Effects of dietary components on GI absorption of acetaminophen tablets in man.

Various high carbohydrate, high protein, and high lipid test meals were administered concurrently with acetaminophen tablets to human subjects to study the effects of foods on GI absorption of this drug. Balanced test meals and a fasting condition were also employed. An indication of the rate and extent of drug absorption was obtained by measuring urinary excretion at 1.5-hr. intervals over a 9-hr. period. The initial rate of excretion of acetaminophen and its metabolites was significantly reduced with a majority of the carbohydrate test meals. High protein, high lipid, or balanced meals appeared to have no statistically significant effect, while the fasting condition showed only a trend toward initially higher excretion values. The cumulative amounts of total acetaminophen and metabolites excreted in the urine at the end of 9 hr. showed little difference among test meals. The apparent inhibition of acetaminophen absorption by carbohydrate test meals could be partially attributed to an interaction with pectin in some cases.

[1]  Joseph L. Kanig,et al.  The theory and practice of industrial pharmacy , 1970 .

[2]  E. Townley,et al.  Parameters affecting absorption of griseofulvin in a human subject using urinary metabolite excretion data. , 1970, Journal of pharmaceutical sciences.

[3]  J. Swarbrick.  Current concepts in the pharmaceutical sciences : biopharmaceutics , 1970 .

[4]  Z. Mansour,et al.  Complexing behavior of starches with certain pharmaceuticals. , 1968, Journal of pharmaceutical sciences.

[5]  H. Davenport.  Physiology of the Digestive Tract , 1967 .

[6]  J. Wood.  EFFECT OF FOOD ON ASPIRIN ABSORPTION , 1967 .

[7]  G Levy,et al.  Absorption, metabolism, and excretion of riboflavin-5'-phosphate in man. , 1967, Journal of pharmaceutical sciences.

[8]  Joseph L. Kanig,et al.  Increasing Dissolution Rates and Gastrointestinal Absorption of Drugs via solid Solutions and Eutectic mixtures II: Experimental Evaluation of a Eutectic Mixture: Urea-acetaminophen System , 1966 .

[9]  W. Jusko,et al.  Factors affecting the absorption of riboflavin in man. , 1966, Journal of pharmaceutical sciences.

[10]  A. Conney,et al.  A simple method for the quantitative determination of N-acetyl-p-aminophenol (APAP) in urine. , 1965, Clinical chemistry.

[11]  R. G. Crounse,et al.  Human pharmacology of griseofulvin: the effect of fat intake on gastrointestinal absorption. , 1961, The Journal of investigative dermatology.

[12]  M. Finland,et al.  EFFECT OF FOOD ON THE ABSORPTION OF ERYTHROMYCIN PROPIONATE, ERYTHROMYCIN STEARATE AND TRIACETYLOLEANDOMYCIN , 1959, The American journal of the medical sciences.

[13]  M. Finland,et al.  THE EFFECT OF FOOD AND ALKALI ON THE ABSORPTION AND EXCRETION OF SULFONAMIDE DRUGS AFTER ORAL AND DUODENAL ADMINISTRATION , 1942 .