Enhancement of ozone-induced lung injury by exercise.

Rats were exposed for up to 3.75 h to 0.20-0.80 ppm O3 under conditions of rest and treadmill exercise up to 30 m/min, 20% grade, to assess the importance of exposure duration, O3 concentration, and exercise on lung tissue injury. Focal lung parenchymal lesions increased in abundance and severity in response to the three variables; however, exercise was the most important. Lesion response to exercise was greater than that predicted by a simple proportion to estimated effective dose of O3. The results emphasize the importance of including exercise in assessment of possible adverse health effects of exposure to airborne pollutants.

[1]  R. Phalen,et al.  A rodent treadmill for inhalation toxicological studies and respirometry. , 1985, Journal of applied physiology.

[2]  W. C. Adams,et al.  Ozone and high ventilation effects on pulmonary function and endurance performance. , 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

[3]  D M Hyde,et al.  Synergistic effects on rat lungs of mixtures of oxidant air pollutants (ozone or nitrogen dioxide) and respirable aerosols. , 1983, The American review of respiratory disease.

[4]  D. House,et al.  Pulmonary effects of ozone exposure during exercise: dose-response characteristics. , 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

[5]  R. Phalen,et al.  An airway perfusion apparatus for whole lung fixation. , 1982, Laboratory animal science.

[6]  J. Little,et al.  Recovery from ozone-induced injury in the lungs of the Syrian golden hamster. , 1982, Experimental and molecular pathology.

[7]  W. C. Adams,et al.  Detection of ozone toxicity during continuous exercise via the effective dose concept. , 1981, Journal of applied physiology: respiratory, environmental and exercise physiology.

[8]  C. Plopper,et al.  Pulmonary alterations in rats exposed to 0.2 and 0.1 ppm ozone: a correlated morphological and biochemical study. , 1979, Archives of environmental health.

[9]  R. J. Stephens,et al.  Cytologic responses of postnatal rat lungs to O3 or NO2 exposure. , 1978, The American journal of pathology.

[10]  K. Isomura,et al.  Effects of exercise on mice exposed to ozone. , 1978, Archives of environmental health.

[11]  B. Drinkwater,et al.  Influence of exercise and heat stress on pulmonary function during ozone exposure. , 1977, Journal of applied physiology: respiratory, environmental and exercise physiology.

[12]  W. C. Adams,et al.  Effects of O3 inhalation during exercise on pulmonary function and blood biochemistry. , 1977, Journal of applied physiology: respiratory, environmental and exercise physiology.

[13]  R. Shephard,et al.  Pulmonary function changes in ozone-interaction of concentration and ventilation. , 1976, Journal of applied physiology.

[14]  W S Tyler,et al.  Pulmonary responses of rats to ambient levels of ozone: effects of 7-day intermittent or continuous exposure. , 1976, Laboratory investigation; a journal of technical methods and pathology.

[15]  R. Shephard,et al.  Exercise responses following ozone exposure. , 1975, Journal of applied physiology.

[16]  R. Frank,et al.  Morphologic and ultrastructural changes in the lungs of animals during acute exposure to ozone. , 1974, Chest.

[17]  R. J. Stephens,et al.  A comprehensive ultrastructural study of pulmonary injury and repair in the rat resulting from exposures to less than one PPM ozone. , 1974, Chest.

[18]  R. J. Stephens,et al.  Alveolar type 1 cell response to exposure to 0.5 PPM O3 for short periods. , 1974, Experimental and molecular pathology.

[19]  R. Frank,et al.  Respiratory uptake of ozone in dogs. , 1972, Archives of environmental health.

[20]  P. G. Wright,et al.  Studies of ozone toxicity. I. Potentiating effects of exercise and tolerance development. , 1956, A.M.A. archives of industrial health.

[21]  J. Crapo,et al.  Alterations in lung structure caused by inhalation of oxidants. , 1984, Journal of toxicology and environmental health.

[22]  B J Whipp,et al.  Respiratory physiology of exercise: metabolism, gas exchange, and ventilatory control. , 1981, International review of physiology.

[23]  S. Horvath,et al.  THE INFLUENCE OF EXERCISE ON THE PULMONARY FUNCTION CHANGES DUE TO EXPOSURE TO LOW CONCENTRATIONS OF OZONE , 1978 .

[24]  L. Dreifus,et al.  Complete heart block occurring during cardiac catheterization in patients with preexisting bundle branch block. , 1974, Chest.

[25]  R. J. Stephens,et al.  Early response of lung to low levels of ozone. , 1974, The American journal of pathology.

[26]  R. J. Stephens,et al.  Cytologic changes in dogs lungs induced by chronic exposure to ozone. , 1973, The American journal of pathology.

[27]  D. Bates,et al.  Pulmonary function in man after short-term exposure to ozone. , 1973, Archives of Environmental Health An International Journal.

[28]  D. Bates,et al.  Short-term effects of ozone on the lung. , 1972, Journal of applied physiology.

[29]  W. Dixon.  BMD : biomedical computer programs , 1967 .