Geriatric Nutritional Risk Index: a new index for evaluating at-risk elderly medical patients.

BACKGROUND Patients at risk of malnutrition and related morbidity and mortality can be identified with the Nutritional Risk Index (NRI). However, this index remains limited for elderly patients because of difficulties in establishing their normal weight. OBJECTIVE Therefore, we replaced the usual weight in this formula by ideal weight according to the Lorentz formula (WLo), creating a new index called the Geriatric Nutritional Risk Index (GNRI). DESIGN First, a prospective study enrolled 181 hospitalized elderly patients. Nutritional status [albumin, prealbumin, and body mass index (BMI)] and GNRI were assessed. GNRI correlated with a severity score taking into account complications (bedsores or infections) and 6-mo mortality. Second, the GNRI was measured prospectively in 2474 patients admitted to a geriatric rehabilitation care unit over a 3-y period. RESULTS The severity score correlated with albumin and GNRI but not with BMI or weight:WLo. Risk of mortality (odds ratio) and risk of complications were, respectively, 29 (95% CI: 5.2, 161.4) and 4.4 (95% CI: 1.3, 14.9) for major nutrition-related risk (GNRI: <82), 6.6 (95% CI: 1.3, 33.0), 4.9 (95% CI: 1.9, 12.5) for moderate nutrition-related risk (GNRI: 82 to <92), and 5.6 (95% CI: 1.2, 26.6) and 3.3 (95% CI: 1.4, 8.0) for a low nutrition-related risk (GNRI: 92 to < or =98). Accordingly, 12.2%, 31.4%, 29.4%, and 27.0% of the 2474 patients had major, moderate, low, and no nutrition-related risk, respectively. CONCLUSION GNRI is a simple and accurate tool for predicting the risk of morbidity and mortality in hospitalized elderly patients and should be recorded systematically on admission.

[1]  M. Katan,et al.  Specificity of indexes of malnutrition when applied to apparently healthy people: the effect of age. , 1997, American Journal of Clinical Nutrition.

[2]  P. Roberson,et al.  Undernutrition and risk of mortality in elderly patients within 1 year of hospital discharge. , 2002, The journals of gerontology. Series A, Biological sciences and medical sciences.

[3]  F. Landi,et al.  Changes in nutritional status during the hospital stay: A predictor of long-term survival , 1998, Aging.

[4]  J P Doweiko,et al.  The role of albumin in human physiology and pathophysiology, Part III: Albumin and disease states. , 1991, JPEN. Journal of parenteral and enteral nutrition.

[5]  J. Hafkenscheid,et al.  Study of the molecular mechanism of decreased liver synthesis of albumin in inflammation. , 1987, The Journal of clinical investigation.

[6]  S. Volpato,et al.  Body Mass Index, Body Cell Mass, and 4‐Year All‐Cause Mortality Risk in Older Nursing Home Residents , 2004, Journal of the American Geriatrics Society.

[7]  M. Elia,et al.  ESPEN guidelines for nutrition screening 2002. , 2003, Clinical nutrition.

[8]  E. Alix,et al.  Outils et procédures de dépistage de la dénutrition et de son risque en milieu hospitalier , 2003 .

[9]  W. Williford,et al.  A randomized clinical trial of total parenteral nutrition in malnourished surgical patients: the rationale and impact of previous clinical trials and pilot study on protocol design. , 1988, The American journal of clinical nutrition.

[10]  François Vincent,et al.  Body mass index , 2004, Intensive Care Medicine.

[11]  P Bjurulf,et al.  Effect of dietary supplement on nutritional status and clinical outcome in 501 geriatric patients--a randomised study. , 1990, Clinical nutrition.

[12]  P. Wilson,et al.  Monocyte cytokine production in an elderly population: effect of age and inflammation. , 1998, The journals of gerontology. Series A, Biological sciences and medical sciences.

[13]  E. Cook,et al.  Body mass index and mortality among nonsmoking older persons. The Framingham Heart Study. , 1988, JAMA.

[14]  J. Doweiko,et al.  Reviews: Role of Albumin in Human Physiology and Pathophysiology , 1991 .

[15]  J. Timsit,et al.  Body mass index. An additional prognostic factor in ICU patients. , 2004, Intensive care medicine.

[16]  J. Sorkin,et al.  Serum albumin level and physical disability as predictors of mortality in older persons. , 1994, JAMA.

[17]  Emmett Keeler,et al.  Development of a Method to Identify Seniors at High Risk for High Hospital Utilization , 2002, Medical care.

[18]  S. Smye,et al.  Extracellular fluid volume determined by bioelectric impedance and serum albumin in CAPD patients. , 1998, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[19]  R. Kuczmarski,et al.  Effects of age on validity of self-reported height, weight, and body mass index: findings from the Third National Health and Nutrition Examination Survey, 1988-1994. , 2001, Journal of the American Dietetic Association.

[20]  P. Ritz Validity of measuring knee-height as an estimate of height in diseased French elderly persons. , 2004, The journal of nutrition, health & aging.

[21]  J. Vaqué,et al.  Malnutrición caloricoproteica y linfocitopenia como predictores de infección hospitalaria en ancianos , 2001 .

[22]  A. Roche,et al.  Estimating Stature from Knee Height for Persons 60 to 90 Years of Age , 1985, Journal of the American Geriatrics Society.

[23]  J. Eisenberg,et al.  Study protocol: a randomized clinical trial of total parenteral nutrition in malnourished surgical patients. , 1988, The American journal of clinical nutrition.

[24]  J. Doweiko,et al.  Reviews: The Role of Albumin in Human Physiology and Pathophysiology, Part III: Albumin and Disease States , 1991 .

[25]  R. D'Agostino,et al.  Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study. , 2003, The American journal of medicine.

[26]  F. Herrmann,et al.  Prognostic role of serum albumin and prealbumin levels in elderly patients at admission to a geriatric hospital. , 1991, Archives of gerontology and geriatrics.

[27]  P. Ballmer Causes and mechanisms of hypoalbuminaemia. , 2001, Clinical nutrition.

[28]  P. Roberson,et al.  Protein-energy undernutrition and life-threatening complications among the hospitalized elderly , 2002, Journal of General Internal Medicine.

[29]  A. M. R. Pablo,et al.  Assessment of nutritional status on hospital admission: nutritional scores , 2003, European Journal of Clinical Nutrition.

[30]  J. Nordenström,et al.  Nutritional Status Using Mini Nutritional Assessment and Subjective Global Assessment Predict Mortality in Geriatric Patients , 2002, Journal of the American Geriatrics Society.

[31]  Y. Bacq,et al.  Protein‐Energy Malnutrition in Elderly Medical Patients , 1992, Journal of the American Geriatrics Society.

[32]  E. Rothenberg,et al.  Body mass index, weight change and mortality in the elderly. A 15 y longitudinal population study of 70 y olds , 2001, European Journal of Clinical Nutrition.

[33]  L. Robbins Evaluation of weight loss in the elderly. , 1989, Geriatrics.

[34]  A. LaCroix,et al.  Involuntary Weight Loss in Older Outpatients: Incidence and Clinical Significance , 1995, Journal of the American Geriatrics Society.