Impact of Community Treatment With Ivermectin for the Control of Scabies on the Prevalence of Antibodies to Strongyloides stercoralis in Children

Abstract The prevalence of antibodies to Strongyloides stercoralis was measured in 0–12-year-olds using a bead-based immunoassay before and after ivermectin mass drug administration (MDA) for scabies in the Solomon Islands. Seroprevalence was 9.3% before and 5.1% after MDA (P = .019), demonstrating collateral benefits of ivermectin MDA in this setting.

[1]  P. Chiodini,et al.  Multiple-dose versus single-dose ivermectin for Strongyloides stercoralis infection (Strong Treat 1 to 4): a multicentre, open-label, phase 3, randomised controlled superiority trial. , 2019, The Lancet. Infectious diseases.

[2]  J. Kaldor,et al.  Efficacy of mass drug administration with ivermectin for control of scabies and impetigo, with coadministration of azithromycin: a single-arm community intervention trial , 2019, The Lancet. Infectious diseases.

[3]  M. Redman-MacLaren,et al.  Randomized Trial of Community Treatment With Azithromycin and Ivermectin Mass Drug Administration for Control of Scabies and Impetigo , 2019 .

[4]  T. Nutman,et al.  Impact of Enhanced Health Interventions for United States–Bound Refugees: Evaluating Best Practices in Migration Health , 2017, The American journal of tropical medicine and hygiene.

[5]  J. Keiser,et al.  Efficacy of Moxidectin Versus Ivermectin Against Strongyloides stercoralis Infections: A Randomized, Controlled Noninferiority Trial , 2017, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[6]  J. McCarthy,et al.  Strongyloides seroprevalence before and after an ivermectin mass drug administration in a remote Australian Aboriginal community , 2017, PLoS neglected tropical diseases.

[7]  J. Sutra,et al.  Preclinical Study of Single-Dose Moxidectin, a New Oral Treatment for Scabies: Efficacy, Safety, and Pharmacokinetics Compared to Two-Dose Ivermectin in a Porcine Model , 2016, PLoS neglected tropical diseases.

[8]  Z. Bisoffi,et al.  Mass Administration of Ivermectin for the Elimination of Onchocerciasis Significantly Reduced and Maintained Low the Prevalence of Strongyloides stercoralis in Esmeraldas, Ecuador , 2015, PLoS neglected tropical diseases.

[9]  L. Coffeng,et al.  African Program for Onchocerciasis Control 1995–2010: Impact of Annual Ivermectin Mass Treatment on Off-Target Infectious Diseases , 2015, PLoS neglected tropical diseases.

[10]  D. MacLaren,et al.  Prevalence of soil-transmitted helminths in remote villages in East Kwaio, Solomon Islands. , 2015, Western Pacific surveillance and response journal : WPSAR.

[11]  T. Nutman,et al.  Accuracy of Five Serologic Tests for the Follow up of Strongyloides stercoralis Infection , 2015, PLoS neglected tropical diseases.

[12]  J. Andersen,et al.  Characterization of a recombinant immunodiagnostic antigen (NIE) from Strongyloides stercoralis L3-stage larvae. , 2002, Molecular and biochemical parasitology.

[13]  D. Grove.  Human strongyloidiasis. , 1996, Advances in parasitology.