GLUT3 and PKM2 regulate OCT4 expression and support the hypoxic culture of human embryonic stem cells
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[1] H. Jang,et al. Core Pluripotency Factors Directly Regulate Metabolism in Embryonic Stem Cell to Maintain Pluripotency , 2015, Stem cells.
[2] T. Sanchez-Elsner,et al. HIF-2α Regulates NANOG Expression in Human Embryonic Stem Cells following Hypoxia and Reoxygenation through the Interaction with an Oct-Sox Cis Regulatory Element , 2014, PloS one.
[3] K. Aldape,et al. PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis , 2014, Cell.
[4] Shuo Lin,et al. GLUT3 gene expression is critical for embryonic growth, brain development and survival. , 2014, Molecular genetics and metabolism.
[5] Bo Zhang,et al. The effect of HIF-1α on glucose metabolism, growth and apoptosis of pancreatic cancerous cells. , 2014, Asia Pacific journal of clinical nutrition.
[6] E. Wanker,et al. HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1–3 and PKM2 , 2014, Stem cells.
[7] P. Calder,et al. Effect of Oxygen Tension on the Amino Acid Utilisation of Human Embryonic Stem Cells , 2014, Cellular Physiology and Biochemistry.
[8] Angela M. Liu,et al. miR-122 Targets Pyruvate Kinase M2 and Affects Metabolism of Hepatocellular Carcinoma , 2014, PloS one.
[9] C. Pecqueur,et al. Control of glioma cell death and differentiation by PKM2–Oct4 interaction , 2014, Cell Death and Disease.
[10] H. Kung,et al. JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α–mediated glucose metabolism , 2013, Proceedings of the National Academy of Sciences.
[11] D. K. Arrell,et al. Metabolome and metaboproteome remodeling in nuclear reprogramming , 2013, Cell cycle.
[12] T. Sanchez-Elsner,et al. Environmental Oxygen Tension Regulates the Energy Metabolism and Self-Renewal of Human Embryonic Stem Cells , 2013, PloS one.
[13] K. Aldape,et al. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect , 2012, Nature Cell Biology.
[14] Patrick S. Stumpf,et al. Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity , 2012, Nature Cell Biology.
[15] Xueliang Gao,et al. Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase. , 2012, Molecular cell.
[16] Michael S. Goldberg,et al. Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression , 2012, The Journal of experimental medicine.
[17] Timothy J. Nelson,et al. Energy metabolism in nuclear reprogramming. , 2011, Biomarkers in medicine.
[18] Juan Carlos Izpisua Belmonte,et al. The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming , 2011, Cell Research.
[19] K. Aldape,et al. Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation , 2011, Nature.
[20] S. Mazurek. Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells. , 2011, The international journal of biochemistry & cell biology.
[21] G. Schatten,et al. Energy Metabolism in Human Pluripotent Stem Cells and Their Differentiated Counterparts , 2011, PloS one.
[22] Matthew K. Knabel,et al. Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1 , 2011, Cell.
[23] L. Squire,et al. Memory, Visual Discrimination Performance, and the Human Hippocampus , 2011, The Journal of Neuroscience.
[24] Jason W. Locasale,et al. Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells , 2010, Science.
[25] Shau-Ping Lin,et al. Hypoxic culture maintains self-renewal and enhances embryoid body formation of human embryonic stem cells. , 2010, Tissue engineering. Part A.
[26] P. Andrews,et al. Generation of Sheffield (Shef) human embryonic stem cell lines using a microdrop culture system , 2010, In Vitro Cellular & Developmental Biology - Animal.
[27] Richard O C Oreffo,et al. Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions , 2010, Reproduction.
[28] Jing Chen,et al. Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth , 2009, Science Signaling.
[29] A. Ben-Yehudah,et al. Enhancement of human embryonic stem cell pluripotency through inhibition of the mitochondrial respiratory chain. , 2009, Stem cell research.
[30] V. Zachar,et al. Continuous hypoxic culturing maintains activation of Notch and allows long‐term propagation of human embryonic stem cells without spontaneous differentiation , 2009, Cell proliferation.
[31] L. Hearne,et al. Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells. , 2008, Stem cells and development.
