Understanding the traditional aspect of Chinese medicine in order to achieve meaningful quality control of Chinese materia medica.

Although sophisticated and technologically advanced, current quality control methods for Chinese medicines (syn. Chinese materia medica or CMM) lack comprehensiveness and practicability. They are more suited for analyzing single-chemical drugs or specific, known chemical components that have already been isolated. While these methods can fully satisfy the modern scientific requirements for identity, purity and quality in the assessment of chemical drugs, they are not suitable for handling the complex chemical nature of traditional CMM whose multifunctional components along with their inherent holistic activities are frequently unknown and thus are not adequately analyzed by these methods. In order to assess properly and meaningfully the identity and quality of complex CMM (also known as Chinese herbs and Chinese herbal medicines), additional measures that can retain the traditional aspect of CMM need to be included. This requires a basic understanding of traditional Chinese medicine (TCM).

[1]  Yi-Zeng Liang,et al.  Correction of retention time shifts for chromatographic fingerprints of herbal medicines. , 2004, Journal of chromatography. A.

[2]  C. Chiu,et al.  High-performance liquid chromatographic method for simultaneous quantification of eight major biologically active ingredients in 'Da-Chai-Hu-Tang' preparation. , 2006, Biomedical chromatography : BMC.

[3]  Guoan Luo,et al.  An approach to develop two-dimensional fingerprint for the quality control of Qingkailing injection by high-performance liquid chromatography with diode array detection. , 2005, Journal of chromatography. A.

[4]  Hongxi Xu,et al.  Simultaneous determination of multiple marker constituents in concentrated Gegen Tang granule by high performance liquid chromatography , 2007, Chinese medicine.

[5]  C. Xue,et al.  Chinese medicine : modern practice , 2005 .

[6]  Yi-Zeng Liang,et al.  Pretreatments of chromatographic fingerprints for quality control of herbal medicines. , 2006, Journal of chromatography. A.

[7]  Foo-Tim Chau,et al.  Chemical information of Chinese medicines: A challenge to chemist , 2006 .

[8]  M. Dermastia,et al.  A new method for the authentication of plant samples by analyzing fingerprint chromatograms. , 2007, Phytochemical analysis : PCA.

[9]  Zhen Hu,et al.  An approach to develop binary chromatographic fingerprints of the total alkaloids from Caulophyllum robustum by high performance liquid chromatography/diode array detector and gas chromatography/mass spectrometry. , 2007, Journal of pharmaceutical and biomedical analysis.

[10]  A. Y. Leung,et al.  Traditional Toxicity Documentation of Chinese Materia Medica—An Overview , 2006, Toxicologic pathology.

[11]  Xiaoru Wang,et al.  HPLC fingerprinting and LC-TOF-MS analysis of the extract of Pseudostellaria heterophylla (Miq.) Pax root. , 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[12]  Yi-zeng Liang,et al.  Chromatographic fingerprint analysis--a rational approach for quality assessment of traditional Chinese herbal medicine. , 2006, Journal of chromatography. A.

[13]  G. Lin,et al.  Pitfalls of the selection of chemical markers for the quality control of medicinal herbs , 2020 .

[14]  B. Holmbom,et al.  Chromatographic analysis of lignans. , 2006, Journal of chromatography. A.

[15]  Gui-hua Ruan,et al.  The study on the chromatographic fingerprint of Fructus xanthii by microwave assisted extraction coupled with GC-MS. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[16]  D L Massart,et al.  Chemometric treatment of vanillin fingerprint chromatograms. Effect of different signal alignments on principal component analysis plots. , 2006, Journal of chromatography. A.

[17]  L. Ding,et al.  Chemical fingerprint analysis of rhizomes of Gymnadenia conopsea by HPLC-DAD-MSn. , 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[18]  Jane Qiu,et al.  Traditional medicine: A culture in the balance , 2007, Nature.

[19]  Hongbin Xiao,et al.  Identification of phenolic constituents in Radix Salvia miltiorrhizae by liquid chromatography/electrospray ionization mass spectrometry. , 2006, Rapid communications in mass spectrometry : RCM.

