PARP1 blockade is synthetically lethal in XRCC1 deficient sporadic epithelial ovarian cancers.
暂无分享,去创建一个
E. Rakha | R. Ali | I. Miligy | K. A. Mesquita | S. Madhusudan | Stephen Y. T. Chan | Adel Alblihy | P. Moseley | M. Alabdullah | S. Chan | K. Mesquita
[1] Stephen S. Taylor,et al. DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors , 2019, Cancer cell.
[2] Q. Xiang,et al. XRCC1 polymorphism and overall survival in ovarian cancer patients treated with platinum-based chemotherapy , 2018, Medicine.
[3] A. Green,et al. Targeting PARP1 in XRCC1-Deficient Sporadic Invasive Breast Cancer or Preinvasive Ductal Carcinoma In Situ Induces Synthetic Lethality and Chemoprevention. , 2018, Cancer research.
[4] Kedar S Vaidya,et al. Abstract 1943: PARG inhibitors exhibit synthetic lethality with XRCC1 deficiency and a cellular mechanism of action that is distinct from PARP inhibition , 2018, Experimental and Molecular Therapeutics.
[5] M. Lopes,et al. Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality. , 2018, Cancer cell.
[6] Dumessa Edessa,et al. PARP inhibitors as potential therapeutic agents for various cancers: focus on niraparib and its first global approval for maintenance therapy of gynecologic cancers , 2017, Gynecologic Oncology Research and Practice.
[7] Junnian Zheng,et al. XRCC1 serves as a potential prognostic indicator for clear cell renal cell carcinoma and inhibits its invasion and metastasis through suppressing MMP-2 and MMP-9 , 2017, Oncotarget.
[8] H. Bryant,et al. Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase , 2017, DNA repair.
[9] Alan Ashworth,et al. PARP inhibitors: Synthetic lethality in the clinic , 2017, Science.
[10] Ying Chen,et al. Meta-analysis of XRCC1 polymorphism and risk of female reproductive system cancer , 2017, Oncotarget.
[11] Keith W. Caldecott,et al. XRCC1 Mutation is Associated with PARP1 Hyperactivation and Cerebellar Ataxia , 2016, Nature.
[12] Anne Floquet,et al. Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial. , 2017, The Lancet. Oncology.
[13] Ignace Vergote,et al. Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer. , 2016, The New England journal of medicine.
[14] E. Swisher,et al. Biomarkers of Response and Resistance to DNA Repair Targeted Therapies , 2016, Clinical Cancer Research.
[15] R. London. The structural basis of XRCC1-mediated DNA repair. , 2015, DNA repair.
[16] C. Walsh. Two decades beyond BRCA1/2: Homologous recombination, hereditary cancer risk and a target for ovarian cancer therapy. , 2015, Gynecologic oncology.
[17] Alan Ashworth,et al. Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors. , 2015, Annual review of medicine.
[18] Chunhong Hu,et al. XRCC1 genetic polymorphism acts a potential biomarker for lung cancer , 2015, Tumor Biology.
[19] James D. Brenton,et al. Ovarian Cancer Cell Line Panel (OCCP): Clinical Importance of In Vitro Morphological Subtypes , 2014, PloS one.
[20] M. Martinka,et al. Loss of XRCC1 confers a metastatic phenotype to melanoma cells and is associated with poor survival in patients with melanoma , 2014, Pigment cell & melanoma research.
[21] Samuel H. Wilson,et al. Base Excision Repair Defects Invoke Hypersensitivity to PARP Inhibition , 2014, Molecular Cancer Research.
[22] A. Green,et al. Poly(adenosine diphosphate-ribose) polymerase expression in BRCA-proficient ovarian high-grade serous carcinoma; association with patient survival. , 2013, Human pathology.
[23] C. Seedhouse,et al. Clinicopathological and functional significance of XRCC1 expression in ovarian cancer , 2013, International journal of cancer.
[24] D. Matei,et al. Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer. , 2012, The New England journal of medicine.
[25] H. Bryant,et al. Inhibition of poly(ADP-ribose) glycohydrolase (PARG) specifically kills BRCA2-deficient tumor cells , 2012, Cell cycle.
[26] Jay W. Wright,et al. BRCAness Profile of Sporadic Ovarian Cancer Predicts Disease Recurrence , 2012, PloS one.
[27] Tianying Zheng,et al. XRCC1-77T>C polymorphism and cancer risk: a meta- analysis. , 2012, Asian Pacific journal of cancer prevention : APJCP.
[28] Zhao-Qi Wang,et al. Poly (ADP-ribose) glycohydrolase (PARG) and its therapeutic potential. , 2009, Frontiers in bioscience.
[29] A. Ashworth,et al. A high-throughput RNA interference screen for DNA repair determinants of PARP inhibitor sensitivity. , 2008, DNA repair.
[30] S. Desnoyers,et al. Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: a nuclear target protein of PARP-1 , 2007, BMC Molecular Biology.
[31] T. Dawson,et al. The Road to Survival Goes through PARG , 2005, Cell cycle.
[32] K. Caldecott. XRCC1 and DNA strand break repair. , 2003, DNA repair.
[33] M. Masson,et al. XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage , 1998, Molecular and Cellular Biology.