Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy

[1]  A. Goldberg,et al.  IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1. , 2004, American journal of physiology. Endocrinology and metabolism.

[2]  G. Yancopoulos,et al.  The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. , 2004, Molecular cell.

[3]  W. Aird,et al.  The Akt-regulated Forkhead Transcription Factor FOXO3a Controls Endothelial Cell Viability through Modulation of the Caspase-8 Inhibitor FLIP* , 2004, Journal of Biological Chemistry.

[4]  A. Goldberg,et al.  Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[5]  T. Furuyama,et al.  Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation. , 2003, The Biochemical journal.

[6]  D. Accili,et al.  Regulation of insulin-like growth factor–dependent myoblast differentiation by Foxo forkhead transcription factors , 2003, The Journal of cell biology.

[7]  P. Coffer,et al.  FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons , 2003, The Journal of cell biology.

[8]  R. Tjian,et al.  Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. , 2003, Genes & development.

[9]  J. Kramer,et al.  Expression of Drosophila FOXO regulates growth and can phenocopy starvation , 2003, BMC Developmental Biology.

[10]  Jennifer Skeen,et al.  Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. , 2003, Genes & development.

[11]  A. Goldberg,et al.  TNF‐α increases ubiquitin‐conjugating activity in skeletal muscle by up‐regulating UbcH2/E220k , 2003 .

[12]  Bruce M. Spiegelman,et al.  Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction , 2003, Nature.

[13]  Paul Tempst,et al.  GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. , 2003, Molecular cell.

[14]  M. Imae,et al.  Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16. , 2003, Journal of molecular endocrinology.

[15]  Eric C. Griffith,et al.  The Many Forks in FOXO's Road , 2003, Science's STKE.

[16]  G. Grosveld,et al.  FKHR (FOXO1a) is required for myotube fusion of primary mouse myoblasts , 2003, The EMBO journal.

[17]  Michael T. McManus,et al.  A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference , 2003, Nature Genetics.

[18]  D. Accili,et al.  The forkhead transcription factor Foxo1 regulates adipocyte differentiation. , 2003, Developmental cell.

[19]  M. Birnbaum,et al.  Regulation of Angiogenesis by Glycogen Synthase Kinase-3β* , 2002, The Journal of Biological Chemistry.

[20]  A. Goldberg,et al.  Patterns of gene expression in atrophying skeletal muscles: response to food deprivation , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[21]  D. Accili,et al.  Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1 , 2002, Nature Genetics.

[22]  W. Sellers,et al.  A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. , 2002, Cancer cell.

[23]  E. Calabria,et al.  A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[24]  A. Barta.  Faculty Opinions recommendation of A system for stable expression of short interfering RNAs in mammalian cells. , 2002 .

[25]  R. Bernards,et al.  A System for Stable Expression of Short Interfering RNAs in Mammalian Cells , 2002, Science.

[26]  A. Goldberg,et al.  Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[27]  C. Rommel,et al.  Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways , 2001, Nature Cell Biology.

[28]  G. Yancopoulos,et al.  Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo , 2001, Nature Cell Biology.

[29]  D. Accili,et al.  The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. , 2001, The Journal of clinical investigation.

[30]  D J Glass,et al.  Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy , 2001, Science.

[31]  A. Goldberg,et al.  What do we really know about the ubiquitin-proteasome pathway in muscle atrophy? , 2001, Current opinion in clinical nutrition and metabolic care.

[32]  C. Y. Wang,et al.  NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. , 2000, Science.

[33]  G. Ruvkun,et al.  DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[34]  T. Nakazawa,et al.  Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. , 2000, The Biochemical journal.

[35]  A. Israël.  The IKK complex: an integrator of all signals that activate NF-κB? , 2000 .

[36]  T. Lømo,et al.  Ras is involved in nerve-activity-dependent regulation of muscle genes , 2000, Nature Cell Biology.

[37]  E. Wilder,et al.  Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB , 1999, Nature Cell Biology.

[38]  A. Musarò,et al.  IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1 , 1999, Nature.

[39]  P. Hasselgren.  Glucocorticoids and muscle catabolism. , 1999, Current opinion in clinical nutrition and metabolic care.

[40]  Claudine Jurkovitz,et al.  Evaluation of signals activating ubiquitin-proteasome proteolysis in a model of muscle wasting. , 1999, American journal of physiology. Cell physiology.

[41]  M. Greenberg,et al.  Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor , 1999, Cell.

[42]  A. Goldberg,et al.  Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states. , 1999, The Journal of nutrition.

[43]  Michael R. Green,et al.  Gene Expression , 1993, Progress in Gene Expression.