[20]  Y. Heyden,et al.  Development, optimization and validation of a fingerprint of Ginkgo biloba extracts by high-performance liquid chromatography. , 2005, Journal of chromatography. A.

[21]  Yi-Zeng Liang,et al.  Variable selection for discriminating herbal medicines with chromatographic fingerprints. , 2006, Analytica chimica acta.

[22]  Yi-Zeng Liang,et al.  Quality evaluation of fingerprints of herbal medicine with chromatographic data , 2004 .

[23]  Jin-Ling Tang,et al.  Traditional Chinese medicine , 2008, The Lancet.

[24]  Yizeng Liang,et al.  LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui , 2005, Analytical and bioanalytical chemistry.

[25]  Evaluation of novel sample identification approach based on chromatographic fingerprint set correlation homogeneity analysis. , 2005, Journal of chromatography. A.

[26]  K. Putzbach,et al.  Capillary liquid chromatography-microcoil 1H nuclear magnetic resonance spectroscopy and liquid chromatography-ion trap mass spectrometry for on-line structure elucidation of isoflavones in Radix astragali. , 2005, Journal of chromatography. A.

[27]  W. Oleszek,et al.  Chromatographic determination of plant saponins--an update (2002-2005). , 2006, Journal of chromatography. A.

[28]  K. Oka,et al.  Systematic analysis of post-administrative saiboku-to urine by liquid chromatography to determine pharmacokinetics of traditional Chinese medicine. , 1997, Biomedical chromatography : BMC.

[29]  Yi-Zeng Liang,et al.  Quality control of herbal medicines. , 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[30]  T. Tanaka,et al.  Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, berberine, coptisine, palmatine, jateorrhizine and glycyrrhizin in Kampo medicines by ion-pair high-performance liquid chromatography. , 1999, Biological & pharmaceutical bulletin.

[31]  Lian‐Wen Qi,et al.  Determination of seventeen main flavonoids and saponins in the medicinal plant Huang-qi (Radix astragali) by HPLC-DAD-ELSD. , 2007, Journal of separation science.

[32]  E. de Rijke,et al.  Analytical separation and detection methods for flavonoids. , 2006, Journal of chromatography. A.

[33]  Yi-Zeng Liang,et al.  Information theory applied to chromatographic fingerprint of herbal medicine for quality control. , 2003, Journal of chromatography. A.

[34]  T. Dong,et al.  Simultaneous determination of phenols in Radix Polygalae by high performance liquid chromatography: quality assurance of herbs from different regions and seasons. , 2007, Journal of separation science.

[35]  Chunyan Yan,et al.  Fingerprint analysis of fruiting bodies of cultured Cordyceps militaris by high-performance liquid chromatography-photodiode array detection. , 2007, Journal of pharmaceutical and biomedical analysis.

[36]  L. Musselman Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics, ed. 2. Albert T. Leung, and Steven Foster , 1996, Economic Botany.

[37]  T. Dong,et al.  Verification of the formulation and efficacy of Danggui Buxue Tang (a decoction of Radix Astragali and Radix Angelicae Sinensis): an exemplifying systematic approach to revealing the complexity of Chinese herbal medicine formulae , 2007, Chinese medicine.

[38]  M. Krucker,et al.  Determination and identification of isoflavonoids in Radix astragali by matrix solid-phase dispersion extraction and high-performance liquid chromatography with photodiode array and mass spectrometric detection. , 2004, Journal of chromatography. A.

[39]  A. Y. Leung,et al.  Encyclopedia of Common Natural Ingredients: Used in Food, Drugs, and Cosmetics , 1980 .

[40]  Wen-yue Jiang,et al.  Therapeutic wisdom in traditional Chinese medicine: a perspective from modern science. , 2005, Trends in pharmacological sciences.

[41]  P. Drasar,et al.  Recent advances in analysis of Chinese medical plants and traditional medicines. , 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[42]  Y Z Liang,et al.  Identification and quality assessment of Houttuynia cordata injection using GC-MS fingerprint: a standardization approach. , 2006, Journal of ethnopharmacology.

[43]  Feng Gan,et al.  New approach on similarity analysis of chromatographic fingerprint of herbal medicine. , 2006, Journal of chromatography. A.