[32] H. Christofk,et al. Pyruvate kinase M2 is a phosphotyrosine-binding protein , 2008, Nature.
[33] Ru Wei,et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth , 2008, Nature.
[34] N. Illsley,et al. Hypoxic upregulation of glucose transporters in BeWo choriocarcinoma cells is mediated by hypoxia-inducible factor-1. , 2007, American journal of physiology. Cell physiology.
[35] H. Han,et al. Effect of Hypoxia on 2-Deoxyglucose Uptake and Cell Cycle Regulatory Protein Expression of Mouse Embryonic Stem Cells: Involvement of Ca2+ /PKC, MAPKs and HIF-1α , 2007, Cellular Physiology and Biochemistry.
[36] A. Ullrich,et al. Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death. , 2007, Cancer research.
[37] Andre Terzic,et al. Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells , 2007, Nature Clinical Practice Cardiovascular Medicine.
[38] D. Beach,et al. A high glycolytic flux supports the proliferative potential of murine embryonic stem cells. , 2006, Antioxidants & redox signaling.
[39] X. Chen,et al. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells , 2006, Nature Genetics.
[40] Megan F. Cole,et al. Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells , 2005, Cell.
[41] R. Roberts,et al. Low O2 tensions and the prevention of differentiation of hES cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[42] A. Harvey,et al. Oxygen‐regulated expression of GLUT‐1, GLUT‐3, and VEGF in the mouse blastocyst , 2005, Molecular reproduction and development.
[43] Chad A. Cowan,et al. Derivation of embryonic stem-cell lines from human blastocysts. , 2004, The New England journal of medicine.
[44] Huasheng Lu,et al. Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis* , 2002, The Journal of Biological Chemistry.
[45] H. Leese,et al. Non-invasive amino acid turnover predicts human embryo developmental capacity. , 2002, Human reproduction.
[46] J. Thomson,et al. Embryonic stem cell lines derived from human blastocysts. , 1998, Science.
[47] D. James,et al. Glucose transporter GLUT3: ontogeny, targeting, and role in the mouse blastocyst. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[48] F. Ismail-Beigi,et al. The effect of hypoxia on human trophoblast in culture: morphology, glucose transport and metabolism. , 1997, Placenta.
[49] G. Semenza,et al. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. , 1994, The Journal of biological chemistry.
[50] S. Morgello,et al. Tissue distribution of the human GLUT3 glucose transporter. , 1993, Endocrinology.
[51] T. Jess,et al. Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors. , 1993, The Biochemical journal.
[52] C. Burant,et al. Mammalian facilitative glucose transporters: evidence for similar substrate recognition sites in functionally monomeric proteins. , 1992, Biochemistry.
[53] B. Kahn,et al. Distribution of GLUT3 glucose transporter protein in human tissues. , 1992, Biochemical and biophysical research communications.
[54] J. Flier,et al. Regulation of Glucose-Transporter Gene Expression In Vitro and In Vivo , 1990, Diabetes Care.
[55] G. Lienhard,et al. The blood—nerve barrier is rich in glucose transporter , 1988, Journal of neurocytology.
[56] A. McCall,et al. Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man. , 1987, The Journal of clinical investigation.
[57] T. Tanaka,et al. The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing. , 1986, The Journal of biological chemistry.
[58] G. Martin,et al. Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. , 1981, Proceedings of the National Academy of Sciences of the United States of America.
[59] M. Kaufman,et al. Establishment in culture of pluripotential cells from mouse embryos , 1981, Nature.
[60] E. Boyland. Metabolism of Tumours , 1940, Nature.
[61] J. Shirlaw. THE METABOLISM OF TUMOURS , 1931 .
[62] Jungho Kim,et al. Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. , 2008, The international journal of biochemistry & cell biology.
[63] P. Huppert,et al. Expression of hypoxia-inducible genes in tumor cells , 1998, Journal of Cancer Research and Clinical Oncology.
[64] J A Thomson,et al. Primate embryonic stem cells. , 1998, Current topics in developmental biology.
[65] C. Burant,et al. Mammalian glucose transporters: structure and molecular regulation. , 1991, Recent progress in hormone research.