Morphological and morphometric changes in the Purkinje cells of patients with essential tremor

Essential tremor (ET) is a progressive neurological syndrome characterised by involuntary tremors of the hands or arms, head, jaw and voice. The pathophysiology of ET is not clearly understood yet. However, previous studies have reported several changes in the brain of patients with ET. One of the brain areas extensively investigated is the cerebellum. In the present study, a morphometric analysis of Purkinje cells in patients with ET and ET-plus was performed, and subsequently compared with normal controls using the Golgi silver staining method and 3D neuronal reconstruction. Substantial morphological changes were uncovered in the Purkinje cells of patients with ET compared with normal controls, including a decreased dendritic length and field density, an overall loss of terminal branches and a decreased density of dendritic spines.

[1]  P. Pan,et al.  No reliable gray matter changes in essential tremor , 2019, Neurological Sciences.

[2]  H. Shang,et al.  A Voxel-Wise Meta-Analysis of Gray Matter Abnormalities in Essential Tremor , 2018, Front. Neurol..

[3]  U. Dydak,et al.  Cerebral gray matter volume losses in essential tremor: A case-control study using high resolution tissue probability maps. , 2018, Parkinsonism & related disorders.

[4]  M. Hallett,et al.  A Voxel-Based Magnetic Resonance Imaging Morphometric Study of Cerebral and Cerebellar Gray Matter in Patients Under 65 Years with Essential Tremor , 2018, Medical science monitor : international medical journal of experimental and clinical research.

[5]  Derek B Archer,et al.  A widespread visually-sensitive functional network relates to symptoms in essential tremor , 2018, Brain : a journal of neurology.

[6]  Kevin W. Eliceiri,et al.  ImageJ2: ImageJ for the next generation of scientific image data , 2017, BMC Bioinformatics.

[7]  Jong-Min Lee,et al.  Atrophy of the Cerebellar Vermis in Essential Tremor: Segmental Volumetric MRI Analysis , 2016, The Cerebellum.

[8]  T. Luo,et al.  Essential tremor is associated with disruption of functional connectivity in the ventral intermediate Nucleus—Motor Cortex—Cerebellum circuit , 2016, Human brain mapping.

[9]  N. Maurits,et al.  Cerebellar Atrophy in Cortical Myoclonic Tremor and Not in Hereditary Essential Tremor—a Voxel-Based Morphometry Study , 2015, The Cerebellum.

[10]  S. Lehéricy,et al.  Intrinsic signature of essential tremor in the cerebello-frontal network. , 2015, Brain : a journal of neurology.

[11]  S. Diciotti,et al.  Morphometric and functional MRI changes in essential tremor with and without resting tremor , 2015, Journal of Neurology.

[12]  J. Vonsattel,et al.  Reduced Purkinje cell dendritic arborization and loss of dendritic spines in essential tremor. , 2014, Brain : a journal of neurology.

[13]  A. Koeppen,et al.  Abnormal climbing fibre-Purkinje cell synaptic connections in the essential tremor cerebellum. , 2014, Brain : a journal of neurology.

[14]  Aart J. Nederveen,et al.  Neuroimaging essentials in essential tremor: A systematic review , 2014, NeuroImage: Clinical.

[15]  H. Shill,et al.  Essential tremor is not associated with cerebellar Purkinje cell loss , 2014, Movement disorders : official journal of the Movement Disorder Society.

[16]  A. Rao,et al.  Four Essential Tremor Cases with Moderately Impaired Gait: How Impaired can Gait be in this Disease? , 2013, Tremor and other hyperkinetic movements.

[17]  J. Vonsattel,et al.  Purkinje cell axonal anatomy: quantifying morphometric changes in essential tremor versus control brains. , 2013, Brain : a journal of neurology.

[18]  Paul A. Wetzel,et al.  Slowed Saccades and Increased Square Wave Jerks in Essential Tremor , 2013, Tremor and other hyperkinetic movements.

[19]  Yih-Ru Wu,et al.  SLC1A2 Variant Is Associated with Essential Tremor in Taiwanese Population , 2013, PloS one.

[20]  Qing X. Yang,et al.  Abnormal Regional Homogeneity in Patients with Essential Tremor Revealed by Resting-State Functional MRI , 2013, PloS one.

[21]  J. Chiou,et al.  VBM Reveals Brain Volume Differences between Parkinson’s Disease and Essential Tremor Patients , 2013, Front. Hum. Neurosci..

[22]  Elan D. Louis,et al.  Postural and Intention Tremors: A Detailed Clinical Study of Essential Tremor vs. Parkinson’s Disease , 2013, Front. Neurol..

[23]  E. Louis The primary type of tremor in essential tremor is kinetic rather than postural: cross‐sectional observation of tremor phenomenology in 369 cases , 2013, European journal of neurology.

