Noscapine recirculates enterohepatically and induces self-clearance.
暂无分享,去创建一个
[1] R. Aneja,et al. Modulation of Cytochrome P450 Metabolism and Transport across Intestinal Epithelial Barrier by Ginger Biophenolics , 2014, PloS one.
[2] N. Zhang,et al. Characterization of Inhibition Kinetics of (S)-Warfarin Hydroxylation by Noscapine: Implications in Warfarin Therapy , 2013, Drug Metabolism and Disposition.
[3] Xue-jia Zhai,et al. Capsaicin pretreatment increased the bioavailability of cyclosporin in rats: involvement of P-glycoprotein and CYP 3A inhibition. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
[4] J. Kanwar,et al. Influence of curcumin on pioglitazone metabolism and pk/pd: Diabetes Mellitus , 2013 .
[5] Jian-Guo Chen,et al. Food-drug interactions: effect of capsaicin on the pharmacokinetics of simvastatin and its active metabolite in rats. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
[6] F. Gonzalez,et al. Metabolic map and bioactivation of the anti‐tumour drug noscapine , 2012, British journal of pharmacology.
[7] M. Wink,et al. Piperine, a piperidine alkaloid from Piper nigrum re-sensitizes P-gp, MRP1 and BCRP dependent multidrug resistant cancer cells. , 2011, Phytomedicine : international journal of phytotherapy and phytopharmacology.
[8] E. Oroudjev,et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules , 2010, Molecular Cancer Therapeutics.
[9] William M. Lee,et al. Hepatic Drug-Metabolizing Enzyme Induction and Implications for Preclinical and Clinical Risk Assessment , 2010, Toxicologic pathology.
[10] P. Anzenbacher,et al. Phase II drug metabolizing enzymes. , 2010, Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.
[11] Dion R. Brocks,et al. Multiple Peaking Phenomena in Pharmacokinetic Disposition , 2010, Clinical pharmacokinetics.
[12] A. Scheepens,et al. Improving the oral bioavailability of beneficial polyphenols through designed synergies , 2010, Genes & Nutrition.
[13] Leslie Z. Benet,et al. The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs , 2009, Pharmaceutical Research.
[14] L. Lim,et al. Effects of Spice Constituents on P-Glycoprotein-Mediated Transport and CYP3A4-Mediated Metabolism in Vitro , 2008, Drug Metabolism and Disposition.
[15] Robert A Newman,et al. Bioavailability of curcumin: problems and promises. , 2007, Molecular pharmaceutics.
[16] R. Chandra,et al. Preclinical pharmacokinetics and bioavailability of noscapine, a tubulin-binding anticancer agent , 2007, Cancer Chemotherapy and Pharmacology.
[17] K. Naidu,et al. Spice phenolics inhibit human PMNL 5-lipoxygenase. , 2004, Prostaglandins, leukotrienes, and essential fatty acids.
[18] A. Braune,et al. Transformation of flavonoids by intestinal microorganisms. , 2003, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.
[19] J. Ritter. Roles of glucuronidation and UDP-glucuronosyltransferases in xenobiotic bioactivation reactions. , 2000, Chemico-biological interactions.
[20] H. Grossniklaus,et al. Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses , 2000, Cancer Immunology, Immunotherapy.
[21] H. Kroemer,et al. Elucidation of the mechanism enabling tumor selective prodrug monotherapy. , 1998, Cancer research.
[22] K. Ye,et al. Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cells. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[23] A. Y. Lu,et al. Role of pharmacokinetics and metabolism in drug discovery and development. , 1997, Pharmacological reviews.
[24] G. Macfarlane,et al. Collaborative JPEN‐Clinical Nutrition Scientific Publications Role of intestinal bacteria in nutrient metabolism , 1997 .
[25] H. Kroemer,et al. Enhanced uptake of doxorubicin into bronchial carcinoma: beta-glucuronidase mediates release of doxorubicin from a glucuronide prodrug (HMR 1826) at the tumor site. , 1997, Cancer research.
[26] G. Macfarlane,et al. Role of intestinal bacteria in nutrient metabolism. , 1997, JPEN. Journal of parenteral and enteral nutrition.
[27] B. Lokesh,et al. Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron , 1994, Molecular and Cellular Biochemistry.
[28] R. Teel,et al. Inhibition of liver microsomal cytochrome P450 activity and metabolism of the tobacco-specific nitrosamine NNK by capsaicin and ellagic acid. , 1993, Anticancer research.
[29] G. Mulder,et al. New developments in glucuronidation research: Report of a workshop on “Glucuronidation, its role in health and disease” , 1992, Hepatology.
[30] G. Macfarlane,et al. The control and consequences of bacterial fermentation in the human colon. , 1991, The Journal of applied bacteriology.
[31] D. Drayer,et al. Pharmacologically Active Drug Metabolites: Therapeutic and Toxic Activities, Plasma and Urine Data in Man, Accumulation in Renal Failure , 1976, Clinical pharmacokinetics.
[32] J. Glass,et al. Non‐toxic melanoma therapy by a novel tubulin‐binding agent , 2010, International journal of cancer.
[33] M. Karlsson,et al. Pharmacokinetics of oral noscapine , 2004, European Journal of Clinical Pharmacology.
[34] B. Olsson,et al. Excretion of noscapine in human breast milk , 2004, European Journal of Clinical Pharmacology.
[35] S. Wrighton,et al. An assessment of udp-glucuronosyltransferase induction using primary human hepatocytes. , 2004, Drug metabolism and disposition: the biological fate of chemicals.
[36] Y Zhang,et al. The Gut as a Barrier to Drug Absorption , 2001, Clinical pharmacokinetics.