Cyrmenins, Novel Antifungal Peptides Containing a Nitrogen‐Linked β‐Methoxyacrylate Pharmacophore: Isolation and Structural Elucidation

The novel antifungal metabolites cyrmenin A, B1, and B2 (1−3) were isolated from Archangium gephyra and Cystobacter armeniaca strains (myxobacteria). The cyrmenins are modified N-acyldipeptide esters containing a didehydroalanine, a 3-O-methyl-didehydroserine and a (2E,4Z)-undecadienoic or -dodecadienoic acid residue. These compounds represent the first bacterial counterparts of strobilurins that are characterized by an α-substituted β-methoxyacrylate pharmacophore. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)