Intelligent Integrative Knowledge Bases: Bridging Genomics, Integrative Biology and Translational Medicine

Successful application of translational medicine will require understanding the complex nature of disease, fueled by effective analysis of multidimensional ’omics’ measurements and systems-level studies. In this paper, we present a perspective — the intelligent integrative knowledge base (I2KB)— for data management, statistical analysis and knowledge discovery related to human disease. By building a bridge between patient associations, clinicians, experimentalists and modelers, I2KB will facilitate the emergence and propagation of systems medicine studies, which are a prerequisite for large-scaled clinical trial studies, efficient diagnosis, disease screening, drug target evaluation and development of new therapeutic strategies.

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