrocatalyst for sensitive H2O2 detection.

Monodisperse 5 nm AuMn nanoparticles were synthesized by hydride reduction of manganese acetylacetonate in the presence of Au nanoparticles. The alloy was formed through fast Mn diffusion into the Au structure. The AuMn nanoparticles were converted to Au-MnO composite particles through air annealing at 170 °C. These Au-MnO particles, especially the core/shell Au/MnO nanoparticles, were active for the electrochemical reduction of H2 O2 , with a detection limit reaching 8 nM. This highly sensitive electrochemical sensor based on the Au/MnO nanoparticles was used to monitor H2 O2 concentrations released from living cells, from which tumorigenic cells were discovered to release higher levels of H2 O2 than the non-tumorigenic cells.

[1]  Haifeng Lv,et al.  Monodisperse Au nanoparticles for selective electrocatalytic reduction of CO2 to CO. , 2013, Journal of the American Chemical Society.

[2]  Shouheng Sun,et al.  Monodisperse M(x)Fe(3-x)O4 (M = Fe, Cu, Co, Mn) nanoparticles and their electrocatalysis for oxygen reduction reaction. , 2013, Nano letters.

[3]  Shouheng Sun,et al.  Synthetic control of FePtM nanorods (M = Cu, Ni) to enhance the oxygen reduction reaction. , 2013, Journal of the American Chemical Society.

[4]  Shouheng Sun,et al.  Monodisperse gold-palladium alloy nanoparticles and their composition-controlled catalysis in formic acid dehydrogenation under mild conditions. , 2013, Nanoscale.

[5]  G. Cui,et al.  Manganese monoxide/titanium nitride composite as high performance anode material for rechargeable Li-ion batteries , 2012 .

[6]  Xiaolian Sun,et al.  Dumbbell-like PtPd-Fe₃O₄ nanoparticles for enhanced electrochemical detection of H₂O₂. , 2012, Nano letters.

[7]  Fei Xiao,et al.  Growth of Metal–Metal Oxide Nanostructures on Freestanding Graphene Paper for Flexible Biosensors , 2012 .

[8]  R. E. Schaak,et al.  Synthesis of Colloidal Au–Cu2S Heterodimers via Chemically Triggered Phase Segregation of AuCu Nanoparticles , 2012 .

[9]  Yuandong Zhao,et al.  Recent advances in electrochemical sensing for hydrogen peroxide: a review. , 2012, The Analyst.

[10]  Huan Wang,et al.  Electrochemical applications of platinum–palladium alloy nanoparticles/large mesoporous carbon , 2011 .

[11]  Jugal Kishore Sahoo,et al.  Hydrogen peroxide sensors for cellular imaging based on horse radish peroxidase reconstituted on polymer-functionalized TiO₂ nanorods. , 2011, Nanoscale.

[12]  Ping Wu,et al.  Electrochemical measurement of the flux of hydrogen peroxide releasing from RAW 264.7 macrophage cells based on enzyme-attapulgite clay nanohybrids. , 2011, Biosensors & bioelectronics.

[13]  Jianguo Liu,et al.  Nanoporous gold as non-enzymatic sensor for hydrogen peroxide , 2011 .

[14]  Liwen Yang,et al.  A hydrogen peroxide electrochemical sensor based on silver nanoparticles decorated silicon nanowire arrays , 2011 .

[15]  Muhammad Nawaz Tahir,et al.  Hydrogen peroxide sensing with horseradish peroxidase-modified polymer single conical nanochannels. , 2011, Analytical chemistry.

[16]  Linhai Zhuo,et al.  Direct electrochemistry of horseradish peroxidase immobilized on the layered calcium carbonate-gold nanoparticles inorganic hybrid composite. , 2010, Biosensors & bioelectronics.

[17]  Yadong Li,et al.  A seed-based diffusion route to monodisperse intermetallic CuAu nanocrystals. , 2010, Angewandte Chemie.

[18]  M. A. García,et al.  Synthetic tuning of the catalytic properties of Au-Fe3O4 nanoparticles. , 2010, Angewandte Chemie.

[19]  H. Yin,et al.  In situ phase separation of NiAu alloy nanoparticles for preparing highly active Au/NiO CO oxidation catalysts. , 2008, Chemphyschem : a European journal of chemical physics and physical chemistry.

[20]  Hongyuan Chen,et al.  Relationship between Nanostructure and Electrochemical/Biosensing Properties of MnO2 Nanomaterials for H2O2/Choline , 2008 .

[21]  Shouheng Sun,et al.  A facile synthesis of monodisperse Au nanoparticles and their catalysis of CO oxidation , 2008 .

[22]  I. Weissman,et al.  Stems Cells and the Pathways to Aging and Cancer , 2008, Cell.

[23]  Chenjie Xu,et al.  Au-Fe3O4 dumbbell nanoparticles as dual-functional probes. , 2008, Angewandte Chemie.

[24]  Jing-Juan Xu,et al.  Choline biosensors based on a bi-electrocatalytic property of MnO2 nanoparticles modified electrodes to H2O2 , 2007 .

[25]  W. Dröge,et al.  Oxidative stress and aberrant signaling in aging and cognitive decline , 2007, Aging cell.

[26]  C. Banks,et al.  Manganese Dioxide Graphite Composite Electrodes: Application to the Electroanalysis of Hydrogen Peroxide, Ascorbic Acid and Nitrite , 2007, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[27]  Yuehe Lin,et al.  Low-potential amperometric determination of hydrogen peroxide with a carbon paste electrode modified with nanostructured cryptomelane-type manganese oxides , 2005 .

[28]  M. Oyama,et al.  A hydrogen peroxide sensor based on the peroxidase activity of hemoglobin immobilized on gold nanoparticles-modified ITO electrode , 2004 .

[29]  Li Wang,et al.  A novel hydrogen peroxide sensor based on horseradish peroxidase immobilized on colloidal Au modified ITO electrode , 2004 .

[30]  D. Banerjee,et al.  Interpretation of XPS Mn(2p) spectra of Mn oxyhydroxides and constraints on the mechanism of MnO2 precipitation , 1998 .

[31]  E. A. Martins,et al.  Cellular DNA damage by hydrogen peroxide is attenuated by hypotonicity. , 1994, The Biochemical journal.

[32]  Barry Halliwell,et al.  Reactive Oxygen Species and the Central Nervous System , 1992, Journal of neurochemistry.