Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence.
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[1] G. Enikolopov,et al. Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis , 2019, Cell metabolism.
[2] Laura C. Greaves,et al. Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence , 2019, The EMBO journal.
[3] S. Manalis,et al. Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence , 2019, Cell.
[4] J. Parker,et al. Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence , 2019, Proceedings of the National Academy of Sciences.
[5] S. Kritchevsky,et al. Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study , 2019, EBioMedicine.
[6] J. Popp,et al. Raman and infrared spectroscopy reveal that proliferating and quiescent human fibroblast cells age by biochemically similar but not identical processes , 2018, PloS one.
[7] V. Korolchuk,et al. Rapamycin improves healthspan but not inflammaging in nfκb1 −/− mice , 2018, Aging cell.
[8] G. Nelson,et al. The bystander effect contributes to the accumulation of senescent cells in vivo , 2018, Aging cell.
[9] V. Gladyshev,et al. Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells , 2018, Aging cell.
[10] N. Musi,et al. Tau protein aggregation is associated with cellular senescence in the brain , 2018, Aging cell.
[11] D. Baker,et al. Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline , 2018, Nature.
[12] Frédérick A. Mallette,et al. Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest. , 2018, Trends in cell biology.
[13] R. Faragher,et al. Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing , 2018, Biogerontology.
[14] Bin Zhou,et al. Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth , 2018, Cell Research.
[15] D. Allison,et al. Senolytics Improve Physical Function and Increase Lifespan in Old Age , 2018, Nature Medicine.
[16] J. Speakman,et al. The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon , 2018, Aging cell.
[17] C. O’Flanagan,et al. Obesity and Cancer Metabolism: A Perspective on Interacting Tumor–Intrinsic and Extrinsic Factors , 2017, Front. Oncol..
[18] S. Gollnick,et al. p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli , 2017, Aging.
[19] P. Kaldis,et al. Cell size control – a mechanism for maintaining fitness and function , 2017, BioEssays : news and reviews in molecular, cellular and developmental biology.
[20] N. LeBrasseur,et al. Targeting cellular senescence prevents age-related bone loss in mice , 2017, Nature Medicine.
[21] Caroline L. Wilson,et al. Cellular senescence drives age-dependent hepatic steatosis , 2017, Nature Communications.
[22] C. Rallis,et al. The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth , 2017, Front. Cell Dev. Biol..
[23] Teemu P. Miettinen,et al. Mitochondrial Function and Cell Size: An Allometric Relationship. , 2017, Trends in cell biology.
[24] Yossi Ovadya,et al. Quantitative identification of senescent cells in aging and disease , 2017, Aging cell.
[25] J. Elisseeff,et al. Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment , 2017, Nature Medicine.
[26] M. Pellegrini,et al. Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence , 2018, Stem cell reports.
[27] Wiggert A. van Cappellen,et al. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging , 2017, Cell.
[28] Pang Wei Koh,et al. Localized hepatic lobular regeneration by central-vein–associated lineage-restricted progenitors , 2017, Proceedings of the National Academy of Sciences.
[29] J. Cooke,et al. Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS‐modulating technologies for augmentation of the healing process , 2017, International wound journal.
[30] T. Wadden,et al. Mechanisms, Pathophysiology, and Management of Obesity , 2017, The New England journal of medicine.
[31] Jaewhan Song,et al. Dynamics of ARF regulation that control senescence and cancer , 2016, BMB reports.
[32] Teemu P. Miettinen,et al. Cellular Allometry of Mitochondrial Functionality Establishes the Optimal Cell Size , 2016, Developmental cell.
[33] N. LeBrasseur,et al. Identification of Senescent Cells in the Bone Microenvironment , 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[34] C. Conover,et al. Senescent intimal foam cells are deleterious at all stages of atherosclerosis , 2016, Science.
[35] Frédérick A. Mallette,et al. Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy , 2016, Science Translational Medicine.
[36] Elizabeth A. Jensen,et al. Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice , 2016, Nutrition and healthy aging.
[37] Kenichi Yoshida,et al. IGF-I induces senescence of hepatic stellate cells and limits fibrosis in a p53-dependent manner , 2016, Scientific Reports.
[38] A. Gudkov,et al. Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells , 2016, Aging.
[39] G. Saade,et al. Differential senescence in feto-maternal tissues during mouse pregnancy. , 2016, Placenta.
[40] N. Barzilai,et al. The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research. , 2016, Cell metabolism.
[41] Ó. Gutiérrez-Gutiérrez,et al. Postnatal telomere dysfunction induces cardiomyocyte cell-cycle arrest through p21 activation , 2016, The Journal of cell biology.
[42] M. Narita,et al. Old cells, new tricks: chromatin structure in senescence , 2016, Mammalian Genome.
[43] A. Klochendler,et al. p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion , 2016, Nature Medicine.
[44] M. Jensen,et al. Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue , 2016, Diabetes.
[45] Laura C. Greaves,et al. Mitochondria are required for pro‐ageing features of the senescent phenotype , 2016, The EMBO journal.
