论文信息 - High frequency stimulation of the STN influences the activity of dopamine neurons in the rat

High frequency stimulation of the STN influences the activity of dopamine neurons in the rat

&NA; The effect of high frequency stimulation (HFS) of the subthalamic nucleus (STN) on the spontaneous activity of substantia nigra pars compacta (SNc) dopaminergic neurons was investigated in normal rats and in rats with globus pallidus (GP) lesions. In normal rats, the spontaneous activity of SNc neurons did not significantly differ from that of rats with GP lesions (4.2 ± 2.2 versus 4.4 ± 2.6 spikes/s). STN‐HFS induced an increase of firing rate in the majority of tested cells in normal (76%) and GP‐lesioned rats (73%) with an after‐effect of 34.4 ± 3.4 and 33.2 ± 3.1 s, respectively. These results demonstrate that STN‐HFS influences the activity of the SNc dopaminergic neurons by increasing their firing rate and that this increase of activity is independent of the globus pallidus.

[1] O. Hassani,et al. Increased subthalamic neuronal activity after nigral dopaminergic lesion independent of disinhibition via the globus pallidus , 1996, Neuroscience.

[2] P. Robledo,et al. Excitatory influence of rat subthalamic nucleus to substantia nigra pars reticulata and the pallidal complex: electrophysiological data , 1990, Brain Research.

[3] L. Swanson. The Rat Brain in Stereotaxic Coordinates, George Paxinos, Charles Watson (Eds.). Academic Press, San Diego, CA (1982), vii + 153, $35.00, ISBN: 0 125 47620 5 , 1984 .

[4] A. Grace,et al. Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization , 1983, Neuroscience.

[5] A. Grace,et al. Role of the subthalamic nucleus in the regulation of nigral dopamine neuron activity , 1992, Synapse.

[6] B. Bioulac,et al. Effect of subthalamic high frequency stimulation on substantia nigra pars reticulata and globus pallidus neurons in normal rats , 1994, Journal of Physiology-Paris.

[7] A. Grace,et al. Paradoxical GABA excitation of nigral dopaminergic cells: indirect mediation through reticulata inhibitory neurons. , 1979, European journal of pharmacology.

[8] H. Groenewegen,et al. Connections of the subthalamic nucleus with ventral striatopallidal parts of the basal ganglia in the rat , 1990, The Journal of comparative neurology.