[24]  Günther Deuschl,et al.  Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor , 2012, Neurology.

[25]  H. Shill,et al.  Essential tremor is not a neurodegenerative disease. , 2012, Neurodegenerative disease management.

[26]  R. Bharath,et al.  Diffusion tensor imaging: tract based spatial statistics study in essential tremor. , 2012, Parkinsonism & related disorders.

[27]  Liu Jia,et al.  A Diffusion Tensor Imaging Study in Essential Tremor , 2011, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[28]  R. Hilker,et al.  Diffusion tensor imaging of white matter involvement in essential tremor , 2011, Human brain mapping.

[29]  J. Vonsattel,et al.  Increased number of heterotopic Purkinje cells in essential tremor , 2010, Journal of Neurology, Neurosurgery & Psychiatry.

[30]  B. Barbiroli,et al.  Diffusion tensor MRI changes in cerebellar structures of patients with familial essential tremor , 2010, Neurology.

[31]  L. Honig,et al.  "Hairy Baskets" Associated With Degenerative Purkinje Cell Changes in Essential Tremor , 2010, Journal of neuropathology and experimental neurology.

[32]  J. Benito-León,et al.  Brain structural changes in essential tremor: Voxel-based morphometry at 3-Tesla , 2009, Journal of the Neurological Sciences.

[33]  J. Raduà,et al.  Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder. , 2009, The British journal of psychiatry : the journal of mental science.

[34]  J. Vonsattel,et al.  Structural study of Purkinje cell axonal torpedoes in essential tremor , 2009, Neuroscience Letters.

[35]  L. Lemieux,et al.  Essential Head Tremor Is Associated with Cerebellar Vermis Atrophy: A Volumetric and Voxel-Based Morphometry MR Imaging Study , 2008, American Journal of Neuroradiology.

[36]  J. Vonsattel,et al.  The emerging neuropathology of essential tremor , 2008, Movement disorders : official journal of the Movement Disorder Society.

[37]  H. Kim,et al.  Diffusion Tensor Imaging in Patients With Essential Tremor , 2008, American Journal of Neuroradiology.

[38]  K. Lyons,et al.  Neuropathological changes in essential tremor: 33 cases compared with 21 controls. , 2007, Brain : a journal of neurology.

[39]  B. Barbiroli,et al.  Diffusion‐weighted imaging study of patients with essential tremor , 2007, Movement disorders : official journal of the Movement Disorder Society.

[40]  C. Daniels,et al.  Voxel-based morphometry shows no decreases in cerebellar gray matter volume in essential tremor , 2006, Neurology.

[41]  R. Uitti,et al.  Essential tremor: predictors of disease progression in a clinical cohort , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[42]  E D Louis,et al.  Neuropathologic findings in essential tremor , 2006, Neurology.

[43]  J. Benito-León,et al.  Population-based case-control study of cognitive function in essential tremor , 2006, Neurology.

[44]  J. Jankovic,et al.  Hearing impairment in essential tremor , 2003, Neurology.

[45]  A. Lang,et al.  The cerebellothalamocortical pathway in essential tremor , 2003, Neurology.

[46]  Oren Cohen,et al.  Rest tremor in patients with essential tremor: prevalence, clinical correlates, and electrophysiologic characteristics. , 2003, Archives of neurology.

[47]  E. Louis,et al.  Olfactory dysfunction in essential tremor: A deficit unrelated to disease duration or severity , 2002 .

[48]  B. Jacobs,et al.  Life‐span dendritic and spine changes in areas 10 and 18 of human cortex: A quantitative golgi study , 1997, The Journal of comparative neurology.

[49]  P. Thompson,et al.  A positron emission tomography study of cerebral activation associated with essential and writing tremor. , 1995, Archives of neurology.

[50]  Marjorie F. Martin A Physiological Approach To Clinical Neurology , 1971 .

[51]  Stavros J. Baloyannis,et al.  Purkinje cells pathology in schizophrenia. A morphometric approach. , 2017, Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie.

[52]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[53]  A. Rajput,et al.  Defective dentate nucleus GABA receptors in essential tremor. , 2012, Brain : a journal of neurology.

[54]  Rajesh Pahwa,et al.  Reduced Purkinje cell number in essential tremor: a postmortem study. , 2008, Archives of neurology.

[55]  J. Rilling The Evolution of the Cerebellum in Anthropoid Primates , 2007 .

[56]  G. Deuschl,et al.  The pathophysiology of essential tremor. , 2000, Neurology.

[57]  P. Yates,et al.  The fine structure of the axonal torpedo in Purkinje cells of the human cerebellum. , 1980, Neurological research.

[58]  D. Sholl The organization of the visual cortex in the cat. , 1955, Journal of anatomy.

[59]  S. Parlee,et al.  This Work Is Licensed under a Creative Commons Attribution-noncommercial 4.0 International License , 2022 .