[46] A. Pezeshki,et al. Naturally occurring p16Ink4a-positive cells shorten healthy lifespan , 2016, Nature.
[47] M. Velarde,et al. Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype. , 2016, Cell metabolism.
[48] G. Stamp,et al. Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis , 2016, eLife.
[49] M. Jensen,et al. JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age , 2015, Proceedings of the National Academy of Sciences.
[50] M. Belvisi,et al. DNA damage response at telomeres contributes to lung aging and chronic obstructive pulmonary disease , 2015, American journal of physiology. Lung cellular and molecular physiology.
[51] G. Saade,et al. Chorioamniotic membrane senescence: a signal for parturition? , 2015, American journal of obstetrics and gynecology.
[52] L. Zender,et al. mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype , 2015, Nature Cell Biology.
[53] P. Nelson,et al. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation , 2015, Nature Cell Biology.
[54] R. Nusse,et al. Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver , 2015, Nature.
[55] M. Kirschner,et al. On being the right (cell) size , 2015, Science.
[56] Maximina H. Yun,et al. Recurrent turnover of senescent cells during regeneration of a complex structure , 2015, eLife.
[57] J. Campisi,et al. Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing , 2015, Nature Communications.
[58] L. Partridge,et al. Promoting Health and Longevity through Diet: From Model Organisms to Humans , 2015, Cell.
[59] C. Abbadie,et al. The unfolded protein response and cellular senescence. A review in the theme: cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. , 2015, American journal of physiology. Cell physiology.
[60] S. Levison,et al. Insulin and IGF receptor signalling in neural-stem-cell homeostasis , 2015, Nature Reviews Endocrinology.
[61] J. Hoeijmakers,et al. An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. , 2014, Developmental cell.
[62] S. Diekmann,et al. Long-Term Quiescent Fibroblast Cells Transit into Senescence , 2014, PloS one.
[63] M. Blagosklonny,et al. Gerosuppression in confluent cells , 2014, Aging.
[64] S. J. Griffiths,et al. p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8⁺ T cells. , 2014, The Journal of clinical investigation.
[65] Glyn Nelson,et al. Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions , 2014, PLoS Comput. Biol..
[66] A. Oberg,et al. Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice , 2014, Aging.
[67] Yong Xia,et al. Reversal of hepatocyte senescence after continuous in vivo cell proliferation , 2014, Hepatology.
[68] Manuel Serrano,et al. Cellular senescence: from physiology to pathology , 2014, Nature Reviews Molecular Cell Biology.
[69] M. Blagosklonny,et al. Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program , 2014, Proceedings of the National Academy of Sciences.
[70] J. Deursen. The role of senescent cells in ageing , 2014, Nature.
[71] Paul M. Rindler,et al. The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response , 2014, Cell.
[72] Nam‐Gyun Kim,et al. The Hippo-YAP signaling pathway and contact inhibition of growth , 2014, Journal of Cell Science.
[73] E. Ballestar,et al. Geriatric muscle stem cells switch reversible quiescence into senescence , 2014, Nature.
[74] K. Nakayama,et al. CDK inhibitors, p21(Cip1) and p27(Kip1), participate in cell cycle exit of mammalian cardiomyocytes. , 2014, Biochemical and biophysical research communications.
[75] J. Lawrence,et al. Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence , 2013, The Journal of cell biology.
[76] Peter D. Adams,et al. Senescent cells harbour features of the cancer epigenome , 2013, Nature Cell Biology.
[77] J. Sharpe,et al. Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning , 2013, Cell.
[78] A. Rodríguez-Baeza,et al. Programmed Cell Senescence during Mammalian Embryonic Development , 2013, Cell.
[79] G. Ferbeyre,et al. Metformin inhibits the senescence‐associated secretory phenotype by interfering with IKK/NF‐κB activation , 2013, Aging cell.
[80] J. de Magalhães. How ageing processes influence cancer , 2013, Nature Reviews Cancer.
[81] Andreas Krieg,et al. Impact of the 3D Microenvironment on Phenotype, Gene Expression, and EGFR Inhibition of Colorectal Cancer Cell Lines , 2013, PloS one.
[82] J. Campisi. Aging, cellular senescence, and cancer. , 2013, Annual review of physiology.
[83] V. Korolchuk,et al. Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response , 2012, Aging cell.
[84] Richard A.F. Clark,et al. The Molecular and Cellular Biology of Wound Repair , 2012, Springer US.
[85] Muhammad Zaman,et al. Alteration of Cellular Behavior and Response to PI3K Pathway Inhibition by Culture in 3D Collagen Gels , 2012, PloS one.
[86] Sungmin Son,et al. Direct observation of mammalian cell growth and size regulation , 2012, Nature Methods.
[87] Martin Wasser,et al. Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration , 2012, Proceedings of the National Academy of Sciences.
[88] Clara Correia-Melo,et al. Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence , 2012, Nature Communications.
[89] N. LeBrasseur,et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders , 2011, Nature.
[90] N. Schaum,et al. p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes , 2011, The Journal of cell biology.
