Ventilatory response to hypercapnia by rebreathing in successive trials.

The ventilatory response to carbon dioxide at rest was determined repeatedly by the rebreathing method; three successive CO2 response lines, with 30-min intervals, were examined in 12 healthy male subjects. Overall mean slopes obtained at 30, 60 and 90 min were 2.95, 2.47 and 2.28 liters/min . mmHg, respectively, the difference being statistically not significant. However, the slopes of four high responders, who were subjects with higher slopes than that of the mean values obtained here, decreased significantly (p less than 0.05) at 60 min as compared with the 30 min test, but this did not occur in the other subjects. Better reproducibility in obtaining the CO2 response slopes in the high responders was observed in the first rather than the 60 or 90 min trails, suggesting incomplete recovery in the humoral agents released during the CO2 test. These results indicated that the CO2 response curve by rebreathing should be determined carefully, especially in the high responder, taking into consideration its individual variability and and interval in consecutive measurements.

[1]  J. Weil,et al.  Familial aspects of decreased hypoxic drive in endurance athletes. , 1978, Journal of applied physiology: respiratory, environmental and exercise physiology.

[2]  J. Weil,et al.  Variability of ventilatory responses to hypoxia and hypercapnia. , 1977, Journal of applied physiology: respiratory, environmental and exercise physiology.

[3]  Weil Jv,et al.  Effects of hyperthermia on hypoxic ventilatory response in normal man. , 1977 .

[4]  J. Weil,et al.  Effects of hyperthermia on hypoxic ventilatory response in normal man. , 1977, The Journal of laboratory and clinical medicine.

[5]  J. Dempsey,et al.  Workshop on assessment of respiratory control in humans. I. Methods of measurement of ventilatory responses to hypoxia and hypercapnia. , 1977, The American review of respiratory disease.

[6]  G. Irsigler.  Carbon dioxide response lines in young adults: the limits of the normal response. , 1976, The American review of respiratory disease.

[7]  J. Severinghaus,et al.  Proposed standard determination of ventilatory responses to hypoxia and hypercapnia in man. , 1976, Chest.

[8]  Y. Honda,et al.  Ventilatory responses to CO2 rebreathing at rest and during exercise in untrained subjects and athletes. , 1976, The Japanese journal of physiology.

[9]  L. Pengelly,et al.  Control of tidal volume during rebreathing. , 1974, Journal of applied physiology.

[10]  J. Rigg,et al.  Effect of posture on the ventilatory response to CO2. , 1974, Journal of applied physiology.

[11]  V. Klissouras,et al.  Genetic differences in the ventilatory response to inhaled CO2. , 1974, Journal of applied physiology.

[12]  R S Kronenberg,et al.  Attenuation of the ventilatory and heart rate responses to hypoxia and hypercapnia with aging in normal men. , 1973, The Journal of clinical investigation.

[13]  J. Patrick,et al.  The influence of age, sex, body size and lung size on the control and pattern of breathing during CO2 inhalation in Caucasians , 1972 .

[14]  Y. Honda,et al.  Increased ventilatory response to CO 2 by rebreathing in consecutive daily trials. , 1972, The Japanese journal of physiology.

[15]  A. Rebuck,et al.  Patterns of ventilatory response to carbon dioxide during recovery from severe asthma. , 1971, Clinical science.

[16]  T. Natsui.  Respiratory response to hypoxia with hypocapnia or normocapnia and to CO2 in hypothermic dogs , 1969 .

[17]  Flenley Dc,et al.  Ventilatory response to oxygen and carbon dioxide in chronic respiratory failure. , 1967 .

[18]  D. Flenley,et al.  Ventilatory response to oxygen and carbon dioxide in chronic respiratory failure. , 1967, Clinical science.

[19]  S. Tenney,et al.  Ventilatory response to hypoxia and CO2 following CO2 exposure and NaHCO3 ingestion. , 1966, Journal of applied physiology.

[20]  K. Schaefer,et al.  RESPIRATORY ACCLIMATIZATION TO CARBON DIOXIDE. , 1963, Journal of applied physiology.

[21]  S. K. Hong,et al.  Lung volumes and ventilatory responses to high CO2 and low O2 in the ama , 1963, Journal of applied physiology.

[22]  R. H. Kellogg.  Acclimatization to carbon dioxide. , 1960, Anesthesiology.

[23]  Prime Fj,et al.  The respiratory response to CO2 in emphysema. , 1954 .

[24]  F. Prime,et al.  The respiratory response to CO2 in emphysema. , 1954, Clinical science.