[91] M. Berciano,et al. Effect of ionizing radiation in sensory ganglion neurons: organization and dynamics of nuclear compartments of DNA damage/repair and their relationship with transcription and cell cycle , 2011, Acta Neuropathologica.
[92] J. Campisi,et al. p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype , 2011, The EMBO journal.
[93] J. Campisi,et al. Four faces of cellular senescence , 2011, The Journal of cell biology.
[94] M. Blagosklonny,et al. DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence , 2010, Aging.
[95] M. Jensen,et al. Fat tissue, aging, and cellular senescence , 2010, Aging cell.
[96] R. Ian Freshney,et al. Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications , 2010 .
[97] R. Godschalk,et al. Adult-onset, short-term dietary restriction reduces cell senescence in mice , 2010, Aging.
[98] M. Narita. Quality and quantity control of proteins in senescence , 2010, Aging.
[99] Anil Wipat,et al. Feedback between p21 and reactive oxygen production is necessary for cell senescence , 2010, Molecular systems biology.
[100] Masayuki Orimo,et al. A crucial role for adipose tissue p53 in the regulation of insulin resistance , 2009, Nature Medicine.
[101] Marco Pahor,et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice , 2009, Nature.
[102] A. Asthagiri,et al. Tunable interplay between epidermal growth factor and cell–cell contact governs the spatial dynamics of epithelial growth , 2009, Proceedings of the National Academy of Sciences.
[103] G. Ferbeyre,et al. Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence , 2009, Molecular and Cellular Biology.
[104] G. Nelson,et al. DNA damage response and cellular senescence in tissues of aging mice , 2009, Aging cell.
[105] J. Campisi,et al. Persistent DNA damage signaling triggers senescence-associated inflammatory cytokine secretion , 2009, Nature Cell Biology.
[106] Judith Campisi,et al. Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor , 2008, PLoS biology.
[107] A. Bartke. Growth hormone and aging: A challenging controversy , 2008, Clinical interventions in aging.
[108] D. Kristan. Calorie restriction and susceptibility to intact pathogens , 2008, AGE.
[109] Lewis A. Chodosh,et al. Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis , 2007, Nature Cell Biology.
[110] James H Brown,et al. Scaling of number, size, and metabolic rate of cells with body size in mammals , 2007, Proceedings of the National Academy of Sciences.
[111] N. Sharpless,et al. The Regulation of INK4/ARF in Cancer and Aging , 2006, Cell.
[112] D. DiMaio,et al. Senescence‐associated β‐galactosidase is lysosomal β‐galactosidase , 2006 .
[113] J. Sedivy,et al. Cellular Senescence in Aging Primates , 2006, Science.
[114] F. Oesch,et al. p38α MAPK is required for contact inhibition , 2005, Oncogene.
[115] Morihiro Matsuda,et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. , 2004, The Journal of clinical investigation.
[116] H. Beug,et al. Evidence for a size-sensing mechanism in animal cells , 2004, Nature Cell Biology.
[117] W. Hahn,et al. Mitogen Stimulation Cooperates with Telomere Shortening To Activate DNA Damage Responses and Senescence Signaling , 2004, Molecular and Cellular Biology.
[118] Sam W. Lee,et al. Influence of Induced Reactive Oxygen Species in p53-Mediated Cell Fate Decisions , 2003, Molecular and Cellular Biology.
[119] C. Chi,et al. Increase in mitochondrial mass in human fibroblasts under oxidative stress and during replicative cell senescence. , 2002, Journal of biomedical science.
[120] Li Fang,et al. Inhibition of p21‐mediated ROS accumulation can rescue p21‐induced senescence , 2002, The EMBO journal.
[121] I. Conlon,et al. Extracellular control of cell size , 2001, Nature Cell Biology.
[122] D. Kurz,et al. Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells. , 2000, Journal of cell science.
[123] R. G. Allen,et al. Is beta-galactosidase staining a marker of senescence in vitro and in vivo? , 2000, Experimental cell research.
[124] F. Oesch,et al. p16INK4 mediates contact-inhibition of growth , 1999, Oncogene.
[125] G. Saretzki,et al. Accelerated telomere shortening in fibroblasts after extended periods of confluency. , 1998, Free radical biology & medicine.
[126] M. Reed,et al. Enhanced cell proliferation and biosynthesis mediate improved wound repair in refed, caloric-restricted mice , 1996, Mechanisms of Ageing and Development.
[127] B. Ames,et al. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[128] A. Zetterberg,et al. QUANTITATIVE CYTOCHEMICAL STUDIES ON INTERPHASE GROWTH. I. DETERMINATION OF DNA, RNA AND MASS CONTENT OF AGE DETERMINED MOUSE FIBROBLASTS IN VITRO AND OF INTERCELLULAR VARIATION IN GENERATION TIME. , 1965, Experimental cell research.
[129] L. Hayflick. THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS. , 1965, Experimental cell research.
[130] T. von Zglinicki,et al. The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State? , 2017, Journal of Alzheimer's disease : JAD.
[131] D. Kurz,et al. Senescence-associated β-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells , 2000 .
[132] James M. Roberts,et al. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. , 1994, Genes & development.